Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Heather C, Rice"'
Autor:
Jessica D. Hense, Driele N. Garcia, Bianka M. Zanini, Mariana M. Barreto, Giulia C. Perreira, José V. V. Isola, Camila de Brito, Michal Fornalik, Samim A. Mondal, Bianca M. Ávila, Thais L. Oliveira, Heather C. Rice, Charles I. Lacy, Rodrigo A. Vaucher, Jeffrey B. Mason, Michal M. Masternak, Michael B. Stout, Augusto Schneider
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Senescent cells have been linked to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the effectiveness of senolytic drugs in reducing liver damage in mice with MASLD is not clear. Additionally, M
Externí odkaz:
https://doaj.org/article/326ef71c5c2c449693e78d894c2773a5
Autor:
Hongyang Xu, Shylesh Bhaskaran, Katarzyna M. Piekarz, Rojina Ranjit, Jan Bian, Parker Kneis, Aubrey Ellis, Suyesha Bhandari, Heather C. Rice, Holly Van Remmen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Emerging evidence suggests that patients with Alzheimer’s disease (AD) may show accelerated sarcopenia phenotypes. To investigate whether pathological changes associated with neuronal death and cognitive dysfunction also occur in peripheral motor n
Externí odkaz:
https://doaj.org/article/33029d926d524910bcfb714ac428edef
Autor:
Heather C. Rice, Gabriele Marcassa, Iordana Chrysidou, Katrien Horré, Tracy L. Young-Pearse, Ulrike C. Müller, Takashi Saito, Takaomi C. Saido, Robert Vassar, Joris de Wit, Bart De Strooper
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-8 (2020)
Abstract The amyloid-β (Aβ) peptide, the primary constituent of amyloid plaques found in Alzheimer’s disease (AD) brains, is derived from sequential proteolytic processing of the Amyloid Precursor Protein (APP). However, the contribution of diffe
Externí odkaz:
https://doaj.org/article/5d37cdfea3af48149a9c42e6eadd3cbc
Autor:
Yingjun Ding, Junxiong Chen, Shuping Li, Jonathan D. Wren, Akhilesh K. Bajpai, Jie Wang, Takemi Tanaka, Heather C. Rice, Franklin A. Hays, Lu Lu, Xin A. Zhang
Publikováno v:
Oncogene. 42:861-868
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d78b47b344f9c9aa258307d38946eb2
https://doi.org/10.1038/s41388-023-02623-8
https://doi.org/10.1038/s41388-023-02623-8
Autor:
Christina R. Muratore, Constance Zhou, Meichen Liao, Marty A. Fernandez, Walter M. Taylor, Valentina N. Lagomarsino, Richard V. Pearse, II, Heather C. Rice, Joseph M. Negri, Amy He, Priya Srikanth, Dana G. Callahan, Taehwan Shin, Monica Zhou, David A. Bennett, Scott Noggle, J. Christopher Love, Dennis J. Selkoe, Tracy L. Young-Pearse
Publikováno v:
Stem Cell Reports, Vol 9, Iss 6, Pp 1868-1884 (2017)
Summary: Alzheimer's disease (AD) induces memory and cognitive impairment in the absence of motor and sensory deficits during its early and middle course. A major unresolved question is the basis for this selective neuronal vulnerability. Aβ, whic
Externí odkaz:
https://doaj.org/article/9f03abb62b1343ab8aa8f519af659d78
Autor:
Sreemathi Logan, Matthew P Baier, Daniel B Owen, John Peasari, Kenneth L Jones, Rojina Ranjit, Hannah P Yarbrough, Anthony M Masingale, Suyesha Bhandari, Heather C Rice, Michael T Kinter, William E Sonntag
Publikováno v:
PNAS Nexus. 2
The greatest risk factor for cognitive decline is aging. The biological mechanisms for this decline remain enigmatic due, in part, to the confounding of normal aging mechanisms and those that contribute to cognitive impairment. Importantly, many indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b17b8e3126b5e758046e96aada549a71
https://doi.org/10.1093/pnasnexus/pgad101
https://doi.org/10.1093/pnasnexus/pgad101
Autor:
Collyn M. Kellogg, Kevin Pham, Adeline H. Machalinski, Hunter L. Porter, Harris E. Blankenship, Michael B. Stout, Heather C. Rice, Amanda L. Sharpe, Michael J. Beckstead, Ana J. Chucair-Elliott, Sarah R. Ocañas, Willard M. Freeman
Publikováno v:
bioRxiv
Major Histocompatibility Complex I (MHC-I) function in the CNS is still being determined after previously being thought to be absent from the brain. MHC-I expression increases with brain aging in mouse, rat, and human whole tissue analyses. Neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a42275d549dfe469c0587a115227cb2
https://doi.org/10.1101/2023.03.07.531435
https://doi.org/10.1101/2023.03.07.531435
Hypothalamic melanocortin-4 receptors on astrocytes mediate inflammation and body weight homeostasis
Autor:
Nicole L. Eliason, Kevin Pham, Rohan Varshney, Jacob W. Farriester, Charles I. Lacy, Heather C. Rice, Michael C. Rudolph, Willard Freeman, Amanda L. Sharpe
World-wide, nearly 40% of the adult population is classified as clinically obese. Central inflammation is highly correlated with obesity and increases morbidity and deterioration of health. The hypothalamus is a brain region that governs many facets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02e6b3bdfca69d78a9364caf8268b400
https://doi.org/10.1101/2022.12.01.518727
https://doi.org/10.1101/2022.12.01.518727
Autor:
Takaomi C. Saido, Joris de Wit, Robert Vassar, Tracy L. Young-Pearse, Bart De Strooper, Iordana Chrysidou, Katrien Horré, Takashi Saito, Heather C. Rice, Gabriele Marcassa, Ulrike Müller
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-8 (2020)
Molecular Neurodegeneration
Molecular Neurodegeneration
The amyloid-β (Aβ) peptide, the primary constituent of amyloid plaques found in Alzheimer's disease (AD) brains, is derived from sequential proteolytic processing of the Amyloid Precursor Protein (APP). However, the contribution of different cell t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f279e07ae3e08abc05ec594ab4575521
https://doaj.org/article/5d37cdfea3af48149a9c42e6eadd3cbc
https://doaj.org/article/5d37cdfea3af48149a9c42e6eadd3cbc
Autor:
Alessia Soldano, Bart De Strooper, Bassem A. Hassan, Lee G. Fradkin, Lydie Boussicault, Heather C. Rice, Marie-Claude Potier, Iveta M. Petrova, Annelies Claeys, Tengyuan Liu, Maya Nicolas, Tingting Zhang
Publikováno v:
eLife
eLife, 2021, 10, ⟨10.7554/elife.69199⟩
eLife, Vol 10 (2021)
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/elife.69199⟩
eLife, 2021, 10, ⟨10.7554/elife.69199⟩
eLife, Vol 10 (2021)
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/elife.69199⟩
The Amyloid Precursor Protein (APP) and its homologues are transmembrane proteins required for various aspects of neuronal development and activity, whose molecular function is unknown. Specifically, it is unclear whether APP acts as a receptor, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2607970a9e12f41e0201b3bf144f6cf0
https://doi.org/10.7554/elife.69199
https://doi.org/10.7554/elife.69199