Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Heather E. Murrey"'
Autor:
Mark S. Tichenor, John J. M. Wiener, Navin L. Rao, Genesis M. Bacani, Jianmei Wei, Charlotte Pooley Deckhut, J. Kent Barbay, Kevin D. Kreutter, Leon Chang, Kathleen W. Clancy, Heather E. Murrey, Weixue Wang, Kay Ahn, Michael Huber, Elizabeth Rex, Kevin J. Coe, Jiejun Wu, Haopeng Rui, Kia Sepassi, Marcello Gaudiano, Mariette Bekkers, Ivo Cornelissen, Kathryn Packman, Mark Seierstad, Christos Xiouras, Scott D. Bembenek, Richard Alexander, Cynthia Milligan, Sriram Balasubramanian, Alec D. Lebsack, Jennifer D. Venable, Ulrike Philippar, James P. Edwards, Gavin Hirst
Publikováno v:
Journal of Medicinal Chemistry. 65:14326-14336
Bruton's tyrosine kinase (BTK) is a Tec family kinase that plays an essential role in B-cell receptor (BCR) signaling as well as Fcγ receptor signaling in leukocytes. Pharmacological inhibition of BTK has been shown to be effective in treating hemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b6932f837c19dc6e82c72e8534354a
https://doi.org/10.1021/acs.jmedchem.2c01026
https://doi.org/10.1021/acs.jmedchem.2c01026
Autor:
Jennifer D. Venable, Weixue Wang, Jianmei Wei, Heather E. Murrey, Mark S. Tichenor, Kristi A. Leonard, Michael Huber, Alec D. Lebsack, Genesis M. Bacani, Scott D. Bembenek, Kay Ahn, J. Kent Barbay, Leon Chang, Kevin D. Kreutter, Navin Rao, Charlotte Pooley Deckhut, Jiejun Wu, Kevin J. Coe, Elizabeth B. Rex, John J. M. Wiener, James P. Edwards, Mark Seierstad
Publikováno v:
ACS Med Chem Lett
[Image: see text] Bruton’s tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase that plays a critical role in the activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types in the pathology of autoimmune disorders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422ec59592fb7660a28bf2fbdb3405aa
https://doi.org/10.1021/acsmedchemlett.1c00044
https://doi.org/10.1021/acsmedchemlett.1c00044
Autor:
Joseph M. Fox, Edward Guilmette, Christopher W. am Ende, Douglas S. Johnson, Yinzhi Fang, Joshua C. Judkins, Li Di, Joel W. Schwartz, T. Eric Ballard, Heather E. Murrey, Keith Riccardi
Publikováno v:
Journal of the American Chemical Society
Bioorthogonal reactions, including the strain-promoted azide-alkyne cycloaddition (SPAAC) and inverse electron demand Diels-Alder (iEDDA) reactions, have become increasingly popular for live-cell imaging applications. However, the stability and react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a108a7ac19ee870fe7ac2db9bcffaa
http://europepmc.org/articles/PMC4572613
http://europepmc.org/articles/PMC4572613
Autor:
Christopher W. am Ende, Kieran F. Geoghegan, T. Eric Ballard, Heather E. Murrey, Douglas S. Johnson
Publikováno v:
MedChemComm. 5:321-327
We have developed a suite of clickable γ-secretase active site-directed dual-photoaffinity probes possessing photoactivatable benzophenones that are located within the inhibitor scaffold as well as spaced away from the core by a linker. Through phot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::421f4613b485aa3eddf7e26421c320c5
https://doi.org/10.1039/c3md00283g
https://doi.org/10.1039/c3md00283g
Autor:
Christopher W. am Ende, Kelly R. Bales, Douglas S. Johnson, Kwangwook Ahn, Heather E. Murrey, Christina J. Crump, Nikolay Pozdnyakov, Martin Pettersson, T. Eric Ballard, Yue-Ming Li
Publikováno v:
Journal of Biological Chemistry. 288:9710-9720
γ-Secretase is an intramembrane aspartyl protease that cleaves the amyloid precursor protein to produce neurotoxic β-amyloid peptides (i.e. Aβ42) that have been implicated in the pathogenesis of Alzheimer disease. Small molecule γ-secretase modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be67af06cfe100c03f2092ad6d781819
https://doi.org/10.1074/jbc.m112.398602
https://doi.org/10.1074/jbc.m112.398602
Autor:
Steven E. Domino, Linda C. Hsieh-Wilson, Heather E. Murrey, Scott B. Ficarro, Eric C. Peters, Chithra Krishnamurthy
Publikováno v:
Biochemistry
Fucose-alpha(1-2)-galactose [Fucalpha(1-2)Gal] sugars have been implicated in the molecular mechanisms that underlie neuronal development, learning, and memory. However, an understanding of their precise roles has been hampered by a lack of informati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912c26810b403bb3f66c10e7c17aa174
https://doi.org/10.1021/bi900640x
https://doi.org/10.1021/bi900640x
Autor:
Tsu-Shuen Tsao, Heather E. Murrey, John E. Heuser, Harvey F. Lodish, Christopher Hug, Eva Tomas, David H. Lee, Neil B. Ruderman
Publikováno v:
Journal of Biological Chemistry. 278:50810-50817
Acrp30/adiponectin is an adipocyte-derived serum protein with important roles in regulation of lipid and glucose metabolism, but which of its isoforms are biologically active remains controversial. We addressed this issue by first characterizing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cd2e112c920113e1c192b249f3b933d
https://doi.org/10.1074/jbc.m309469200
https://doi.org/10.1074/jbc.m309469200
Autor:
Heather E. Murrey, Martin Pettersson, Li Yueming, Nikolay Pozdnyakov, Doug Johnson, Christina J. Crump, Kelly R. Bales
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2f588cb5072005166037034d3fef54d
https://doi.org/10.1016/j.jalz.2013.04.110
https://doi.org/10.1016/j.jalz.2013.04.110
Autor:
Kelly R. Bales, Yue-Ming Li, Nikolay Pozdnyakov, Heather E. Murrey, Martin Pettersson, Douglas S. Johnson, Christina J. Crump
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32543fc9c641215c5d1d2751ce30e6a2
https://doi.org/10.1096/fasebj.27.1_supplement.lb73
https://doi.org/10.1096/fasebj.27.1_supplement.lb73
Publikováno v:
ChemInform. 39
The cell surface displays a complex array of oligosaccharides, glycoproteins, and glycolipids. This diverse mixture of glycans contains a wealth of information, modulating a wide range of processes such as cell migration, proliferation, transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fa7a51dbe5a96638faf01ab62c98ec6
https://doi.org/10.1002/chin.200835270
https://doi.org/10.1002/chin.200835270