Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Heather D. Maynard"'
Publikováno v:
Data in Brief, Vol 8, Iss , Pp 506-515 (2016)
We present here the calculation of the mean time to capture of a tethered ligand to the receptor. This calculation is then used to determine the shift in the partitioning between (1) free, (2) singly bound, and (3) doubly bound ligands in chemical eq
Externí odkaz:
https://doaj.org/article/ac51377005434eb5bb2b465a79376fe7
Publikováno v:
ACS Bio & Med Chem Au. 3:189-200
Autor:
Hayden R. Montgomery, Marco S. Messina, Evan A. Doud, Alexander M. Spokoyny, Heather D. Maynard
Publikováno v:
Bioconjugate Chemistry. 33:1536-1542
Autor:
Hayden R, Montgomery, Marco S, Messina, Evan A, Doud, Alexander M, Spokoyny, Heather D, Maynard
Publikováno v:
Bioconjug Chem
Bioconjugation techniques for biomolecule-polymer conjugation are numerous, however, slow kinetics and steric challenges generally necessitate excess reagents or long reactions times. Organometallic transformations are known to circumvent these issue
Autor:
Jeong Hoon Ko, Neil L. Forsythe, Madeline B. Gelb, Kathryn M. M. Messina, Uland Y. Lau, Arvind Bhattacharya, Tove Olafsen, Jason T. Lee, Kathleen A. Kelly, Heather D. Maynard
Publikováno v:
Biomacromolecules. 23:3383-3395
Poly(styrenyl acetal trehalose) (pSAT), composed of trehalose side chains linked to a polystyrene backbone via acetals, stabilizes a variety of proteins and enzymes against fluctuations in temperature. A promising application of pSAT is conjugation o
Autor:
Madeline B. Gelb, Kathryn M. M. Messina, Daniele Vinciguerra, Jeong Hoon Ko, Jeffrey Collins, Mikayla Tamboline, Shili Xu, F. Javier Ibarrondo, Heather D. Maynard
Publikováno v:
ACS applied materialsinterfaces. 14(33)
Insulin, the oldest U.S. Food and Drug Administration (FDA)-approved recombinant protein and a World Health Organization (WHO) essential medicine for treating diabetes globally, faces challenges due to its storage instability. One approach to stabili
Autor:
Neil L. Forsythe, Mikayla F. Tan, Daniele Vinciguerra, Jacquelin Woodford, Adam Z. Stieg, Heather D. Maynard
Publikováno v:
Macromolecules, vol 55, iss 22
Enzyme nanogels (ENGs) offer a convenient method to protect therapeutic proteins from in vivo stressors. Current methodologies to prepare ENGs rely on either covalent modification of surface residues or the noncovalent assembly of monomers at the pro
Autor:
Douglas A. Rose, Kathleen K. Chen, Priera H. Panescu, Glareh Natalie Kashanchi, Heather D. Maynard
Publikováno v:
ACS Sustainable Chemistry & Engineering. 9:5776-5782
Proherbicides increase the utilization efficiency of herbicides by reducing their off-site movement and premature degradation. Mesotrione is a prevalent herbicide used to control weeds in maize cro...
Autor:
Heather D. Maynard, Neil L. Forsythe
Publikováno v:
Polym Chem
Antibodies and antigen binding fragments (FABs) are widely used as therapeutics and conjugated polymers can enhance the properties of these important biomolecules. However, limitations to the selectivity and stability of current conjugation methodolo
Autor:
Douglas A. Rose, Joseph W. Treacy, Zhongyue J. Yang, Jeong Hoon Ko, K. N. Houk, Heather D. Maynard
Publikováno v:
Journal of the American Chemical Society. 144(13)
Traceless self-immolative linkers are widely used for the reversible modification of proteins and peptides. This article describes a new class of traceless linkers based on