Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Heather Burks"'
Autor:
Saskia M. Brachmann, Simona Cotesta, Anna F. Farago, Frederic Zecri, Kun Xu, Rainer Wilcken, Toni Widmer, Peter Wessels, Hans Voshol, Andrea Vaupel, Rowan Stringer, Toshio Shimizu, Richard Sedrani, Christian Schnell, Danielle Roman, Pascal Rigollier, Johannes Ottl, Nils Ostermann, Helen Oakman, Jason Murphy, Sauveur-Michel Maira, Catherine Leblanc, Jeffrey D. Kearns, Eloísa Jiménez Núñez, Ashley Jaeger, Victoria Head, Daniel Alexander Guthy, Marc Gerspacher, Carmine Fedele, Lekshmi Dharmarajan, Ruben de Kanter, Xiaoming Cui, Xueying Chen, Heather Burks, Claudio Bomio-Confaglia, Kim S. Beyer, Louise Barys, Edwige Lorthiois, Andreas Weiss
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d58af020ff3289026b12e3df1b9a0f4
https://doi.org/10.1158/2159-8290.22541471.v1
https://doi.org/10.1158/2159-8290.22541471.v1
Autor:
Saskia M. Brachmann, Simona Cotesta, Anna F. Farago, Frederic Zecri, Kun Xu, Rainer Wilcken, Toni Widmer, Peter Wessels, Hans Voshol, Andrea Vaupel, Rowan Stringer, Toshio Shimizu, Richard Sedrani, Christian Schnell, Danielle Roman, Pascal Rigollier, Johannes Ottl, Nils Ostermann, Helen Oakman, Jason Murphy, Sauveur-Michel Maira, Catherine Leblanc, Jeffrey D. Kearns, Eloísa Jiménez Núñez, Ashley Jaeger, Victoria Head, Daniel Alexander Guthy, Marc Gerspacher, Carmine Fedele, Lekshmi Dharmarajan, Ruben de Kanter, Xiaoming Cui, Xueying Chen, Heather Burks, Claudio Bomio-Confaglia, Kim S. Beyer, Louise Barys, Edwige Lorthiois, Andreas Weiss
Covalent inhibitors of KRASG12C have shown antitumor activity against advanced/metastatic KRASG12C-mutated cancers, though resistance emerges and additional strategies are needed to improve outcomes. JDQ443 is a structurally unique covalent inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090908cffff39039ae33828ed26022f4
https://doi.org/10.1158/2159-8290.c.6549647
https://doi.org/10.1158/2159-8290.c.6549647
Autor:
Andreas Weiss, Edwige Lorthiois, Louise Barys, Kim S. Beyer, Claudio Bomio-Confaglia, Heather Burks, Xueying Chen, Xiaoming Cui, Ruben de Kanter, Lekshmi Dharmarajan, Carmine Fedele, Marc Gerspacher, Daniel Alexander Guthy, Victoria Head, Ashley Jaeger, Eloísa Jiménez Núñez, Jeffrey D. Kearns, Catherine Leblanc, Sauveur-Michel Maira, Jason Murphy, Helen Oakman, Nils Ostermann, Johannes Ottl, Pascal Rigollier, Danielle Roman, Christian Schnell, Richard Sedrani, Toshio Shimizu, Rowan Stringer, Andrea Vaupel, Hans Voshol, Peter Wessels, Toni Widmer, Rainer Wilcken, Kun Xu, Frederic Zecri, Anna F. Farago, Simona Cotesta, Saskia M. Brachmann
Publikováno v:
Cancer Discovery. 12:1500-1517
Covalent inhibitors of KRASG12C have shown antitumor activity against advanced/metastatic KRASG12C-mutated cancers, though resistance emerges and additional strategies are needed to improve outcomes. JDQ443 is a structurally unique covalent inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2edd83624df412b8b1d836bfe665fa6
https://doi.org/10.1158/2159-8290.cd-22-0158
https://doi.org/10.1158/2159-8290.cd-22-0158
Autor:
