Abstract LB202: Biphosphorylated Src at Y416/527 is active in triple-negative breast cancer cell lines and a subset of patient samples

Autor: Luke J. Nelson, Nguyen B. Dinh, Scott Heinemann, Olga V. Razorenova, Heather J. Wright, Kevin Nguyen

Publikováno v: Cancer Research. 81:LB202-LB202

Targeted therapeutics are needed for triple-negative breast cancer (TNBC). In this study, we investigated the activation of Src family of cytoplasmic tyrosine kinases (SFKs) and two SFK substrates: CUB-domain containing protein 1 (CDCP1) and protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6268f4571d8e8035e1e578471b9bb33
https://doi.org/10.1158/1538-7445.am2021-lb202

Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering

Autor: Urmi Sheth, Giovanni A. Botten, Christopher C.W. Hughes, Medha M. Pathak, Heather J. Wright, Elliot L. Botvinick, Lisa A. Flanagan, Daniel S. Yanni, Janahan Arulmoli, Richard Que, Duc T. T. Phan, Olga V. Razorenova, Mark Keating, Thomas I. Zarembinski

Publikováno v: Acta biomaterialia
Arulmoli, J; Wright, HJ; Phan, DTT; Sheth, U; Que, RA; Botten, GA; et al.(2016). Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering. ACTA BIOMATERIALIA, 43, 122-138. doi: 10.1016/j.actbio.2016.07.043. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/44r975rg

Human neural stem/progenitor cells (hNSPCs) are good candidates for treating central nervous system (CNS) trauma since they secrete beneficial trophic factors and differentiate into mature CNS cells; however, many cells die after transplantation. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b992784679cec167119c8cf54a3df719
http://europepmc.org/articles/PMC5386322

CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation

Autor: Heather J. Wright, Jue Hou, Binzhi Xu, Olga V. Razorenova, Marvin Cortez, Eric O. Potma, Bruce J. Tromberg

Publikováno v: Wright, HJ; Hou, J; Xu, B; Cortez, M; Potma, EO; Tromberg, BJ; et al.(2017). CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(32), E6556-E6565. doi: 10.1073/pnas.1703791114. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2j55q5tw
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 32

Triple-negative breast cancer (TNBC) is notoriously aggressive with high metastatic potential, which has recently been linked to high rates of fatty acid oxidation (FAO). Here we report the mechanism of lipid metabolism dysregulation in TNBC through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0d3445bab92108dc3d73c7a774c2c0
https://pubmed.ncbi.nlm.nih.gov/28739932

Two-Photon Excited Fluorescence Imaging and Oxygen Flux Analysis of Optical Redox Ratios in Breast Cancer Cells

Autor: Heather J. Wright, Jue Hou, Eric O. Potma, Olga V. Razorenova, Bruce J. Tromberg, Richard D. H. Tran, Nichole Chan

Publikováno v: Biomedical Optics 2016.

Dynamic, label-free imaging of cell metabolism using two photon excited fluorescence (TPEF) microscopy typically employs dual wavelength excitation of NADH and FAD+. The intrinsic fluorescence from these two cofactors can be used to calculate an opti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd329ae0068825d26ad1f6598585843e
https://doi.org/10.1364/cancer.2016.cth2a.2

MicroRNAs downregulate Bag of marbles to ensure proper terminal differentiation in the Drosophila male germline

Autor: Caitlin H. Choi, Xin Chen, Patrick M. Stoiber, Karen E. McMurdie, Qiang Gan, Cindy Lim, Suk Ho Eun, Heather J. Wright

In many adult stem cell lineages, the continuous production of functional differentiated cells depends on the maintenance of progenitor cells in an undifferentiated and proliferative state, as well as the subsequent commitment to proper terminal diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f900b084612c1a25653511c2e7be8c9
https://europepmc.org/articles/PMC3513990/