Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Heather Bechtel"'
Autor:
Graham Brown, Gregory M. Vercellotti, John D. Belcher, Karl A. Nath, Heather Bechtel, Robert P. Hebbel, Fatima Khan, Carol M. Bruzzone, Chunsheng Chen, Julia Nguyen, Clifford J. Steer
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Frontiers in Pharmacology
Frontiers in Pharmacology
Hemolysis, oxidative stress, inflammation, vaso-occlusion, and organ infarction are hallmarks of sickle cell disease (SCD). We have previously shown that increases in heme oxygenase-1 (HO-1) activity detoxify heme and inhibit vaso-occlusion in transg
Publikováno v:
Pediatric Blood & Cancer. 56:674-676
Deferasirox (Exjade®, Novartis) is a widely used oral iron chelator for the treatment of patients with iron overload due to chronic transfusion therapy for diseases such as β-thalassemia and sickle cell disease. Renal side effects of deferasirox ar
Publikováno v:
Pediatric bloodcancer. 56(4)
Deferasirox (Exjade®, Novartis) is a widely used oral iron chelator for the treatment of patients with iron overload due to chronic transfusion therapy for diseases such as β-thalassemia and sickle cell disease. Renal side effects of deferasirox ar
Autor:
Chunsheng Chen, John D. Belcher, Gregory M. Vercellotti, Heather Bechtel, Robert P. Hebbel, Julia Ngyuen, Carol M. Bruzzone, Clifford J. Steer
Publikováno v:
Blood. 120:378-378
Abstract 378 Hemolysis, oxidative stress, inflammation, vaso-occlusion and organ infarction are hallmarks of sickle cell disease (SCD). We hypothesize that intravascular heme, liberated from hemoglobin S derived from hemolyzed sickle red blood cells,