Daniel S. Tan, Toshio Shimizu, Benjamin Solomon, Rebecca S. Heist, Martin Schuler, Maria J. De Miguel Luken, Anas Gazzah, Martin Wermke, Christophe Dooms, Herbert H. Loong, Neeltje Steeghs, Enriqueta Felip, Conor E. Steuer, Eric van Cutsem, Ross A. Soo, Ashley C. Jaeger, Jaeyeon Kim, Kun Xu, Xueying Chen, Xiaoming Cui, Heather Burks, Anna Farago, Philippe A. Cassier
Publikováno v:
Cancer Research. 82:CT033-CT033
Background: KRAS G12C oncogenic mutations occur in ~13% of non-small cell lung cancers (NSCLCs) and up to 4% of other solid tumors. JDQ443 is a selective, covalent, orally bioavailable, investigational KRASG12C inhibitor that irreversibly traps KRASG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faa820f8810672be7d3134c24567e088
https://doi.org/10.1158/1538-7445.am2022-ct033
https://doi.org/10.1158/1538-7445.am2022-ct033
Autor:
Benjamin Solomon, Rebecca S Heist, Daniel SW Tan, Philippe A Cassier, Christophe Dooms, Eric Van Cutsem, Conor E Steuer, Neeltje Steeghs, Martin Schuler, Anas Gazzah, Martin Wermke, Enriqueta Felip, Herbert HF Loong, Maria J De Miguel Luken, Ross A Soo, Ashley Jaeger, Kun Xu, Xueying Chen, Xiaoming Cui, Heather Burks, Anna F Farago, Toshio Shimizu
Publikováno v:
Molecular Cancer Therapeutics. 20:LBA038-LBA038
Background Kirsten rat sarcoma virus (KRAS) is a GTPase that regulates cell signaling pathways involved in cell proliferation, survival, and tumorigenesis. Somatic mutations in KRAS resulting in a glycine to cysteine substitution at codon 12 (KRAS G1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f22b0ebf312a713620b3e9b94b8bccb1
https://doi.org/10.1158/1535-7163.targ-21-lba038
https://doi.org/10.1158/1535-7163.targ-21-lba038
Autor:
Marinda Li Wu, H. N. Cheng, Bradley D. Miller, Bradley Miller, Tiffany Hoerter, Jakoah Brgoch, William Richard (Rick) Ewing, Katherine Glasgow, Lynne Greenblatt, Laura Kosbar, Beatriz Rios-Mckee, Kimberly A. Woznack, William F. Carroll, Bryan R. Henry, Richard S. Danchik, Morton Z. Hoffman, Zafra M. Lerman, William H. Daly, Adriano D. Andricopulo, T. S. Andy Hor, Markus Behnke, Sanjeev Katti, Ajit Sapre, Peter Koelsch, Eloise Young, Lewis Whitehead, Evans Ogwagwa Changamu, Nina Dudnik, Patrick McCarren, Rajiv Chopra, Rem R. Fazio, David Qualter, Vinod Patel, Ryan Haas, Khampoua Naovarangsy, Bhaveshkumar Gami, Christopher Harwell, Jeffry D. Madura, Heather Burks, Solomon Derese, Michelle Lynn Hall, Ralph Greenberg, Sean Ohlinger, Juliette Pradon, Linda Wang, Lucy Kiruri, Colleen Dionne, Brigitta Tadmor, Jorge L. Colón, Darleane Christian Hoffman, Madeleine Jacobs, Zafra Margolin Lerman, Ann Nalley, Vanderlan da Silva Bolzani, Natacha Carvalho Ferreira Santos, Lydia R. Galagovsky, Barbara Loeb, Noemí Elisabeth Walsöe de Reca, Gheorghiţa Jinescu
Publikováno v:
Chemistry - A European Journal. 12:8708-8718
Two isomeric salicylic aldehyde nucleobases have been prepared and incorporated into various DNA duplexes. Reaction with ethylenediamine leads to formation of the well-known salen ligand inside the DNA double helix. Addition of transition-metal ions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8f1a4f0f2a70b0ba17f0d5d1f0483a
https://doi.org/10.1002/chem.200600558
https://doi.org/10.1002/chem.200600558
Publikováno v:
Synthesis; Feb2005, Vol. 2005 Issue 2, p330-333, 4p