Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Heather F. Johnston"'
Autor:
Mingfeng Zhang, Heather F. Johnston, Defu Zeng, Christine Shen, Kathleen Siswanto, Miao Wang, Tao Wu, Jeremy J. Racine, Ruishu Deng
Publikováno v:
The Journal of Immunology. 193:2005-2015
In nonautoimmune recipients, induction of mixed and complete chimerism with hematopoietic progenitor cells from MHC (HLA)-matched or -mismatched donors are effective approaches for induction of organ transplantation immune tolerance in both animal mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9bab3a4774b6d244da75e44e4d5cc03
https://doi.org/10.4049/jimmunol.1401137
https://doi.org/10.4049/jimmunol.1401137
Autor:
Xiong Ni, Stephen J. Forman, Andrew T. Chan, Heather F. Johnston, Yajing Xu, Tao Wu, Jeremy J. Racine, Kaniel Cassady, Defu Zeng
Publikováno v:
Biology of Blood and Marrow Transplantation. 20(8):1089-1103
Chronic graft-versus-host disease (cGVHD) is an autoimmune-like syndrome, and donor B cells play important roles in augmenting its pathogenesis. B cell–depleting anti-CD20 mAb has been administered before or after cGVHD onset for preventing or trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9964f4bdb313923c6611fb92fca880e
Autor:
Nainong Li, Kaniel Cassady, Defu Zeng, Stephen J. Forman, Wei He, Jeremy J. Racine, Heather F. Johnston, Ruishu Deng, Paul J. Martin, Can Liu, Xiaofan Li
Publikováno v:
Biology of Blood and Marrow Transplantation. 20(7):920-928
We reported previously that anti-CD3 mAb treatment before hematopoietic cell transplantation (HCT) prevented graft-versus-host disease (GVHD) and preserved graft-versus-leukemia (GVL) effects in mice. These effects were associated with downregulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813d1ad6ebe8d5a37b70adf36fee3157
Autor:
Tao Wu, Xiong Ni, Heather F. Johnston, Ivan Todorov, Jianmin Wang, Audrey Wang, Miao Wang, Ruishu Deng, Defu Zeng, Jeremy J. Racine, James S. Young
Publikováno v:
The Journal of Immunology. 191:488-499
Prevention of chronic graft-versus-host disease (cGVHD) remains a major challenge in allogeneic hematopoietic cell transplantation (HCT) owing to limited understanding of cGVHD pathogenesis and lack of appropriate animal models. In this study, we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d7b499fb4dcf2a0e73fb73035aad8d
https://doi.org/10.4049/jimmunol.1300657
https://doi.org/10.4049/jimmunol.1300657
Autor:
Defu Zeng, Tangsheng Yi, Yu-Hong Chen, Heather F. Johnston, Hongjun Liu, Jeremy J. Racine, James S. Young, Dongchang Zhao, Ivan Todorov, Audrey Wang, Xiaofan Li, Tao Wu
Publikováno v:
The Journal of Immunology. 189:222-233
We reported that both donor CD4+ T and B cells in transplants were required for induction of an autoimmune-like chronic graft-versus-host disease (cGVHD) in a murine model of DBA/2 donor to BALB/c recipient, but mechanisms whereby donor B cells augme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba8a210cb836d67b2ee9344137528c2
https://doi.org/10.4049/jimmunol.1200677
https://doi.org/10.4049/jimmunol.1200677
Autor:
Michael E. Barish, Heather F. Johnston, Marianne Z. Metz, Elizabeth Garcia, Stephen E. Kendall, Carlotta A. Glackin, Karen S. Aboody, Joseph Najbauer, Marisa Bowers, Seung U. Kim, Shan Li
Publikováno v:
Stem Cells. 26:1575-1586
The utility of neural stem cells (NSCs) has extended beyond regenerative medicine to targeted gene delivery, as NSCs possess an inherent tropism to solid tumors, including invasive gliomas. However, for optimal clinical implementation, an understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4a9d37f615decfc7bc6ec4f552306a
https://doi.org/10.1634/stemcells.2007-0887
https://doi.org/10.1634/stemcells.2007-0887
Autor:
Ivan Todorov, Fouad Kandeel, Xiaoping Song, Defu Zeng, Hongjun Liu, Heather F. Johnston, Can Liu, Stephen J. Forman, Alina Avakian-Mansoorian, Indu Nair, Christine Shen, Xiaofan Li, Mark A. Atkinson, Jeremy J. Racine, Brian S. Wilson, Miao Wang
Publikováno v:
Science translational medicine. 4(133)
Type 1 diabetes (T1D) results from an autoimmune destruction of insulin-producing β cells. Currently, islet transplantation is the only curative therapy for late-stage T1D, but the beneficial effect is limited in its duration, even under chronic imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374360d4926a292674f1bee8f0aa7c14
https://pubmed.ncbi.nlm.nih.gov/22572878
https://pubmed.ncbi.nlm.nih.gov/22572878
Autor:
Defu Zeng, Sheng Yao, Xiaofan Li, Yu-Hong Chen, Lieping Chen, James S. Young, Lin Wang, Tangsheng Yi, Stephen J. Forman, Ivan Todorov, Hongjun Liu, Dongchang Zhao, Heather F. Johnston
Foxp3+ regulatory T (Treg) cells include thymic-derived natural Treg and conventional T-derived adaptive Treg cells. Both are proposed to play important roles in downregulating inflammatory immune responses. However, the mechanisms of Treg expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded32d976d522445d35e1f7dff15025a
https://europepmc.org/articles/PMC3786569/
https://europepmc.org/articles/PMC3786569/
Autor:
Heather F. Johnston, Fouad Kandeel, Lin Wang, Gong Du, Stephen J. Forman, James S. Young, Dongchang Zhao, Ivan Todorov, Defu Zeng, Lieping Chen, Daniel Huang, Yoichiro Iwakura, Dale T. Umetsu, Ying Chen, Tangsheng Yi
In acute graft-versus-host disease (GVHD), naive donor CD4(+) T cells recognize alloantigens on host antigen-presenting cells and differentiate into T helper (Th) subsets (Th1, Th2, and Th17 cells), but the role of Th subsets in GVHD pathogenesis is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb6d284fb2701c361c1daf54f23774f
https://europepmc.org/articles/PMC2756212/
https://europepmc.org/articles/PMC2756212/
Publikováno v:
Blood. 124:3817-3817
We recently reported that in a chronic graft versus host disease (GVHD) model of DBA/2 donor to MHC-matched BALB/c recipient, donor CD4+ T and B cell interaction resulted in not only hyperglobulinemia and glomerulonephritis but also scleroderma (J. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f08f04f7d972f5a7fba19d221b3b666
https://doi.org/10.1182/blood.v124.21.3817.3817
https://doi.org/10.1182/blood.v124.21.3817.3817