Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Heather Derocher"'
Autor:
Joanne A. Hammill, Jacek M. Kwiecien, Anna Dvorkin-Gheva, Vivian W.C. Lau, Christopher Baker, Ying Wu, Ksenia Bezverbnaya, Craig Aarts, Christopher W. Heslen, Galina F. Denisova, Heather Derocher, Katy Milne, Brad H. Nelson, Jonathan L. Bramson
Publikováno v:
Molecular Therapy: Oncolytics, Vol 17, Iss , Pp 278-292 (2020)
Tumor-targeted chimeric antigen receptor (CAR)-engineered T lymphocytes (CAR-T cells) have demonstrated striking clinical success, but their use has been associated with a constellation of toxicities. A better understanding of the pathogenesis of the
Externí odkaz:
https://doaj.org/article/0b7d3e652e9749189e9a98e4bde2c565
Autor:
Christopher W. Helsen, Joanne A. Hammill, Vivian W. C. Lau, Kenneth A. Mwawasi, Arya Afsahi, Ksenia Bezverbnaya, Lisa Newhook, Danielle L. Hayes, Craig Aarts, Bojana Bojovic, Galina F. Denisova, Jacek M. Kwiecien, Ian Brain, Heather Derocher, Katy Milne, Brad H. Nelson, Jonathan L. Bramson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Chimeric antigen receptors (CARs) are effective tools for directing T cell killing of tumors, but may cause adverse side effects. Here the authors show that coupling of antigen-recognition and CD3-binding in a modular format induces more efficient an
Externí odkaz:
https://doaj.org/article/e6ef202d9e6344acbce6ee90ed3c483d
Autor:
Jessica N. McAlpine, Brad H. Nelson, Michael S. Anglesio, C. Blake Gilks, Katy Milne, Samuel Leung, Pascal Schmidt, Heather Derocher, Aline Talhouk
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e245c0fd5fdaad89bcbebbb777acfc
https://doi.org/10.1158/1078-0432.22474023.v1
https://doi.org/10.1158/1078-0432.22474023.v1
Purpose: CD103 is expressed in several immune cell types but in the context of the intratumoral immune response may be most important as a marker of antigen-activated CD8 T cells.Methods: We have examined the prognostic significance of CD103 TILs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7111b091fe44bc00a88ce5a32aaa57da
https://doi.org/10.1158/1078-0432.c.6526716
https://doi.org/10.1158/1078-0432.c.6526716
Supplemental Table 1. A report concerning the source of the biospecimen and data using the BRISQ guidelines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1048b02fe838e415c524a3720f29ae8
https://doi.org/10.1158/1078-0432.22467699
https://doi.org/10.1158/1078-0432.22467699
Supplemental Figure 2: Prognostic impact of CD103 and CD8 alone and combination in the Basel-like subset of breast cancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e123fe30899a07f8d3cbb8c18ddbb591
https://doi.org/10.1158/1078-0432.22467702.v1
https://doi.org/10.1158/1078-0432.22467702.v1
Supplemental Table 2. Association of CD103 TIL and other markers of intra-tumoral immune response.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b105b70d34054a070365884d8957210
https://doi.org/10.1158/1078-0432.22467696
https://doi.org/10.1158/1078-0432.22467696
Supplemental Table 4. Univariate and multivariate analyses of clinical parameters and eCD103 or eCD8 status and their relation with recurrence free survival and overall survival in all cases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09badefc41e3d1e0ca88e86cef2c8898
https://doi.org/10.1158/1078-0432.22467690.v1
https://doi.org/10.1158/1078-0432.22467690.v1
Autor:
Jessica N. McAlpine, Brad H. Nelson, Michael S. Anglesio, C. Blake Gilks, Katy Milne, Samuel Leung, Pascal Schmidt, Heather Derocher, Aline Talhouk
Supplementary Tables S1-S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33992e658ae89ff617f4ee1a3ddc148b
https://doi.org/10.1158/1078-0432.22474020
https://doi.org/10.1158/1078-0432.22474020
Autor:
Jessica N. McAlpine, Brad H. Nelson, Michael S. Anglesio, C. Blake Gilks, Katy Milne, Samuel Leung, Pascal Schmidt, Heather Derocher, Aline Talhouk
Purpose:Tumors with high mutation load are thought to engender stronger immune responses, which in turn promote prolonged patient survival. To investigate this, we assessed tumor-infiltrating lymphocytes (TILs) and immunosuppressive factors across th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6a971eb78a09f43136fddf30a87620
https://doi.org/10.1158/1078-0432.c.6528657.v1
https://doi.org/10.1158/1078-0432.c.6528657.v1