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pro vyhledávání: '"Heather Andro"'
Publikováno v:
Atherosclerosis
Background and aims We previously demonstrated that Apoe−/− mice on DBA/2 vs. AKR genetic background have >10-fold larger atherosclerotic lesions. Prior quantitative trait locus mapping via strain intercrossing identified a region on chromosome 1
Autor:
Heather Andro, Jonathan D. Smith, Kailash Gulshan, Jennie E. Hazen, Harvey Lewis, Amanda J Iacano
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Miltefosine is an FDA approved oral drug for treating cutaneous and visceral leishmaniasis. Leishmania is a flagellated protozoa, which infects and differentiates in macrophages. Here, we studied the effects of Miltefosine on macrophage’s lipid hom
Autor:
Brian Ritchey, Harvey Lewis, Jonathan D. Smith, Amanda J Iacano, Kailash Gulshan, Shuhui Wang Lorkowski, Jennie E. Hazen, Greg Brubaker, Heather Andro, Bani A Raheem
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Introduction: The NLRP3 inflammasome and Toll-like receptor signaling is activated in advanced human atherosclerotic plaques, while autophagy and reverse cholesterol transport (RCT) become dysfunctional. Simultaneous targeting of these pathways can p