Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Heather E. Fleming"'
Publikováno v:
EBioMedicine, Vol 38, Iss , Pp 248-256 (2018)
Background: Respiratory tract infections represent a significant public health risk, and timely and accurate detection of bacterial infections facilitates rapid therapeutic intervention. Furthermore, monitoring the progression of infections after int
Externí odkaz:
https://doaj.org/article/3578a4336fa74b4b97475abd95d3814b
Publikováno v:
ACS Nano. 16:15779-15791
Antimicrobial peptides (AMPs) constitute a promising class of alternatives to antibiotics to curb antimicrobial resistance. Nonetheless, their utility as a systemic agent is hampered by short circulation time and toxicity. Infection sites, analogous
Autor:
Liangliang Hao, Renee T. Zhao, Nicole L. Welch, Edward Kah Wei Tan, Qian Zhong, Nour Saida Harzallah, Chayanon Ngambenjawong, Henry Ko, Heather E. Fleming, Pardis C. Sabeti, Sangeeta N. Bhatia
Publikováno v:
Nature Nanotechnology.
Synthetic biomarkers, bioengineered sensors that generate molecular reporters in diseased microenvironments, represent an emerging paradigm in precision diagnostics. Despite the utility of DNA barcodes as a multiplexing tool, their susceptibility to
Autor:
Heather E. Fleming, Sangeeta N. Bhatia, Timothy K. Lu, Lior Nissim, Adina Binder-Nissim, Ava P. Soleimany, Jiang He
Publikováno v:
ACS Synthetic Biology. 10:2231-2242
The integration of nanotechnology and synthetic biology could lay the framework for new classes of engineered biosensors that produce amplified readouts of disease states. As a proof-of-concept demonstration of this vision, here we present an enginee
Autor:
Frank B. Gertler, Olivia J. Kelada, Emilia M Pulver, Sangeeta N. Bhatia, Henry Ko, Heather E. Fleming, Renee T. Zhao, Nazanin Rohani, Liangliang Hao, Howard Mak
Publikováno v:
Nature Materials. 20:1440-1448
Therapeutic outcomes in oncology may be aided by precision diagnostics that offer early detection, localization and the opportunity to monitor response to therapy. Here, we report a multimodal nanosensor engineered to target tumours through acidosis,
Autor:
Arnav, Chhabra, H-H Greco, Song, Katarzyna A, Grzelak, William J, Polacheck, Heather E, Fleming, Christopher S, Chen, Sangeeta N, Bhatia
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Liver regeneration is a well-orchestrated process that is typically studied in animal models. Although previous animal studies have offered many insights into liver regeneration, human biology is less well understood. To this end, we developed a thre
Publikováno v:
Med. 2:118-121
During the SARS-CoV-2 pandemic, experimental research groups face a unique challenge: how to train undergraduates without access to labs. We share our experience developing entirely virtual undergraduate research internships and make a case for virtu
Autor:
Liliana Mancio-Silva, Nil Gural, Alex K. Shalek, Niketa Nerurkar, Sandra March, Jetsumon Sattabongkot, Stuart S. Levine, Travis K. Hughes, Marc H. Wadsworth, Vincent L. Butty, Sangeeta N. Bhatia, Charles A. Whittaker, Heather E. Fleming, Wanlapa Roobsoong
SUMMARYMalaria-causing P. vivax parasites can linger in the human liver for weeks to years, and then reactivate to cause recurrent blood-stage infection. While an important target for malaria eradication, little is known about the molecular features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::662ac7caed4e1810d62985083fda84c2
https://doi.org/10.1101/2021.09.01.454555
https://doi.org/10.1101/2021.09.01.454555
Autor:
Liliana Mancio-Silva, Nil Gural, Eliana Real, Marc H. Wadsworth, Vincent L. Butty, Sandra March, Niketa Nerurkar, Travis K. Hughes, Wanlapa Roobsoong, Heather E. Fleming, Charlie A. Whittaker, Stuart S. Levine, Jetsumon Sattabongkot, Alex K. Shalek, Sangeeta N. Bhatia
Publikováno v:
Cell Host & Microbe
Cell Host & Microbe, 2022, 30 (7), pp.1048-1060.e5. ⟨10.1016/j.chom.2022.03.034⟩
Cell Host & Microbe, 2022, 30 (7), pp.1048-1060.e5. ⟨10.1016/j.chom.2022.03.034⟩
International audience; Malaria-causing Plasmodium vivax parasites can linger in the human liver for weeks to years and reactivate to cause recurrent blood-stage infection. Although they are an important target for malaria eradication, little is know
Autor:
Sangeeta N. Bhatia, Liangliang Hao, Renee Zhao, Henry Ko, Heather E. Fleming, Chayanon Ngambenjawong
Synthetic biomarkers, exogenous probes that generate molecular reporters, represent an emerging paradigm in precision diagnostics with applications across infectious and noncommunicable diseases. These methods use multiplexing strategies to provide t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::053c1452b4e467dbab0bc94ecaddff28
https://doi.org/10.21203/rs.3.rs-636557/v1
https://doi.org/10.21203/rs.3.rs-636557/v1