Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Heather Eckart"'
Autor:
Alan Selewa, Kaixuan Luo, Michael Wasney, Linsin Smith, Xiaotong Sun, Chenwei Tang, Heather Eckart, Ivan P. Moskowitz, Anindita Basu, Xin He, Sebastian Pott
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Genome-wide association studies (GWAS) have linked hundreds of loci to cardiac diseases. However, in most loci the causal variants and their target genes remain unknown. We developed a combined experimental and analytical approach that integ
Externí odkaz:
https://doaj.org/article/939b6521d6c3426eaa0f049ed265fe03
Autor:
Bingqing Xie, Susan Olalekan, Rebecca Back, Naa Asheley Ashitey, Heather Eckart, Anindita Basu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2024)
Ovarian cancer is a highly heterogeneous disease consisting of at least five different histological subtypes with varying clinical features, cells of origin, molecular composition, risk factors, and treatments. While most single-cell studies have foc
Externí odkaz:
https://doaj.org/article/01bfaefd279a408a89d832fd9ef6569e
Autor:
Ryan Dohn, Bingqing Xie, Rebecca Back, Alan Selewa, Heather Eckart, Reeta Prusty Rao, Anindita Basu
Publikováno v:
Vaccines, Vol 10, Iss 1, p 30 (2021)
Advances in high-throughput single-cell RNA sequencing (scRNA-seq) have been limited by technical challenges such as tough cell walls and low RNA quantity that prevent transcriptomic profiling of microbial species at throughput. We present microbial
Externí odkaz:
https://doaj.org/article/82c9a84bb41c4501b95d261b6c00f934
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-13 (2017)
Abstract Background Genome-wide quantification of enhancer activity in the human genome has proven to be a challenging problem. Recent efforts have led to the development of powerful tools for enhancer quantification. However, because of genome size
Externí odkaz:
https://doaj.org/article/cd94f2588bc54cd6aa483973421b8507
Autor:
Ernst Lengyel, Yan Li, Melanie Weigert, Lisha Zhu, Heather Eckart, Melissa Javellana, Sarah Ackroyd, Jason Xiao, Susan Olalekan, Dianne Glass, Shilpa Iyer, Agnes Julia Bilecz, Ricardo Lastra, Mengjie Chen, Anindita Basu
SummaryAs part of the Human Cell Atlas initiative, we generated transcriptomic (scRNA-seq; 86,708 cells) and regulatory (scATAC-seq; 59,118 cells) profiles of the normal postmenopausal ovary and fallopian tube (FT) at single-cell resolution. In the F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfbdd841e2b96f665e6f14ec4629b319
https://doi.org/10.1101/2022.08.04.502826
https://doi.org/10.1101/2022.08.04.502826
Autor:
Kaelan R Sullivan, Sebastian Pott, Heather Eckart, Anindita Basu, Michael Bressan, Mervenaz Koska, Ivan P. Moskowitz, Alexander Guzzetta, Rebecca Back, Stephanie Lozano, Megan Rowton, Hunter Hidalgo, Jessica Jacobs-Li, Junghun Kweon, Andrew D. Hoffmann, Anne M. Moon
Publikováno v:
Proc Natl Acad Sci U S A
The mechanisms used by embryos to pattern tissues across their axes has fascinated developmental biologists since the founding of embryology. Here, using single-cell technology, we interrogate complex patterning defects and define a Hedgehog (Hh)–f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585fd6373d1168e1e1d60a1bac693b0e
https://doi.org/10.1073/pnas.1914167117
https://doi.org/10.1073/pnas.1914167117
Autor:
Anindita Basu, Sebastian Pott, Bingqing Xie, Alan Selewa, Yoav Gilad, Ryan Dohn, Heather Eckart, Reem Elorbany, Eric Gauchat, Katherine Rhodes, Stephanie Lozano, Jonathan E. Burnett
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
A comprehensive reference map of all cell types in the human body is necessary for improving our understanding of fundamental biological processes and in diagnosing and treating disease. High-throughput single-cell RNA sequencing techniques have emer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fe58ed47525d097393a0db8aca7114
http://link.springer.com/article/10.1038/s41598-020-58327-6
http://link.springer.com/article/10.1038/s41598-020-58327-6
Autor:
Alan Selewa, Kaixuan Luo, Michael Wasney, Linsin Smith, Xiaotong Sun, Chenwei Tang, Heather Eckart, Ivan P. Moskowitz, Anindita Basu, Xin He, Sebastian Pott
Genome-wide association studies (GWAS) have linked hundreds of loci to cardiac diseases. However, in most loci the causal variants and their target genes remain unknown. We developed a combined experimental and analytical approach that integrates sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::affd3c6eee206ea02a59bc8286ae84e0
https://doi.org/10.1101/2022.02.02.22270312
https://doi.org/10.1101/2022.02.02.22270312
This protocol provides a procedure for human intestinal organoid dissociation into a single cell suspension and nuclei isolation prior to Single Cell ATAC-Sequencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eaa5c0630d67f99fa8d5c997373a0b3
https://doi.org/10.17504/protocols.io.bmdbk22n
https://doi.org/10.17504/protocols.io.bmdbk22n
Publikováno v:
Cell reports. 35(8)
Summary Understanding the cellular composition of the tumor microenvironment and the interactions of the cells is essential to the development of successful immunotherapies in cancer. We perform single-cell RNA sequencing (scRNA-seq) of 9,885 cells i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8453b833ac71e3a66b2f378628f28e3
https://pubmed.ncbi.nlm.nih.gov/34038734
https://pubmed.ncbi.nlm.nih.gov/34038734