Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Heather J Spence"'
Autor:
Savvas Nikolaou, Amelie Juin, Jamie A Whitelaw, Nikki R Paul, Loic Fort, Colin Nixon, Heather J Spence, Sheila Bryson, Laura M Machesky
Publikováno v:
eLife, Vol 13 (2024)
Pancreatic ductal adenocarcinoma carries a dismal prognosis, with high rates of metastasis and few treatment options. Hyperactivation of KRAS in almost all tumours drives RAC1 activation, conferring enhanced migratory and proliferative capacity as we
Externí odkaz:
https://doaj.org/article/3ef6ce7cbce2496185636f37f848fb70
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e31141 (2012)
Cell-cell junctions are an integral part of epithelia and are often disrupted in cancer cells during epithelial-to-mesenchymal transition (EMT), which is a main driver of metastatic spread. We show here that Metastasis suppressor-1 (Mtss1; Missing in
Externí odkaz:
https://doaj.org/article/a5e57de7038d49d480ef17bb33be33eb
Autor:
Alessia Floerchinger, Kendelle J. Murphy, Sharissa L. Latham, Sean C. Warren, Andrew T. McCulloch, Young-Kyung Lee, Janett Stoehr, Pauline Mélénec, Cris S. Guaman, Xanthe L. Metcalf, Victoria Lee, Anaiis Zaratzian, Andrew Da Silva, Michael Tayao, Sonia Rolo, Monica Phimmachanh, Ghazal Sultani, Laura McDonald, Susan M. Mason, Nicola Ferrari, Lisa M. Ooms, Anna-Karin E. Johnsson, Heather J. Spence, Michael F. Olson, Laura M. Machesky, Owen J. Sansom, Jennifer P. Morton, Christina A. Mitchell, Michael S. Samuel, David R. Croucher, Heidi C.E. Welch, Karen Blyth, C. Elizabeth Caldon, David Herrmann, Kurt I. Anderson, Paul Timpson, Max Nobis
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109689- (2021)
Summary: Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing off-target effects. Here, using longitudinal intravital imaging of a Rac1-Förster resonance energy transfer (
Externí odkaz:
https://doaj.org/article/60a7564e516e42fe894cc587d92fc98e
Autor:
Vasileios Papalazarou, James Drew, Amelie Juin, Heather J. Spence, Jamie Whitelaw, Colin Nixon, Manuel Salmeron-Sanchez, Laura M. Machesky
Peer reviewed: True
Funder: University of Glasgow; Id: http://dx.doi.org/10.13039/501100000853
Pancreatic cancer is a deadly and highly metastatic disease, although how metastatic lesions establish is not fully understood. A key feature of
Funder: University of Glasgow; Id: http://dx.doi.org/10.13039/501100000853
Pancreatic cancer is a deadly and highly metastatic disease, although how metastatic lesions establish is not fully understood. A key feature of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e39094168a55adf4f6c2542d02dacb9
Autor:
Savvas Nikolaou, Amelie Juin, Jamie A. Whitelaw, Nikki R. Paul, Loic Fort, Colin Nixon, Heather J. Spence, Sheila Bryson, Laura M. Machesky
Pancreatic ductal adenocarcinoma carries a dismal prognosis, with high rates of metastasis and few treatment options. Hyperactivation of KRAS in almost all tumours drives RAC1 activation, conferring enhanced migratory and proliferative capacity as we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eca93f5b72c939610fce94f9f9d6ba8
https://doi.org/10.1101/2022.11.23.517689
https://doi.org/10.1101/2022.11.23.517689
Autor:
Laura M. Machesky, Sharissa L. Latham, Karen Blyth, Owen J. Sansom, Paul Timpson, Cris S. Guaman, Victoria Lee, Nicola Ferrari, Anaiis Zaratzian, Sean C. Warren, Susan M. Mason, Pauline Mélénec, Lisa M Ooms, C. Elizabeth Caldon, Andrew M. Da Silva, Andrew T. McCulloch, Michael F. Olson, Xanthe L. Metcalf, Ghazal Sultani, Monica Phimmachanh, David Herrmann, Michael Tayao, Max Nobis, Alessia Floerchinger, Janett Stoehr, Jennifer P. Morton, Anna-Karin E. Johnsson, Christina Anne Mitchell, Heather J. Spence, Kendelle J. Murphy, David R. Croucher, Sonia Rolo, Heidi C.E. Welch, Young-Kyung Lee, Michael S. Samuel, Laura McDonald, Kurt I. Anderson
