Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Heather Currinn"'
Autor:
Lisa A. Stott, Cheryl A. Brighton, Jason Brown, Richard Mould, Kirstie A. Bennett, Robert Newman, Heather Currinn, Flavia Autore, Alicia P. Higueruelo, Benjamin G. Tehan, Cliona MacSweeney, Michael A. O'Brien, Steve P. Watson
Publikováno v:
Heliyon, Vol 7, Iss 6, Pp e07201- (2021)
The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identi
Externí odkaz:
https://doaj.org/article/9ab0b310527d4fceba02192d55edbff1
Autor:
Zita Balklava, Christian Niehage, Heather Currinn, Laura Mellor, Benjamin Guscott, Gino Poulin, Bernard Hoflack, Thomas Wassmer
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130485 (2015)
While the Amyloid Precursor Protein (APP) plays a central role in Alzheimer's disease, its cellular function still remains largely unclear. It was our goal to establish APP function which will provide insights into APP's implication in Alzheimer's di
Externí odkaz:
https://doaj.org/article/37a975215e6641dea43cf0d7be01a434
Autor:
Robert Newman, Benjamin G. Tehan, J.D. Brown, Richard Mould, Alicia P. Higueruelo, K.A. Bennett, O'brien Michael Alistair, Flavia Autore, Cliona MacSweeney, Heather Currinn, Cheryl A. Brighton, Lisa A. Stott, Steve P. Watson
Publikováno v:
Heliyon
Heliyon, Vol 7, Iss 6, Pp e07201-(2021)
Heliyon, Vol 7, Iss 6, Pp e07201-(2021)
The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e712b64596b5eaa25e6dd34e58553b
https://pubmed.ncbi.nlm.nih.gov/34189291
https://pubmed.ncbi.nlm.nih.gov/34189291
Autor:
Elisabeth O’Flaherty, Heather Currinn, Anthony P. Davenport, Duuamene Nyimanu, J.D. Brown, Alastair J. H. Brown, Thomas Williams, Janet J. Maguire, Gregory Strachan, Robyn Macrae
Publikováno v:
Basic Science.
Introduction Fluorescent ligands are a promising tool in the study of GPCR pharmacology as they are safe and more cost effective than conventional probes such as radioligands. In this study, we investigated the use of a novel fluorescent ligand, apel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c52652e79799e0cac1ae89bb1ba4504
https://doi.org/10.1136/heartjnl-2019-bcs.179
https://doi.org/10.1136/heartjnl-2019-bcs.179
Autor:
Janet J. Maguire, Rhoda E. Kuc, Stefan Gräf, Thomas Williams, Heather Currinn, Elisabeth O’Flaherty, Gregory Strachan, Anthony P. Davenport, Alastair J. H. Brown, J.D. Brown, Robyn Macrae, Duuamene Nyimanu, Nicholas W. Morrell
Publikováno v:
Basic Science.
Introduction The apelin receptor is a class A GPCR that binds two endogenous peptide ligands, apelin and elabela/toddler, to regulate the cardiovascular system. Apelin peptide levels are downregulated in pulmonary arterial hypertension (PAH) but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6517cb57db79e91056a29b15e5006d22
https://doi.org/10.1136/heartjnl-2019-bcs.207
https://doi.org/10.1136/heartjnl-2019-bcs.207
Autor:
Thomas Wassmer, Heather Currinn
Phosphoinositides are important components of eukaryotic membranes that are required for multiple forms of membrane dynamics. Phosphoinositides are involved in defining membrane identity, mediate cell signalling and control membrane trafficking event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fefe0eb866585f1cd123dab9f376fa
https://publications.aston.ac.uk/id/eprint/27808/1/Amyloid_Precursor.pdf
https://publications.aston.ac.uk/id/eprint/27808/1/Amyloid_Precursor.pdf
Autor:
David E. Whitworth, Alan Cookson, Heather Currinn, Hazel M. Davey, Gillian Cooke-Fox, Alun Evans, Paulina J Stanczyk
Publikováno v:
Microbiology. 158:2742-2752
The deltaproteobacterium Myxococcus xanthus predates upon members of the soil microbial community by secreting digestive factors and lysing prey cells. Like other Gram-negative bacteria, M. xanthus produces outer membrane vesicles (OMVs), and we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0a947d5e4636a634a37999e99dcd47
https://doi.org/10.1099/mic.0.060343-0
https://doi.org/10.1099/mic.0.060343-0
Autor:
Heather Currinn, Laura E. Mellor, Benjamin Guscott, Bernard Hoflack, Christian Niehage, Zita Balklava, Gino B. Poulin, Thomas Wassmer
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130485 (2015)
PLoS ONE
PLoS ONE
While the Amyloid Precursor Protein (APP) plays a central role in Alzheimer's disease, its cellular function still remains largely unclear. It was our goal to establish APP function which will provide insights into APP's implication in Alzheimer's di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6328697aa47810cef02fcf32897ba8d
https://publications.aston.ac.uk/id/eprint/26188/1/Amyloid_precursor_protein_controls_PIKfyve_function.pdf
https://publications.aston.ac.uk/id/eprint/26188/1/Amyloid_precursor_protein_controls_PIKfyve_function.pdf
Autor:
Shirin Meher Pocha, Ya-Huei Lin, Elisabeth Knust, Thomas Wassmer, Alice Rothnie, Heather Currinn
Publikováno v:
Journal of cell science. 128(24)
Maintenance of epithelial polarity depends on the correct localization and levels of polarity determinants. The evolutionarily conserved transmembrane protein Crumbs is crucial for the size and identity of the apical membrane, yet little is known abo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586c6be0f7f0dd377a7c7848bb116d47
https://pubmed.ncbi.nlm.nih.gov/26527400
https://pubmed.ncbi.nlm.nih.gov/26527400
Publikováno v:
Cellular and Molecular Life Sciences
Phosphoinositides are signalling lipids that are crucial for major signalling events as well as established regulators of membrane trafficking. Control of endosomal sorting and endosomal homeostasis requires phosphatidylinositol-3-phosphate (PI(3)P)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2bf8eed386015bcbfbbdaf2438eb41