Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Heather E. Tibbles"'
Autor:
Taracad K. Venkatachalam, Douglas Erbeck, Fatih M. Uckun, Xing-Ping Liu, Sanjive Qazi, Ilker Dibirdik, Heather E. Tibbles, Alexei O. Vassilev
Publikováno v:
Arzneimittelforschung. 54:715-731
The novel cytotoxic nucleoside analog Compound 003 (3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate], CAS 149560-32-7) prevented bipolar mitotic spindle assembly and caused a G2 arrest in human cancer cells. Compound 003 was very well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876803f4c3f1264b8981dfbf91aadd95
https://doi.org/10.1055/s-0031-1297029
https://doi.org/10.1055/s-0031-1297029
Autor:
Suzanne Downs, Olga O. Grigoriants, Alexey Benyumov, Alexei O. Vassilev, Taracad K. Venkatachalam, Darin Dumezb, Fatih M. Uckun, Heather E. Tibbles
Publikováno v:
Arzneimittelforschung. 55:114-122
The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo model. DDE46 blocked the cell division at the 2-cell stage of the embryoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1de9817df45944f82b95c7a1b9fcede
https://doi.org/10.1055/s-0031-1296832
https://doi.org/10.1055/s-0031-1296832
Autor:
Fatih M. Uckun, Alexei O. Vassilev, Douglas Erbeck, Sanjive Qazi, Taracad K. Venkatachalam, Heather E. Tibbles
Publikováno v:
Arzneimittelforschung. 57:320-329
Familial adenomatous polyposis (FAP) is associated with germ-line mutations in the tumor suppressor gene, adenomatous polyposis coli (APC) located on chromosome 5q21. Multiple intestinal neoplasia (Min) in mice resembles FAP in humans, resulting from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34420cd853484dc5de82ab3d28a0f545
https://doi.org/10.1055/s-0031-1296626
https://doi.org/10.1055/s-0031-1296626
Publikováno v:
Arzneimittelforschung. 57:483-496
N'-[2-(2-Thiophene)ethyl]-N'-[2-(5bromopyridyl)]thiourea (CAS 258340-15-7, HI-443) is a potent non-nucleoside inhibitor of HIV reverse transcriptase (NNRTI) that was rationally designed as a candidate anti-HIV agent. The purpose of the present study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901d205ca8d9b96a0cdc2dbdf847e17e
https://doi.org/10.1055/s-0031-1296636
https://doi.org/10.1055/s-0031-1296636
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 7:624-632
Targeting Brutons tyrosine kinase (BTK) with a small molecule inhibitor may be useful in treatment of BTK-expressing malignancies because of the anti-apoptotic function of BTK in cancer cells. Furthermore, BTK inhibitors also exhibit anti-thrombotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b9e4c079df3dc8c372f902f1e5e092
https://doi.org/10.2174/187152007784111331
https://doi.org/10.2174/187152007784111331
Autor:
Darin D. DuMez, Heather E. Tibbles, Taracad K. Venkatachalam, Alexei O. Vassilev, Fatih M. Uckun
Publikováno v:
Current Drug Targets. 7:327-343
Multifunctional rational drug design of protein tyrosine kinases inhibitors allows a potent drug to be utilized to treat more than one disease for greater patient benefits. Many protein tyrosine kinases (PTK), including Janus kinase 3 (JAK3) and Brut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8149932e3f6557e34c0884a7414b70e5
https://doi.org/10.2174/138945006776054997
https://doi.org/10.2174/138945006776054997
Publikováno v:
Oncogene. 22:2504-2514
Sequence analysis of the noncoding first exon (exon 1) of the Syk gene demonstrated the presence of a previously cloned CpG island (GenBank #Z 65706). Transient transfection analysis in Daudi cells demonstrated promoter activity (18-fold increase ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e449d4e9d02f8a89566f6dd0c29a7f
https://doi.org/10.1038/sj.onc.1206313
https://doi.org/10.1038/sj.onc.1206313
Autor:
Michael A. Hupke, Fatih M. Uckun, Heather E. Tibbles, Alexei O. Vassilev, Christopher S. Navara
Publikováno v:
Biochemical and Biophysical Research Communications. 292:987-991
Ligation of thrombopoietin (TPO) to the platelet c-Mpl receptor induces numerous biochemical pathways in the absence of aggregation. Two forms of recombinant TPO are currently in clinical trials for the treatment of thrombocytopenia. This study focus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbca94fa07fd74c65abce042988fcd2
https://doi.org/10.1006/bbrc.2002.6759
https://doi.org/10.1006/bbrc.2002.6759
Publikováno v:
Leukemia & Lymphoma. 43:1461-1467
Actinomycin D, a transcriptional inhibitor, was found to inhibit platelet potentiation by thrombopoietin (TPO), suggesting that TPO stimulation of platelets involves mitochondrial transcription. We sought to determine a possible role for leukemia-ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fe65c21e5005c352d678c4e0fa46f1
https://doi.org/10.1080/1042819022386716
https://doi.org/10.1080/1042819022386716
Publikováno v:
Leukemia & Lymphoma. 43:2165-2170
Here, we report that the calcium ionophore ionomycin induces a massive Ca2+-dependent apoptosis in wildtype DT-40 chicken B lymphoma cells, as well as in BTK-deficient, PLCgamma2-deficient and IP3 receptor-deficient DT-40 cells, but not in LYN- or SY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6502564435409362d5044f082a90f0e
https://doi.org/10.1080/1042819021000032935
https://doi.org/10.1080/1042819021000032935