Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Heather Donaghy"'
Autor:
Kelly J. McKelvey, Amanda L. Hudson, Heather Donaghy, Shihani P. Stoner, Helen R. Wheeler, Connie I. Diakos, Viive M. Howell
Publikováno v:
Radiation Oncology, Vol 17, Iss 1, Pp 1-14 (2022)
Abstract Background Radiotherapy (RT) is a mainstay of treatment for patients with glioblastoma (GB). Early clinical trials show that short course hypofractionation showed no survival benefit compared to conventional regimens with or without temozolo
Externí odkaz:
https://doaj.org/article/56a73af82ee04918a6c8248c8a15a583
Autor:
Archana Prashanth, Heather Donaghy, Shihani P. Stoner, Amanda L. Hudson, Helen R. Wheeler, Connie I. Diakos, Viive M. Howell, Georges E. Grau, Kelly J. McKelvey
Publikováno v:
Cancers, Vol 13, Iss 5, p 955 (2021)
Background: High grade gliomas (HGG) are incapacitating and prematurely fatal diseases. To overcome the poor prognosis, novel therapies must overcome the selective and restricted permeability of the blood–brain barrier (BBB). This study critically
Externí odkaz:
https://doaj.org/article/475f52d25acc46df9edb8648f45e6bda
Autor:
Heather Donaghy, George Rozis, Martin Goodier, Linda Klavinskis, Frances Gotch, Steven Patterson, Adel Benlahrech
Publikováno v:
Sensors, Vol 9, Iss 1, Pp 386-403 (2009)
Human plasmacytoid dendritic cells secrete high levels of IFNa and are thus implicated in the activation of NK cells. Activated NK cells are characterised by the up-regulation of CD69 and MHC class II DR expression, secretion of IFN g and enhanced cy
Externí odkaz:
https://doaj.org/article/84869ffc6bd84f3794e13c5897224245
Autor:
Sarah K. Mercier, Heather Donaghy, Rachel A. Botting, Stuart G. Turville, Andrew N. Harman, Najla Nasr, Hong Ji, Ulrike Kusebauch, Luis Mendoza, David Shteynberg, Kerrie Sandgren, Richard J. Simpson, Robert L. Moritz, Anthony L. Cunningham
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/180ed81c7c9b4da485a8b723fefe9145
Autor:
Sarah K Mercier, Heather Donaghy, Rachel A Botting, Stuart G Turville, Andrew N Harman, Najla Nasr, Hong Ji, Ulrike Kusebauch, Luis Mendoza, David Shteynberg, Kerrie Sandgren, Richard J Simpson, Robert L Moritz, Anthony L Cunningham
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003700 (2013)
HIV-1 is taken up by immature monocyte derived dendritic cells (iMDDCs) into tetraspanin rich caves from which the virus can either be transferred to T lymphocytes or enter into endosomes resulting in degradation. HIV-1 binding and fusion with the DC
Externí odkaz:
https://doaj.org/article/b648816bfe1347eea9fbd8993249f6ff
Autor:
Heather Donaghy
Publikováno v:
mAbs
Antibody-drug conjugates (ADCs) represent a new class of cancer therapeutics. Their design involves a tumor-specific antibody, a linker and a cytotoxic payload. They were designed to allow specific targeting of highly potent cytotoxic agents to tumor
Autor:
Najla Nasr, Andrew R. Lloyd, Elizabeth Keoshkerian, Valerie Marsden, Heather Donaghy, Anthony L. Cunningham, Andrew N. Harman, Steven Merten, Kirstie M. Bertram
Publikováno v:
The Journal of Immunology. 194:4438-4445
Prior HSV-2 infection enhances the acquisition of HIV-1 >3-fold. In genital herpes lesions, the superficial layers of stratified squamous epithelium are disrupted, allowing easier access of HIV-1 to Langerhans cells (LC) in the epidermis and perhaps
Autor:
Najla Nasr, Stuart Turville, Andrew N. Harman, John Wilkinson, Michael R. Beard, Thomas K. Wright, Dharshini Rambukwelle, Christopher R. Bye, Susan Maddocks, Anthony L. Cunningham, Heather Donaghy, Karla J. Helbig, Natalie Woolger
Publikováno v:
Blood. 120:778-788
Macrophages are key target cells for HIV-1. HIV-1BaL induced a subset of interferon-stimulated genes in monocyte-derived macrophages (MDMs), which differed from that in monocyte-derived dendritic cells and CD4 T cells, without inducing any interferon
Autor:
Joey Lai, Stuart Turville, Shamith A. Samarajiwa, Sarah K. Mercier, Michael Gale, Kate L. Jones, Lachlan Robert Gray, Najla Nasr, Melissa J Churchill, Arjun Rustagi, Helen E. Cumming, Johnson Mak, Heather Donaghy, Andrew N. Harman, Valerie Marsden, Anthony L. Cunningham, Paul J. Hertzog
Publikováno v:
Blood. 118:298-308
Many viruses have developed mechanisms to evade the IFN response. Here, HIV-1 was shown to induce a distinct subset of IFN-stimulated genes (ISGs) in monocyte-derived dendritic cells (DCs), without detectable type I or II IFN. These ISGs all containe
Publikováno v:
Current Opinion in Microbiology. 13:524-529
Viruses manipulate the function of dendritic cells (DCs) to enhance their entry, spread, survival and transmission. This review summarises recently published work identifying how viruses alter the expression of receptors, antiviral molecules, disrupt