Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Heather B, Jaspan"'
Autor:
Sonwabile Dzanibe, Aaron J. Wilk, Susan Canny, Thanmayi Ranganath, Berenice Alinde, Florian Rubelt, Huang Huang, Mark M. Davis, Susan P. Holmes, Heather B. Jaspan, Catherine A. Blish, Clive M. Gray
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract While preventing vertical HIV transmission has been very successful, HIV-exposed uninfected infants (iHEU) experience an elevated risk to infections compared to HIV-unexposed and uninfected infants (iHUU). Here we present a longitudinal mult
Externí odkaz:
https://doaj.org/article/44079eeedfed4aefb26588fb0716959c
Autor:
Anna-Ursula Happel, Lerato Rametse, Brandon Perumaul, Christian Diener, Sean M. Gibbons, Donald D. Nyangahu, Kirsten A. Donald, Clive Gray, Heather B. Jaspan
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Introduction Infants who are born from mothers with HIV (infants who are HIV exposed but uninfected; iHEU) are at higher risk of morbidity and display multiple immune alterations compared to infants who are HIV-unexposed (iHU). Easily implem
Externí odkaz:
https://doaj.org/article/0ee278c7d60d433597ec6efe539d511a
Autor:
Saori C. Iwase, Sophia Osawe, Anna-Ursula Happel, Clive M. Gray, Susan P. Holmes, Jonathan M. Blackburn, Alash'le Abimiku, Heather B. Jaspan
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTInfants who are exposed to HIV but uninfected (iHEU) have higher risk of infectious morbidity than infants who are HIV-unexposed and uninfected (iHUU), possibly due to altered immunity. As infant gut microbiota may influence immune developmen
Externí odkaz:
https://doaj.org/article/def87cd9e69c4d0baa3cd6082d15c7e7
Autor:
Brandon S. Maust, Stefan Petkov, Carolina Herrera, Colin Feng, Bryan P. Brown, Limakatso Lebina, Daniel Opoka, Andrew Ssemata, Natasha Pillay, Jennifer Serwanga, Portia Seatlholo, Patricia Namubiru, Geoffrey Odoch, Susan Mugaba, Thabiso Seiphetlo, Clive M. Gray, Pontiano Kaleebu, Emily L. Webb, Neil Martinson, Francesca Chiodi, Julie Fox, Heather B. Jaspan
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e22145- (2023)
The penile epithelial microbiome remains underexplored. We sequenced human RNA and a segment of the bacterial 16S rRNA gene from the foreskin tissue of 144 adolescents from South Africa and Uganda collected during penile circumcision after receipt of
Externí odkaz:
https://doaj.org/article/093446e9cd8343b3a1ef661a6ba73eb8
Autor:
Bryan P. Brown, Colin Feng, Ramla F. Tanko, Shameem Z. Jaumdally, Rubina Bunjun, Smritee Dabee, Anna-Ursula Happel, Melanie Gasper, Donald D. Nyangahu, Maricianah Onono, Gonasagrie Nair, Thesla Palanee-Phillips, Caitlin W. Scoville, Kate Heller, Jared M. Baeten, Steven E. Bosinger, Adam Burgener, Jo-Ann S. Passmore, Renee Heffron, Heather B. Jaspan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Here, in a randomized trial, the authors comparatively evaluate the effect of a copper intrauterine device versus other contraceptive options on the vaginal environment after one and six consecutive months of use, finding to exert changes on the vagi
Externí odkaz:
https://doaj.org/article/8a9c0bc428c344ff979412c501522583
Autor:
Smritee Dabee, Nelly Mugo, Victor Mudhune, Eleanor McLellan-Lemal, Sue Peacock, Siobhan O’Connor, Betty Njoroge, Beatrice Nyagol, Andrea R. Thurman, Eunice Ouma, Renee Ridzon, Jeffrey Wiener, Harald S. Haugen, Melanie Gasper, Colin Feng, Shannon A. Allen, Gustavo F. Doncel, Heather B. Jaspan, Renee Heffron, Kisumu Combined Ring Study Team
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract In a phase-IIa trial, we investigated the influence of 90 days continuous-delivery tenofovir (TFV) intravaginal rings (IVRs) with/without levonorgestrel (LNG) on the genital microbiota of Kenyan women. Eligible women (n = 27; 18–34 years;
Externí odkaz:
https://doaj.org/article/68fd82a48b804787804310a51e78d2ca
Autor:
Donald D. Nyangahu, Courtney R. Plumlee, Bryan P. Brown, Colin Feng, Enock Havyarimana, Sara B. Cohen, Kevin B. Urdahl, Heather B. Jaspan
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Whether antibiotic treatment during gestation impacts T cell immunity to vaccination in offspring is unexplored. Dams treated with polymyxin B (PMB) during gestation (Mg) displayed altered microbial communities prior to delivery compared to
Externí odkaz:
https://doaj.org/article/c3f90140fb294d4f9423d4d78a810a11
Autor:
Christina Balle, Blair Armistead, Agano Kiravu, Xiaochang Song, Anna-Ursula Happel, Angela A. Hoffmann, Sami B. Kanaan, J. Lee Nelson, Clive M. Gray, Heather B. Jaspan, Whitney E. Harrington
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Determinants of the acquisition and maintenance of maternal microchimerism (MMc) during infancy and the impact of MMc on infant immune responses are unknown. We examined factors that influence MMc detection and level across infancy and the effect of
Externí odkaz:
https://doaj.org/article/3588c1c905544c6b8af0137f2b91e6b3
Autor:
Anna-Ursula Happel, Christina Balle, Enock Havyarimana, Bryan Brown, Brandon S. Maust, Colin Feng, Byung H. Yi, Katherine Gill, Linda-Gail Bekker, Jo-Ann S. Passmore, Heather B. Jaspan, Arvind Varsani
Publikováno v:
Viruses, Vol 15, Iss 3, p 758 (2023)
The interaction between cervicovaginal virome, bacteriome and genital inflammation has not been extensively investigated. We assessed the vaginal DNA virome from 33 South African adolescents (15–19 years old) using shotgun DNA sequencing of purifie
Externí odkaz:
https://doaj.org/article/d4f753e20ce441649c83f2fa38cdad4f
Autor:
Anna-Ursula Happel, Melanie Gasper, Christina Balle, Iyaloo Konstantinus, Hoyam Gamieldien, Smritee Dabee, Katherine Gill, Linda-Gail Bekker, Jo-Ann S. Passmore, Heather B. Jaspan
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Cervicovaginal inflammation, nonoptimal microbiota, T-cell activation, and hormonal contraceptives may increase HIV risk, yet associations between these factors and subclinical Candida colonization or hyphae are unknown. We collected cervico
Externí odkaz:
https://doaj.org/article/677fd1cf332b4938be28d9bd84b16e31