Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Heather D. Agnew"'
Autor:
Jeré A. Wilson, Heather D. Agnew, Maruthi Kumar Narayanam, Breanna K. Luton, Annabelle L. Cantu, Jennifer M. Murphy, Anders M. Eliasen, Jacquie Malette Loredo, Shili Xu, Malley Nason, Nicole A. LaBerge, Bert T. Lai
Publikováno v:
Bioconjugate Chemistry. 32:2073-2082
Chemically synthesized, small peptides that bind with high affinity and specificity to CD8-expressing (CD8+) tumor-infiltrating T cells, yet retain the desirable characteristics of small molecules, hold valuable potential for diagnostic molecular ima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bf00381c37cd20ed36ea55860dba53f
https://doi.org/10.1021/acs.bioconjchem.1c00379
https://doi.org/10.1021/acs.bioconjchem.1c00379
Publikováno v:
Methods in Molecular Biology ISBN: 9781071616888
The protein catalyzed capture agent (PCC) method is a powerful combinatorial screening strategy for discovering synthetic macrocyclic peptide ligands, called PCCs, to designated protein epitopes. The foundational concept of the PCC method is the use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::311539a1bb65defe7bfcd22ec49dc5bc
https://doi.org/10.1007/978-1-0716-1689-5_10
https://doi.org/10.1007/978-1-0716-1689-5_10
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2371
The protein catalyzed capture agent (PCC) method is a powerful combinatorial screening strategy for discovering synthetic macrocyclic peptide ligands, called PCCs, to designated protein epitopes. The foundational concept of the PCC method is the use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bde1a8a8576dde3e9ebf44f113fb0efd
https://pubmed.ncbi.nlm.nih.gov/34596849
https://pubmed.ncbi.nlm.nih.gov/34596849
Autor:
Amy M McCarthy-Torrens, Bert T. Lai, Matthew B. Coppock, James R. Heath, Carmen M Warren, Heather D. Agnew, Matthew N. Idso, JingXin Liang
Protein-catalyzed capture agents (PCCs) are synthetic and modular peptide-based affinity agents that are developed through the use of single generation in situ click chemistry screens against large peptide libraries. In such screens, the target prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9a82f1f1a22c0296330cb5adf367c5
https://europepmc.org/articles/PMC6731165/
https://europepmc.org/articles/PMC6731165/
Autor:
Blake Farrow, Sung A Hong, Errika C. Romero, Bert Lai, Matthew B. Coppock, Kaycie M. Deyle, Amethist S. Finch, Dimitra N. Stratis-Cullum, Heather D. Agnew, Sung Yang, James R. Heath
Publikováno v:
ACS nano. 12(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c28a2b9886350b54fd1047a8074d48
https://pubmed.ncbi.nlm.nih.gov/24063758
https://pubmed.ncbi.nlm.nih.gov/24063758
Autor:
Jeré A. Wilson, Bert T. Lai, Heather D. Agnew, Jacquie Malette Loredo, James R. Heath, Suresh M. Pitram, Nicole A. LaBerge
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 24(15)
The IL-17 cytokine family is associated with multiple immune and autoimmune diseases and comprises important diagnostic and therapeutic targets. This work reports the development of epitope-targeted ligands designed for differential detection of huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7bf32eb0aa3738ade07e2bcba437119
https://pubmed.ncbi.nlm.nih.gov/29319889
https://pubmed.ncbi.nlm.nih.gov/29319889
Autor:
Heather D. Agnew, Blake Farrow, Sung Yang, Amethist S. Finch, Sung A Hong, Matthew B. Coppock, Errika C. Romero, Bert T. Lai, Kaycie Deyle, Dimitra N. Stratis-Cullum, James R. Heath
Publikováno v:
ACS Nano. 7:9452-9460
We report on a robust and sensitive approach for detecting protective antigen (PA) exotoxin from Bacillus anthracis in complex media. A peptide-based capture agent against PA was developed by improving a bacteria display-developed peptide into a high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0308131639e20d5560c2d7456237db0c
https://doi.org/10.1021/nn404296k
https://doi.org/10.1021/nn404296k
Autor:
Amethist S. Finch, Deborah A. Sarkes, Paul Kearney, Kenneth C. Fang, Candice Warner, Brandi L. Dorsey, Blake Farrow, Jeré A. Wilson, Sherri L. Candelario, Jacquie Malette, Dimitra N. Stratis-Cullum, Heather D. Agnew, Matthew B. Coppock, Bert T. Lai, Joshua A. Orlicki, Suresh M. Pitram, Scott M. Law, James R. Heath, Rosemary D. Rohde
Publikováno v:
Biopolymers
We report on peptide‐based ligands matured through the protein catalyzed capture (PCC) agent method to tailor molecular binders for in vitro sensing/diagnostics and in vivo pharmacokinetics parameters. A vascular endothelial growth factor (VEGF) bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596d7b94e693fdbbab40756f42620370
https://pubmed.ncbi.nlm.nih.gov/27539157
https://pubmed.ncbi.nlm.nih.gov/27539157
Autor:
Suresh M. Pitram, Jaehong Lim, Su Seong Lee, Heather D. Agnew, James R. Heath, Rosemary D. Rohde, Arundhati Nag, Steven W. Millward, Bert T. Lai
Publikováno v:
Integrative Biology. 5:87-95
Advances in the fields of proteomics, molecular imaging, and therapeutics are closely linked to the availability of affinity reagents that selectively recognize their biological targets. Here we present a review of Iterative Peptide In Situ Click Che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26426150c186997c1205b3d4cddbd6d6
https://doi.org/10.1039/c2ib20110k
https://doi.org/10.1039/c2ib20110k
Autor:
K. Barry Sharpless, Heather D. Agnew, Kaycie Deyle, James R. Heath, Jaehong Lim, Arundhati Nag, Su Seong Lee, Ryan K. Henning, Suresh M. Pitram, Steven W. Millward, Jessica A. Pfeilsticker, Gabriel A. Kwong, Jason E. Hein
Publikováno v:
Journal of the American Chemical Society. 133:18280-18288
We describe the use of iterative in situ click chemistry to design an Akt-specific branched peptide triligand that is a drop-in replacement for monoclonal antibodies in multiple biochemical assays. Each peptide module in the branched structure makes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7098a2f01580fc5339b0ae7372ce8f23
https://doi.org/10.1021/ja2064389
https://doi.org/10.1021/ja2064389