Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Heather D. Snell"'
Autor:
Zhicheng Zuo, Rachel N. Smith, Zhenglan Chen, Amruta S. Agharkar, Heather D. Snell, Renqi Huang, Jin Liu, Eric B. Gonzales
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Acid-sensing ion channels (ASICs) sense changes in extracellular acidity with Ca2+ as an allosteric modulator and channel blocker. Here authors use electrophysiology and molecular dynamics simulation to identify the residue in ASIC3 which modulates p
Externí odkaz:
https://doaj.org/article/13f55aaea8244e21bacd420c63712ecc
Autor:
Heather D. Snell, Ariel Vitenzon, Esra Tara, Chris Chen, Jaafar Tindi, Bryen A. Jordan, Kamran Khodakhah
Publikováno v:
Science advances. 8(16)
Stress is the most common trigger among episodic neurologic disorders. In episodic ataxia type 2 (EA2), physical or emotional stress causes episodes of severe motor dysfunction that manifest as ataxia and dystonia. We used the tottering (tg/tg) mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d677c0f078607a5caa2236b0d6bf4fc
https://pubmed.ncbi.nlm.nih.gov/35672171
https://pubmed.ncbi.nlm.nih.gov/35672171
Autor:
Heather D. Snell, Amruta S. Agharkar, Jin Liu, Rachel N. Smith, Eric B. Gonzales, Ren-Qi Huang, Zhicheng Zuo, Zhenglan Chen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Acid-sensing ion channels (ASICs) evolved to sense changes in extracellular acidity with the divalent cation calcium (Ca2+) as an allosteric modulator and channel blocker. The channel-blocking activity is most apparent in ASIC3, as removing Ca2+ resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098157cba71abb0e4b115a9a7adfe7eb
http://link.springer.com/article/10.1038/s41467-018-04424-0
http://link.springer.com/article/10.1038/s41467-018-04424-0
Autor:
Heather D. Snell, Eric B. Gonzales
Publikováno v:
Channels. 10:498-506
Guanidine compounds act as ion channel modulators. In the case of Cys-loop receptors, the guanidine compound amiloride antagonized the heteromeric GABA-A, glycine, and nicotinic acetylcholine receptors. However, amiloride exhibits characteristics con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3b6c7fe1722087ce25b7ca123ea229
https://doi.org/10.1080/19336950.2016.1207021
https://doi.org/10.1080/19336950.2016.1207021
Autor:
Zhicheng, Zuo, Rachel N, Smith, Zhenglan, Chen, Amruta S, Agharkar, Heather D, Snell, Renqi, Huang, Jin, Liu, Eric B, Gonzales
Publikováno v:
Nature Communications
Acid-sensing ion channels (ASICs) evolved to sense changes in extracellular acidity with the divalent cation calcium (Ca2+) as an allosteric modulator and channel blocker. The channel-blocking activity is most apparent in ASIC3, as removing Ca2+ resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5dd72d3c8deec80985d413a0d6c1f9e9
https://pubmed.ncbi.nlm.nih.gov/29802295
https://pubmed.ncbi.nlm.nih.gov/29802295
Autor:
Eric B. Gonzales, Heather D. Snell
Amiloride, a diuretic used in the treatment of hypertension and congestive heart failure, and 2-guanidine-4-methylquinazoline (GMQ) are guanidine compounds that modulate acid-sensing ion channels. Both compounds have demonstrated affinity for a varie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f435015cbf2bb81e855c65bdc63b1ed3
https://europepmc.org/articles/PMC4429676/
https://europepmc.org/articles/PMC4429676/
Autor:
Eric B. Gonzales, Heather D. Snell
Publikováno v:
The FASEB Journal. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac93a7f62a4c44a08bbfd6ee8c90d444
https://doi.org/10.1096/fasebj.28.1_supplement.1059.3
https://doi.org/10.1096/fasebj.28.1_supplement.1059.3