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pro vyhledávání: '"Heather J. Johnston"'
Autor:
David Georgiev, Bartholomeus W. H. Saes, Heather J. Johnston, Sarah K. Boys, Alan Healy, Alison N. Hulme
Publikováno v:
Molecules, Vol 21, Iss 1, p 88 (2016)
The mono ortho-bromination of phenolic building blocks by NBS has been achieved in short reaction times (15–20 min) using ACS-grade methanol as a solvent. The reactions can be conducted on phenol, naphthol and biphenol substrates, giving yields of
Externí odkaz:
https://doaj.org/article/75fbe2624b844058a5a5729029db62e9
Autor:
John David Parkin, Elisavet Makou, Richard G. Bailey, Georg Hähner, Heather J. Johnston, Paul N. Barlow, Alison N. Hulme
Publikováno v:
The Journal of Biological Chemistry
Makou, E, Bailey, R G, Johnston, H, Parkin, J D, Hulme, A N, Hähner, G & Barlow, P N 2019, ' Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade ', Journal of Biological Chemistry, vol. 294, no. 52, pp. 20148-20163 . https://doi.org/10.1074/jbc.RA119.010913
Makou, E, Bailey, R G, Johnston, H, Parkin, J D, Hulme, A N, Hähner, G & Barlow, P N 2019, ' Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade ', Journal of Biological Chemistry, vol. 294, no. 52, pp. 20148-20163 . https://doi.org/10.1074/jbc.RA119.010913
This work was supported by Leverhulme Trust Grant RPG-2015-109. Activation and suppression of the complement system compete on every serum-exposed surface, host or foreign. Potentially harmful outcomes of this competition depend on surface molecules
Autor:
Alison N. Hulme, Heather J. Johnston
Publikováno v:
Synlett. 24:591-594
A facile, scalable synthesis of α-methyl cysteine with three alternate thiol protecting groups (trityl, allyl and tert-butyl) is described. The thiol-protected amino acids are obtained in six steps from l -cysteine ethyl ester and are ideally suited
Publikováno v:
ChemInform. 46
A range of 4-substituted prolines can be rapidly synthesized from a protected glycine Schiff base in only four steps and in 27-55% overall yield. Phase transfer catalysis allows direct access to both enantiomeric series, and the relative stereochemis
Publikováno v:
Johnston, H J, Mcwhinnie, F S, Landi, F & Hulme, A N 2014, ' Flexible, Phase-Transfer Catalyzed Approaches to 4-Substituted Prolines ', Organic letters, vol. 16, no. 18, pp. 4778–4781 . https://doi.org/10.1021/ol502239g
A range of 4-substituted prolines can be rapidly synthesized from a protected glycine Schiff base in only four steps and in 27–55% overall yield. Phase transfer catalysis allows direct access to both enantiomeric series, and the relative stereochem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0217ec3f61aed46f42eb0468ec264412
https://hdl.handle.net/20.500.11820/713813f9-1eeb-491c-914e-10c5cbd2213b
https://hdl.handle.net/20.500.11820/713813f9-1eeb-491c-914e-10c5cbd2213b
Publikováno v:
ChemBioChem. 17:1580-1580