Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Heather D. Burleigh-Flayer"'
Autor:
Robert W. Kapp, Gary A. Wright, Jonathan Hurley, Heather D. Burleigh-Flayer, Christopher Bevan, Michael W. Gill, T. H. Gardiner, T. R. Tyler
Publikováno v:
Journal of Applied Toxicology. 18:373-381
In a previous subchronic neurotoxicity study, increases in motor activity were observed for female rats after 9 and 13 weeks of exposure to 5000 ppm of isopropanol vapor. The present study was conducted to evaluate the reproducibility of these effect
Publikováno v:
Toxic Substance Mechanisms. 16:371-383
Bis\[2-(dimethylamino)ethyl] ether (DMAEE; CAS no. 3033-62-3) is an industrial chemical with a potential for vapor exposure. The absorption, tissue distribution, and elimination of 14C-DMAEE were i...
Publikováno v:
Toxicology and Industrial Health. 11:489-501
Overexposure to glutaraldehyde (GA) vapor (CAS No. 111-30-8) is known to cause peripheral sensory irritant effects in humans. Respiratory sensory irritation was investigated in male ND4 Swiss Webster mice to quantify the effect, and also as a prelimi
Autor:
HEATHER D. BURLEIGH-FLAYER, MICHAEL W. GILL, DALE E. STROTHER, LAWRENCE W. MASTEN, RICHARD H. MCKEE, TIPTON R. TYLER, THOMAS GARDINER
Publikováno v:
Toxicological Sciences. 23:421-428
Publikováno v:
Inhalation Toxicology. 5:189-201
Prior aerosol inhalation studies on heavier molecular weight members of this series of ethylene oxide/propylene oxide (EO/PO) polymers have demonstrated that the lung is the primary target organ in rats. These studies extended the toxicological data
Publikováno v:
Toxicology. 124(2)
Medical reports linking asthma and occupational exposure to airborne powder produced during the manufacture of konjac flour have been reported in the literature. This study was conducted to investigate whether exposure to food grade konjac flour, whi
Autor:
Heather D. Burleigh-Flayer, C. Bevan, D. Neptun, R. Kapp, Gary A. Wright, T. R. Tyler, R. Garman, T. H. Gardiner
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 36(2)
The potential oncogenic effects of isopropanol, a widely used solvent, were investigated. Four groups of animals, each consisting of 75 CD-1 mice/sex and 75 Fischer 344 rats/sex, were exposed to isopropanol vapor (CAS No. 67-63-0) at target concentra
Autor:
Edward H. Fowler, Allan W. Ader, Heather D. Burleigh-Flayer, Michelle L. Rybka, Michael S. Werley
Publikováno v:
American Industrial Hygiene Association journal. 57(8)
This study determined the origin of pituitary lesions found in male ND4 Swiss Webster mice following a single head-only exposure to inhaled test materials using ASTM E981-84, standard test method for estimating sensory irritancy of airborne chemicals
Autor:
D. E. Strother, Lawrence W. Masten, Heather D. Burleigh-Flayer, Michael W. Gill, Richard H. McKee, T. H. Gardiner, T. R. Tyler
Publikováno v:
Journal of applied toxicology : JAT. 15(2)
Five groups of 25 Fischer 344 rats of each sex were exposed for 6 h to isopropanol vapor at 0, 500, 1500, 5000 or 10,000 ppm. Behavioral observations for 10 rats of each sex were made prior to and 1, 6, and 24 h after exposure. Motor activity was eva
Autor:
Heather D. Burleigh-Flayer, Michael W. Gill, Richard H. McKee, Lawrence W. Masten, T. R. Tyler, T. H. Gardiner, D. E. Strother
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 23(3)
This study was conducted to evaluate the possible subchronic toxicity as well as neurobehavioral effects of isopropanol, a widely used industrial and commercial solvent. Five groups, each containing 10 Fischer 344 rats/sex and 10 CD-1 mice/sex, were