Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Heather Boux"'
Autor:
Girija Krishnamurthy, Sheetal Mehta, Lei Zhang, Harbhajan Dhillon, Hangtian Song, Heather Boux, Deepti Ahluwalia, Anulfo Valdez, Thomas R. Slaney
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 141:32-38
Residual host cell proteins (HCPs) are process-related impurities present in biotherapeutics that can pose safety health risks to patients. An adequate control of HCP levels in the final product, and demonstration of HCP clearance throughout a produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659109dda6bd3b75dda6e869b63168b4
https://doi.org/10.1016/j.jpba.2017.03.065
https://doi.org/10.1016/j.jpba.2017.03.065
Autor:
Shun Shimohama, Atsushi Takeda, Catherine A. Rottkamp, George Perry, Mark A. Smith, Anthony W. Hartzler, Zheng Sun, Xiongwei Zhu, Heather Boux
Publikováno v:
Journal of Neurochemistry. 79:311-318
Mitogen-activated protein kinase (MAPK) p38 has been implicated in the pathogenesis of Alzheimer's disease, but the upstream cascade leading to p38 activation has not been elucidated in the disease. In the present study, we focused on mitogen-activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8835cccb64bf3d544a8da0e875abf515
https://doi.org/10.1046/j.1471-4159.2001.00597.x
https://doi.org/10.1046/j.1471-4159.2001.00597.x
Autor:
Xiongwei Zhu, Heather Boux, George Perry, Mark A. Smith, Rudolph J. Castellani, Catherine A. Rottkamp, Sandra L. Siedlak, Arun K. Raina, Akihiko Nunomura, Ayala Hochman
Publikováno v:
Acta Neuropathologica. 101:305-310
Multiple studies suggest that neuronal death in Alzheimer's disease (AD) is the result of an apoptotic mechanism. However, the stereotypical manifestations that define the terminal phases of apoptosis, such as chromatin condensation, apoptotic bodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1487fa31552c826c4f3a9627d7922c
https://doi.org/10.1007/s004010100378
https://doi.org/10.1007/s004010100378
Autor:
Mark A. Smith, Gregory J. Brewer, Catherine A. Rottkamp, Arun K. Raina, Hossein A. Ghanbari, Xiongwei Zhu, Heather Boux
Publikováno v:
Neurobiology of Aging. 21:807-813
Despite their supposedly terminally-differentiated quiescent status, many neurons in Alzheimer disease display an ectopic re-expression of cell-cycle related proteins. In the highly regulated process of cell cycle, cyclin-dependent kinase 7 (Cdk7) pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a541a0c482441f8f89d2921eb32e66
https://doi.org/10.1016/s0197-4580(00)00217-7
https://doi.org/10.1016/s0197-4580(00)00217-7
Autor:
Mark A. Smith, Arun K. Raina, Catherine A. Rottkamp, Xiongwei Zhu, Heather Boux, George Perry, Gjumrakch Aliev
Publikováno v:
Journal of neurochemistry. 76(2)
Cellular responses to increased oxidative stress appear to be a mechanism that contributes to the varied cytopathology of Alzheimer's disease (AD). In this regard, we suspect that c-Jun N-terminal kinase/Stress activated protein kinase (JNK/SAPK), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b47a18fb200fb12b9616fd8ddee9cc5
https://pubmed.ncbi.nlm.nih.gov/11208906
https://pubmed.ncbi.nlm.nih.gov/11208906
Autor:
Atushi Takeda, Mark A. Smith, Xiongwei Zhu, Heather Boux, Catherine A. Rottkamp, George Perry
Publikováno v:
Journal of neuropathology and experimental neurology. 59(10)
The temporal association between oxidative stress and the hallmark pathologies of Alzheimer disease (AD) demonstrates that oxidative stress is among the earliest events in the disease. Nonetheless, neither the consequences of oxidative stress nor how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f41f45a36564848cc1f068fcf5f6e8
https://pubmed.ncbi.nlm.nih.gov/11079778
https://pubmed.ncbi.nlm.nih.gov/11079778
Publikováno v:
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 18(4-5)
A number of recent findings have highlighted the similarities between neurogenesis during development and neurodegeneration during Alzheimer disease. In fact, neuronal populations that are known to degenerate in Alzheimer disease exhibit phenotypic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998ed25edec09cde63a224b1a2e3de67
https://pubmed.ncbi.nlm.nih.gov/10817927
https://pubmed.ncbi.nlm.nih.gov/10817927
Autor:
Mark A. Smith, Xiongwei Zhu, Heather Boux, George Perry, Atsushi Takeda, Catherine A. Rottkamp, Sandra L. Siedlak, Arun K. Raina
Publikováno v:
Neurobiology of Aging. 21:267
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc70d977ca37f520a7beac264908ed03
https://doi.org/10.1016/s0197-4580(00)83154-1
https://doi.org/10.1016/s0197-4580(00)83154-1