Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Heather Coker"'
Autor:
Joseph S. Bowness, Tatyana B. Nesterova, Guifeng Wei, Lisa Rodermund, Mafalda Almeida, Heather Coker, Emma J. Carter, Artun Kadaster, Neil Brockdorff
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110830- (2022)
Summary: X chromosome inactivation (XCI) is mediated by the non-coding RNA Xist, which directs chromatin modification and gene silencing in cis. The RNA binding protein SPEN and associated corepressors have a central role in Xist-mediated gene silenc
Externí odkaz:
https://doaj.org/article/cbb4ebeca8874aee9b97248ef77766d9
Autor:
Tatyana B. Nesterova, Guifeng Wei, Heather Coker, Greta Pintacuda, Joseph S. Bowness, Tianyi Zhang, Mafalda Almeida, Bianca Bloechl, Benoit Moindrot, Emma J. Carter, Ines Alvarez Rodrigo, Qi Pan, Ying Bi, Chun-Xiao Song, Neil Brockdorff
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Xist RNA is the master regulator of X chromosome inactivation. Here the authors describe a systematic analysis of Xist-mediated allelic silencing in mouse ESC models and define the contribution of different pathways that regulate gene silencing.
Externí odkaz:
https://doaj.org/article/1099fcaec9864035a2a87b2701f1ba55
Autor:
Heather Coker, Guifeng Wei, Benoit Moindrot, Shabaz Mohammed, Tatyana Nesterova, Neil Brockdorff
Publikováno v:
Wellcome Open Research, Vol 5 (2020)
Background: X chromosome inactivation in mammals is regulated by the non-coding (nc) RNA, Xist, which represses the chromosome from which it is transcribed. High levels of the N6-methyladenosine (m6A) RNA modification occur within Xist exon I, close
Externí odkaz:
https://doaj.org/article/b298b9adf43348348402ac34948230ba
Autor:
Benoit Moindrot, Andrea Cerase, Heather Coker, Osamu Masui, Anne Grijzenhout, Greta Pintacuda, Lothar Schermelleh, Tatyana B. Nesterova, Neil Brockdorff
Publikováno v:
Cell Reports, Vol 12, Iss 4, Pp 562-572 (2015)
X-chromosome inactivation is the process that evolved in mammals to equalize levels of X-linked gene expression in XX females relative to XY males. Silencing of a single X chromosome in female cells is mediated by the non-coding RNA Xist. Although pr
Externí odkaz:
https://doaj.org/article/1128f7ecf32f4264b63b383ff7c04811
Autor:
Mafalda Almeida, Joseph S Bowness, Jernej Ule, Greta Pintacuda, Heather Coker, Neil Brockdorff, Guifeng Wei
RNA N6-methyladenosine (m6A) modification plays important roles in multiple aspects of RNA regulation. m6A is installed cotranscriptionally by the METTL3/14 complex, but its direct roles in RNA processing remain unclear. Here, we investigate the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7411d4e30b73e82fcd08dce1b5537e
https://ora.ox.ac.uk/objects/uuid:82b04333-1c12-4f8c-beba-8c668299f843
https://ora.ox.ac.uk/objects/uuid:82b04333-1c12-4f8c-beba-8c668299f843
Autor:
Neil Brockdorff, Lothar Schermelleh, Bramman Rajkumar, Tatyana B. Nesterova, David Miguel Susano Pinto, Joseph S Bowness, Heather Coker, Lisa Rodermund, Roel Oldenkamp, Guifeng Wei
Xist RNA directs the process of X-chromosome inactivation in mammals by spreading in cis along the chromosome from which it is transcribed and recruiting chromatin modifiers to silence gene transcription. To elucidate mechanisms of Xist RNA cis-confi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1bc22dac2f2f6e5ff29d80a69174fd6
https://doi.org/10.1101/2020.11.24.396473
https://doi.org/10.1101/2020.11.24.396473
Autor:
Neil Brockdorff, Jernej Ule, Guifeng Wei, Mafalda Almeida, Joseph S Bowness, Greta Pintacuda, Heather Coker
RNAN6-methyladenosine (m6A) modification plays important roles in multiple aspects of RNA regulation. m6A is installed co-transcriptionally by the METTL3/14 complex, but its direct roles in RNA processing remain unclear. Here we investigate the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71d933e9330d5d799851bf06d3d04226
https://doi.org/10.1101/2020.09.10.291179
https://doi.org/10.1101/2020.09.10.291179
Autor:
Guifeng, Wei, Mafalda, Almeida, Greta, Pintacuda, Heather, Coker, Joseph S, Bowness, Jernej, Ule, Neil, Brockdorff
Publikováno v:
Genome Res
RNA N(6)-methyladenosine (m(6)A) modification plays important roles in multiple aspects of RNA regulation. m(6)A is installed cotranscriptionally by the METTL3/14 complex, but its direct roles in RNA processing remain unclear. Here, we investigate th
Autor:
Neil Brockdorff, Heather Coker, Shabaz Mohammed, Tatyana B. Nesterova, Guifeng Wei, Benoit Moindrot
Publikováno v:
Wellcome Open Research
Wellcome Open Research, 2020, 5, pp.31. ⟨10.12688/wellcomeopenres.15711.1⟩
Wellcome Open Research, 2020, 5, pp.31. ⟨10.12688/wellcomeopenres.15711.1⟩
Background: X chromosome inactivation in mammals is regulated by the non-coding (nc) RNA, Xist, which represses the chromosome from which it is transcribed. High levels of the N6-methyladenosine (m6A) RNA modification occur within Xist exon I, close
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1086bd25903be197c3b9fd3458d44573
https://hal.science/hal-02542671
https://hal.science/hal-02542671
The biology of non-coding RNA (ncRNA) and the regulation of mammalian gene expression is a rapidly expanding field. In this review, we consider how recent advances in technology, enabling the precise mapping of modifications to RNA transcripts, has p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e60f9d155ce660186baf4a08730b6d
https://doi.org/10.1016/j.bbagrm.2018.12.002
https://doi.org/10.1016/j.bbagrm.2018.12.002