Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Heather H. C. Lau"'
Autor:
Heather H. C. Lau, Ivan Martinez-Valbuena, Raphaella W. L. So, Surabhi Mehra, Nicholas R. G. Silver, Alison Mao, Erica Stuart, Cian Schmitt-Ulms, Bradley T. Hyman, Martin Ingelsson, Gabor G. Kovacs, Joel C. Watts
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Unique strains of α-synuclein aggregates have been postulated to underlie the spectrum of clinical and pathological presentations seen across the synucleinopathies. Whereas multiple system atrophy (MSA) is associated with a predominance of
Externí odkaz:
https://doaj.org/article/0a11f0c8776346f5aa6f04e52680ec2e
Autor:
Ivan Martinez-Valbuena, Naomi P. Visanji, Ain Kim, Heather H. C. Lau, Raphaella W. L. So, Sohaila Alshimemeri, Andrew Gao, Michael A. Seidman, Maria R. Luquin, Joel C. Watts, Anthony E. Lang, Gabor G. Kovacs
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-14 (2022)
Abstract Background Multiple system atrophy (MSA) is a neurodegenerative condition characterized by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and pyramidal features. Although the distribution of synucleinopathy corre
Externí odkaz:
https://doaj.org/article/a8896966164644b4a18d3e1c9d1ee7a0
Autor:
Alejandro Ruiz-Riquelme, Alison Mao, Marim M. Barghash, Heather H. C. Lau, Erica Stuart, Gabor G. Kovacs, K. Peter R. Nilsson, Paul E. Fraser, Gerold Schmitt-Ulms, Joel C. Watts
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer’s disease (AD) patients or transgenic AD mouse models seed cerebral Aβ deposition in a prion-like fashion. Within the br
Externí odkaz:
https://doaj.org/article/311ee78e40194926b8b50a33d61a9ceb
Autor:
Raphaella W. L. So, Sai Wai Chung, Heather H. C. Lau, Jeremy J. Watts, Erin Gaudette, Zaid A. M. Al-Azzawi, Jossana Bishay, Lilian Tsai-Wei Lin, Julia Joung, Xinzhu Wang, Gerold Schmitt-Ulms
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-16 (2019)
Abstract The adoption of CRISPR-Cas9 technology for functional genetic screens has been a transformative advance. Due to its modular nature, this technology can be customized to address a myriad of questions. To date, pooled, genome-scale studies hav
Externí odkaz:
https://doaj.org/article/3ec4297f568f430e9abc28d7d2b76c06
Autor:
Alejandro Ruiz-Riquelme, Heather H. C. Lau, Erica Stuart, Adrienn N. Goczi, Zhilan Wang, Gerold Schmitt-Ulms, Joel C. Watts
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)
Abstract The amyloid cascade hypothesis posits that the initiating event in Alzheimer’s disease (AD) is the aggregation and deposition of the β-amyloid (Aβ) peptide, which is a proteolytic cleavage product of the amyloid precursor protein (APP).
Externí odkaz:
https://doaj.org/article/e8779bde378d4e898068a96d4935bbd0
Publikováno v:
Acta Neuropathologica. 142:17-39
Reminiscent of the human prion diseases, there is considerable clinical and pathological variability in Alzheimer's disease, the most common human neurodegenerative condition. As in prion disorders, protein misfolding and aggregation is a hallmark fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e777644ce102fe0fc4d54518dfac9d3c
https://doi.org/10.1007/s00401-020-02201-2
https://doi.org/10.1007/s00401-020-02201-2
Autor:
Ivan Martinez-Valbuena, Naomi P. Visanji, Ain Kim, Heather H. C. Lau, Raphaella W. L. So, Sohaila Alshimemeri, Andrew Gao, Michael A. Seidman, Maria R. Luquin, Joel C. Watts, Anthony E. Lang, Gabor G. Kovacs
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-14 (2022)
Background Multiple system atrophy (MSA) is a neurodegenerative condition characterized by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and pyramidal features. Although the distribution of synucleinopathy correlates wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8c3695f709ee05b9a3926fff4566d9
https://pubmed.ncbi.nlm.nih.gov/35125105
https://pubmed.ncbi.nlm.nih.gov/35125105
Autor:
Naomi P. Visanji, Heather H. C. Lau, Gabor G. Kovacs, Ain Kim, Raphaella W. L. So, M. R. Luquin, Anthony E. Lang, Joel C. Watts, Ivan Martinez-Valbuena, Andrew Gao, Michael Seidman, Sohaila Alshimemeri
Severalin vitroandin vivofindings have consistently shown that α-synuclein derived from multiple system atrophy (MSA) subjects has more seeding capacity than Parkinson’s disease-derived α-synuclein. However, reliable detection of α-synuclein der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34bc413c75322a056d8350a383aa83f5
https://doi.org/10.1101/2021.08.10.455800
https://doi.org/10.1101/2021.08.10.455800
Autor:
K. Peter R. Nilsson, Joel C. Watts, Gabor G. Kovacs, Paul E. Fraser, Heather H. C. Lau, Gerold Schmitt-Ulms, Marim M Barghash, Alejandro Ruiz-Riquelme, Erica Stuart, Alison Mao
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
When injected into genetically modified mice, aggregates of the amyloid-beta (A beta) peptide from the brains of Alzheimers disease (AD) patients or transgenic AD mouse models seed cerebral A beta deposition in a prion-like fashion. Within the brain,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c80ba3ec2dadd4c5bf3ee415c543d3d
http://europepmc.org/articles/PMC8112054
http://europepmc.org/articles/PMC8112054
Autor:
Erica Stuart, Gerold Schmitt-Ulms, Zhilan Wang, Alejandro Ruiz-Riquelme, Heather H. C. Lau, Joel C. Watts, Adrienn N. Goczi
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
The amyloid cascade hypothesis posits that the initiating event in Alzheimer’s disease (AD) is the aggregation and deposition of the β-amyloid (Aβ) peptide, which is a proteolytic cleavage product of the amyloid precursor protein (APP). Mounting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3230dfb126aecf42b362987f80a8c4
http://link.springer.com/article/10.1186/s40478-018-0529-x
http://link.springer.com/article/10.1186/s40478-018-0529-x