Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Heather Doviak"'
Autor:
Soichi Sano, Ying Wang, Hayato Ogawa, Keita Horitani, Miho Sano, Ariel H. Polizio, Anupreet Kour, Yoshimitsu Yura, Heather Doviak, Kenneth Walsh
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
Therapy-related clonal hematopoiesis (t-CH) is often observed in cancer survivors. This form of clonal hematopoiesis typically involves somatic mutations in driver genes that encode components of the DNA damage response and confer hematopoietic stem
Externí odkaz:
https://doaj.org/article/9b158d293a96473d8b0c4c3bf70e10de
Autor:
Stephanie L. Thorn, James A. Shuman, Mitchel R. Stacy, Brendan P. Purcell, Heather Doviak, Jason A. Burdick, Francis G. Spinale, Albert J. Sinusas
Publikováno v:
Journal of Cardiovascular Translational Research. 16:155-165
Autor:
Yimu Lai, Heather Doviak, Valerie K. Laney, Lisa A. Freeburg, Kia N. Zellars, Laura B. Snyder, Francis G. Spinale, Lydia E. Matesic, Amber Moore
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 321:H976-H984
Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and is accompanied by abnormal extracellular matrix (ECM) accumulation. It is now recognized that the ECM is a dy
Autor:
Kyung-Duk Min, Keita Horitani, Ana Filipa Domingues, Soichi Sano, Nicholas W. Chavkin, Emiri Miura-Yura, Ying Wang, Hayato Ogawa, Kenneth Walsh, George Philippos, Miho Sano, Ariel H. Polizio, Katharina Boroviak, Megan A Evans, George S. Vassiliou, Yasufumi Katanasaka, Heather Doviak, Yoshimitsu Yura
Publikováno v:
Circulation Research. 129:684-698
Rationale: Cancer therapy can be associated with short- and long-term cardiac dysfunction. Patients with cancer often exhibit therapy-related clonal hematopoiesis (t-CH), an aggressive form of clonal hematopoiesis that can result from somatic mutatio
Autor:
Yoshimitsu Yura, Ying Wang, Keita Horitani, Megan A Evans, Heather Doviak, Kenneth Walsh, Hayato Ogawa, Emiri Miura-Yura, Soichi Sano
Publikováno v:
Cardiovasc Res
Clonal haematopoiesis (CH) is a phenomenon whereby somatic mutations confer a fitness advantage to haematopoietic stem and progenitor cells (HSPCs) and thus facilitate their aberrant clonal expansion. These mutations are carried into progeny leucocyt
Autor:
Kia N. Zellars, Eva Romito, Heather Doviak, Tae-Weon Lee, Gregory L. Brower, Parker D. Freels, Stephen W. Smith, David C Lobb, James A Shuman, Lisa A. Freeburg, Francis G. Spinale, Aarif Y. Khakoo, Jason W. O’Neill
Publikováno v:
J Pharmacol Exp Ther
Infarct expansion can occur after myocardial infarction (MI), which leads to adverse left ventricular (LV) remodeling and failure. An imbalance between matrix metalloproteinase (MMP) induction and tissue inhibitors of MMPs (TIMPs) can accelerate this
Autor:
Heather Doviak, Amber Moore, William M. Torres, Michael R. Zile, Abigail C. Hoenes, Shayne C. Barlow, Lisa A. Freeburg, Tarek Shazly, Francis G. Spinale
Publikováno v:
JACC: Basic to Translational Science. 5:463-480
Summary This study assessed the regional changes in myocardial geometry, microstructure, mechanical behavior, and properties that occur in response to progressive left ventricular pressure overload (LVPO) in a large animal model. Using an index of lo
Autor:
Stephanie L, Thorn, James A, Shuman, Mitchel R, Stacy, Brendan P, Purcell, Heather, Doviak, Jason A, Burdick, Francis G, Spinale, Albert J, Sinusas
Publikováno v:
Journal of cardiovascular translational research.
Following myocardial infarction (MI), maladaptive upregulation of matrix metalloproteinase (MMP) alters extracellular matrix leading to cardiac remodeling. Intramyocardial hydrogel delivery provides a vehicle for local delivery of MMP tissue inhibito
Autor:
Laura B, Snyder, Yimu, Lai, Heather, Doviak, Lisa A, Freeburg, Valerie K, Laney, Amber, Moore, Kia N, Zellars, Lydia E, Matesic, Francis G, Spinale
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 321(5)
Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and accompanied by abnormal extracellular matrix (ECM) accumulation. The E
Autor:
Yoshimitsu, Yura, Emiri, Miura-Yura, Yasufumi, Katanasaka, Kyung-Duk, Min, Nicholas, Chavkin, Ariel H, Polizio, Hayato, Ogawa, Keita, Horitani, Heather, Doviak, Megan A, Evans, Miho, Sano, Ying, Wang, Katharina, Boroviak, George, Philippos, Ana Filipa, Domingues, George, Vassiliou, Soichi, Sano, Kenneth, Walsh
Publikováno v:
Circulation research. 129(6)
[Figure: see text].