Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Heather Hogg"'
Autor:
R. Ursula Kammlott, Deborah Carol Reuter, Teresa Alejandra Trejo-Martin, Leyi Gong, Christophe Michoud, Andreas Kuglstatter, Patricia Tran, David Michael Goldstein, Yun-Chou Tan, Parcharee Tivitmahaisoon, Linghao Niu, Shao-Yong Wu, Sue Jin, Paul Weller, Gary Hsieh, Karin Ann Stein, Humberto Bartolome Arzeno, James Patrick Dunn, Ada Shao, Wylie Solang Palmer, J. Heather Hogg, Johannes C. Hermann, Kung-ching Chang, Bindu Goyal, Alam Jahangir, Cheryl Janson, Tania Silva, Christine Lukacs, Paul J. Wagner, Muzaffar Alam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1486-1492
A series of amino-pyrimidines was developed based upon an initial kinase cross-screening hit from a CDK2 program. Kinase profiling and structure-based drug design guided the optimization from the initial 1,2,3-benzotriazole hit to a potent and select
Autor:
Eugenia Zhornisky, Y. David Saito, J. Heather Hogg, Dimitrios Stefanidis, Witold Woroniecki, Todd R. Elworthy, James Patrick Dunn, Grace Lam, Amy S. Zhou, Tania Silva, Klaus Klumpp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:6344-6347
The N-2 position of pyridazinone 1, a potent HIV-1 NNRTI that has limited aqueous solubility, was derivatized into a series of hydroxymethyl esters and carbonates as well as one phosphate. The derivatives served as prodrugs to effectively deliver 1 t
Autor:
Chi-Huey Wong, Ian R. Ollmann, Anders Wetterholm, Jesper Z. Haeggström, Bengt Samuelsson, Martina Andberg, J. Heather Hogg
Publikováno v:
Chemistry - A European Journal. 4:1698-1713
The synthesis of a potent competitive LTA4hydrolase inhibitor (A, Ki=1.6 nM) prompted an investigation into the biological activity of A against LTB4 biosynthesis, as well as the design, synthesis, and evaluation of a new series of inhibitors B to fu
Autor:
Cheryl Janson, Martin Weisel, Barry Goggin, Liang Weiling, Adrian J. Fretland, Robert Francis Kester, Christine Lukacs, Edmund Lee, Jennifer Lo, J. Heather Hogg, Xiaochun Han, Kyoungja Hong, Stacy Remiszewski, Shirley Li, Ann Polonskaia, John Anthony Moliterni, Kang Le, Lin Gao, Nam T. Le, Christophe Michoud, A. Schutt, Shahid Tannu, Andrew F. Donnell, Shaoqing Chen, Louis J. Lombardo, Steven Gregory Mischke, Mark T. Dvorozniak, Yan Lou, Christine Tardell, Kenneth Carey Rupert, Doug Aguilar, Dave S. Solis
Publikováno v:
Journal of medicinal chemistry. 56(20)
The IAPs are key regulators of the apoptotic pathways and are commonly overexpressed in many cancer cells. IAPs contain one to three BIR domains that are crucial for their inhibitory function. The pro-survival properties of XIAP come from binding of
Autor:
Kang Le, Christophe Michoud, Robert T. Taylor, Christine Lukacs, Andrew D. Schutt, Lin Gao, Anthony Specian, Kenneth Carey Rupert, Stacy Remiszewski, Ann Polonskaia, Douglas Aguilar, Barry Goggin, John Anthony Moliterni, J. Heather Hogg, Liang Weiling, Xiaochun Han, Cheryl Janson, Louis J. Lombardo, Martin Weisel, Adrian J. Fretland, Steven Gregory Mischke, Norman Kong, Shirley Li, Robert Francis Kester, Andrew F. Donnell, Kyoungja Hong, Dave S. Solis, Karl Frank, Yan Lou
Publikováno v:
Journal of medicinal chemistry. 56(20)
XIAP is a key regulator of apoptosis, and its overexpression in cancer cells may contribute to their survival. The antiapoptotic function of XIAP derives from its BIR domains, which bind to and inhibit pro-apoptotic caspases. Most known IAP inhibitor
Autor:
Xiaochun Han, Yun-Chou Tan, Sue Jin, Paul J. Wagner, Alejandra Trejo, Parch Tivitmahaisoon, David Mark Rotstein, Bindu Goyal, Andreas Kuglstatter, Wylie Solang Palmer, Leyi Gong, Brian Wong, Patricia Tran, Alam Jahagir, Alice Chang, Joseph Dal Porto, Linghao Niu, Johaness Hermann, Fengrong Zuo, James Patrick Dunn, Karin Ann Stein, Heather Hogg, Muzaffar Alam, Ada Shao, David Michael Goldstein, Deborah Carol Reuter, Ferenc Makra, Gary Hsieh, Brad Loe, Lubov Filonova, Lubica Rapatova, Tania Silva
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(12)
A novel series of indole/indazole-aminopyrimidines was designed and synthesized with an aim to achieve optimal potency and selectivity for the c-Jun kinase family or JNKs. Structure guided design was used to optimize the series resulting in a signifi
Autor:
Leyi Gong, Gary Peltz, Pete William Dunten, Yun-Chou Tan, Zafrira Avnur, Don Hirschfeld, J. Heather Hogg
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(5)
Here we report on the discovery of a series of maleimides which have high potency and good selectivity for GSK-3β. The incorporation of polar groups afforded compounds with good bioavailability. The most potent compound 34 has an IC 50 of 0.6 nM for
Autor:
Woongki Kim, Tania Silva, Michael Garret Roepel, Klaus Klumpp, Denis John Kertesz, James Patrick Dunn, Pete William Dunten, Y. David Saito, Gabrielle Heilek, Taraneh Mirzadegan, Jahari Laurant Tracy, Zachary Kevin Sweeney, Amy S. Zhou, Todd R. Elworthy, Steven Swallow, Seth F. Harris, Harit Vora, Walter Huber, Donald Roy Hirschfeld, J. Heather Hogg, Xiaochun Han, Armando G. Villaseñor, Ann C. Kaiser, Yu Li
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(15)
A series of benzyl pyridazinones were evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Several members of this series showed good activity against the wild-type virus and NNRTI-resistant viruses. The binding of inhibitor 5
Autor:
Gong, Leyi, Hirschfeld, Don, Tan, Yun-Chou, Heather Hogg, J., Peltz, Gary, Avnur, Zafrira, Dunten, Pete
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2010 20(5):1693-1696
Publikováno v:
ChemInform. 35
As part of our investigation into the development of potent CCR3 antagonists, a series of piperidine analogues was designed and prepared. Exploration of the piperidine core examined both the basicity and the location of a nitrogen, as well as conform