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109689-(2021)
Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing off-target effects. Here, using longitudinal intravital imaging of a Rac1-Forster resonance energy transfer (FRET) bios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e60a0a238c9fea39f12263962e274fc
Autor:
Laura M. Machesky, Hans-Henning Arnold, Heather J. Spence, Vasileios Papalazarou, Klemens Rottner, Karthic Swaminathan, Ines Lahmann, Colin Nixon, Manuel Salmerón-Sánchez, Farah Jaber-Hijazi
Publikováno v:
Development (Cambridge, England)
England
article-version (VoR) Version of Record
England
article-version (VoR) Version of Record
The Arp2/3 complex is essential for the assembly of branched filamentous actin, but its role in physiology and development is surprisingly little understood. Melanoblasts deriving from the neural crest migrate along the developing embryo and traverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2daf30fbae3e38d5a622df5aa0c81fd3
https://eprints.gla.ac.uk/226709/1/226709.pdf
https://eprints.gla.ac.uk/226709/1/226709.pdf
Autor:
Loic Fort, Laura M. Machesky, Hayley T Morris, James H. Park, Francis A. Carey, Scott B. Snapper, Heather J. Spence, Rachana Patel, David F. Vincent, Owen J. Sansom
Publikováno v:
The Journal of Pathology. 245:337-348
N-WASP (WASL) is a widely expressed cytoskeletal signalling and scaffold protein also implicated in regulation of Wnt signalling and homeostatic maintenance of skin epithelial architecture. N-WASP mediates invasion of cancer cells in vitro and its de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bacab39fce82c2232274228417070650
https://doi.org/10.1002/path.5086
https://doi.org/10.1002/path.5086
Autor:
Ewan J. McGhee, Kirsty J. Martin, Laura M. Machesky, Sergio Lilla, Nikolaj Gadegaard, Gabriela Kalna, Jim C. Norman, Peter A. Thomason, Yvette W. H. Koh, Gillian M. Mackay, Matthew Neilson, Heather J. Spence, Amelie Juin, Robert H. Insall, Loic Fort, Marie F.A. Cutiongco
Publikováno v:
Cutiongco, M 2019, ' N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis ', Developmental cell . https://doi.org/10.1016/j.devcel.2019.09.018
Pancreatic ductal adenocarcinoma is one of the most invasive and metastatic cancers and has a dismal 5-year survival rate. We show that N-WASP drives pancreatic cancer metastasis, with roles in both chemotaxis and matrix remodeling. lysophosphatidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5528fa73ea330570a305078fecd9db4
https://eprints.gla.ac.uk/201664/9/201664.pdf
https://eprints.gla.ac.uk/201664/9/201664.pdf
Autor:
Loic Fort, Matthew Neilson, Peter A. Thomason, Grant S. Mastick, Luke H. Chamberlain, Kirsty J. Martin, David M. Bryant, Petra Tafelmeyer, Jennifer Greaves, Shehab Ismail, José Miguel Batista, Luke Tweedy, Heather J. Spence, Kurt I. Anderson, Sara Zanivan, Nicholas C. O. Tomkinson, Peter Brown, Sergio Lilla, Jamie Whitelaw, Laura M. Machesky, Robert H. Insall
Publikováno v:
Nature Cell Biology
Actin-based protrusions driving cell migration are reinforced through positive feedback, but it is unclear how the cell restricts the eventual size of protrusions or limits positive signals to allow them to split or retract. We have identified an evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88dd6f626bfd0606e09dca00a09867b9
https://strathprints.strath.ac.uk/65553/1/Fort_etal_NCB2018_Fam49_CYRI_interacts_with_Rac1_and_locally_suppresses_protrusions.pdf
https://strathprints.strath.ac.uk/65553/1/Fort_etal_NCB2018_Fam49_CYRI_interacts_with_Rac1_and_locally_suppresses_protrusions.pdf