Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Heather C. O′Farrell"'
Autor:
Jason P. Rife, Lei Wang, Gordon L. Archer, Heather C. O'Farrell, Martin K. Safo, Sam Boundy, Faik N. Musayev
Publikováno v:
Journal of Biological Chemistry. 288:132-140
The gene orfX is conserved among all staphylococci, and its complete sequence is maintained upon insertion of the staphylococcal chromosome cassette mec (SCCmec) genomic island, containing the gene encoding resistance to β-lactam antibiotics (mecA),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303650e3d0dc85d26a3eb622b2ca05aa
https://doi.org/10.1074/jbc.m112.385138
https://doi.org/10.1074/jbc.m112.385138
Autor:
Zhili Xu, Leah A. Pogorzala, Faik N. Musayev, Nagesh Pulicherla, Gloria M. Culver, Jason P. Rife, Heather C. O′Farrell, J. Neel Scarsdale, Elaine A. Sia
Publikováno v:
Journal of Molecular Biology. 391:884-893
The enzymes of the KsgA/Dim1 family are universally distributed throughout all phylogeny; however, structural and functional differences are known to exist. The well-characterized function of these enzymes is to dimethylate two adjacent adenosines of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714a0e8cae2793f4962d626824d417c0
https://doi.org/10.1016/j.jmb.2009.06.015
https://doi.org/10.1016/j.jmb.2009.06.015
Publikováno v:
RNA. 12:725-733
Ribosome biogenesis is a complicated process, involving numerous cleavage, base modification and assembly steps. All ribosomes share the same general architecture, with small and large subunits made up of roughly similar rRNA species and a variety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01de7e2fe2ed35316ba0f8df69b0596
https://doi.org/10.1261/rna.2310406
https://doi.org/10.1261/rna.2310406
Publikováno v:
Journal of Biological Chemistry
The Journal of biological chemistry
The Journal of biological chemistry
The assembly of the ribosomal subunits is facilitated by ribosome biogenesis factors. The universally conserved methyltransferase KsgA modifies two adjacent adenosine residues in the 3'-terminal helix 45 of the 16 S ribosomal RNA (rRNA). KsgA recogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db01ea62678e11b317b1a6b7c8616a9b
Publikováno v:
Biochemistry. 51(1)
The KsgA methyltransferase is universally conserved and plays a key role in regulating ribosome biogenesis. KsgA has a complex reaction mechanism, transferring a total of four methyl groups onto two separate adenosine residues, A1518 and A1519, in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b68e612fb0383984ea1ef60aff22ea
https://pubmed.ncbi.nlm.nih.gov/22142337
https://pubmed.ncbi.nlm.nih.gov/22142337
Publikováno v:
Biochemistry. 49(12)
The KsgA/Dim1 family of proteins is intimately involved in ribosome biogenesis in all organisms. These enzymes share the common function of dimethylating two adenosine residues near the 3'-OH end of the small subunit rRNA; orthologs in the three king
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fa310d573517f7cdb9b7f541ea84fc
https://pubmed.ncbi.nlm.nih.gov/20163168
https://pubmed.ncbi.nlm.nih.gov/20163168
Publikováno v:
Nature structuralmolecular biology. 15(5)
In contrast to the diversity of most ribosomal RNA modification patterns and systems, the KsgA methyltransferase family seems to be nearly universally conserved along with the modifications it catalyzes. Our data reveal that KsgA interacts with small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfe4356811faef7caa44455e7994fad
https://pubmed.ncbi.nlm.nih.gov/18391965
https://pubmed.ncbi.nlm.nih.gov/18391965
Publikováno v:
Journal of molecular biology. 339(2)
The bacterial enzyme KsgA catalyzes the transfer of a total of four methyl groups from S-adenosyl- l -methionine (S-AdoMet) to two adjacent adenosine bases in 16 S rRNA. This enzyme and the resulting modified adenosine bases appear to be conserved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b76d9ac99bd187baf6d4497ebef658
https://pubmed.ncbi.nlm.nih.gov/15136037
https://pubmed.ncbi.nlm.nih.gov/15136037
Autor:
Jason P. Rife, Heather C. O'Farrell
Publikováno v:
BMC Microbiology, Vol 12, Iss 1, p 244 (2012)
BMC Microbiology
BMC Microbiology
Background The KsgA methyltransferase has been conserved throughout evolution, methylating two adenosines in the small subunit rRNA in all three domains of life as well as in eukaryotic organelles that contain ribosomes. Understanding of KsgA’s imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2deee0bffeddc7d001c2d5132081fe5b
https://doi.org/10.1186/1471-2180-12-244
https://doi.org/10.1186/1471-2180-12-244
Publikováno v:
BMC Research Notes
BMC Research Notes, Vol 1, Iss 1, p 108 (2008)
BMC Research Notes, Vol 1, Iss 1, p 108 (2008)
Background One of the 60 or so genes conserved in all domains of life is the ksgA/dim1 orthologous group. Enzymes from this family perform the same post-transcriptional nucleotide modification in ribosome biogenesis, irrespective of organism. Despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe9a87ce94d132401df7175ee825b7c