Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Heather A. Skynner"'
Autor:
Ignacio Munoz-Sanjuan, Heather A. Skynner, Doran P. Amos, Fraser Murray, Luis M. Camargo, Paul C. Guest, M.R. Knowles, Kamran Salim, Timothy P. Bonnert
Publikováno v:
Brain Research. 1102:12-26
Some patients with Major Depression and other neurological afflictions display hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. HPA hyperactivity may be due to impaired feedback inhibition and manifested as increased levels of circulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd3a632f15e2d4791fcf0c46b6b405b
https://doi.org/10.1016/j.brainres.2006.04.112
https://doi.org/10.1016/j.brainres.2006.04.112
Autor:
Jamil I. Bacha, George McAllister, Heather A. Skynner, Tim Bonnert, Paul C. Guest, Kamran Salim, Julie Kerby, Hector Urien-Rodriguez, Margaret S. Beer, Anne Heald, Tim R. Fenton, Emma Watts
Publikováno v:
Journal of Biological Chemistry. 277:15482-15485
Recent studies have shown that G-protein-coupled receptors (GPCRs) can assemble as high molecular weight homo- and hetero-oligomeric complexes. This can result in altered receptor-ligand binding, signaling, or intracellular trafficking. We have co-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745eed80c5d9cc20d61cdeb70a7a087f
https://doi.org/10.1074/jbc.m201539200
https://doi.org/10.1074/jbc.m201539200
Autor:
Heather A. Skynner, Paul C. Guest, Kamran Salim, George McAllister, Ignacio Munoz-Sanjuan, James G. Bilsland, Timothy P. Bonnert
Publikováno v:
Stem cells and development. 16(1)
The use of neural precursor cells (NPCs) represents a promising repair strategy for many neurological disorders. However, the molecular events and biological features that control NPC proliferation and their differentiation into neurons, astrocytes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b682d5a5e9aadd3ea6b655fcddcf1b2
https://pubmed.ncbi.nlm.nih.gov/17233554
https://pubmed.ncbi.nlm.nih.gov/17233554
Autor:
Jeffrey W. Lawrence, Michael R. Knowles, Russell J. Mortishire-Smith, Kamran Salim, Georgina Meneses-Lorente, Heather A. Skynner, Paul C. Guest, Simon J. Gaskell, Ileana M. Cristea, Nagaraja Muniappa, Alan P. Watt
Publikováno v:
Chemical research in toxicology. 17(5)
A significant problem faced by pharmaceutical companies today is the failure of lead compounds in the later stages of development due to unexpected toxicities. We have used two-dimensional differential in-gel electrophoresis and mass spectrometry to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5797d653eb912499111c06c02bafdf
https://pubmed.ncbi.nlm.nih.gov/15144217
https://pubmed.ncbi.nlm.nih.gov/15144217
Autor:
Paul A. Negulescu, Kevin Beaumont, Janine N. Bresnick, Andrew D. Jack, Smita Patel, Kerry L. Chapman, Heather A. Skynner, George McAllister, Elize Zamiara
Publikováno v:
Assay and drug development technologies. 1(2)
The superfamily of GPCRs have diverse biological roles, transducing signals from a range of stimuli, from photon recognition by opsins to neurotransmitter regulation of neuronal function. Of the many identified genes encoding GPCRs,130 are orphan rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ed1e4b7199b498dcfb90374244b7da
https://pubmed.ncbi.nlm.nih.gov/15090189
https://pubmed.ncbi.nlm.nih.gov/15090189
Autor:
Heather A. Skynner, Stephen P. Hunt, Paul C. Guest, Kamran Salim, Carmen De Felipe, George McAllister, Sandra Cervino, Georgina Meneses-Lorente, M.R. Knowles
Publikováno v:
Proteomics. 3(7)
This paper describes the use of fluorescence two-dimensional differential in-gel electrophoresis in a multiplex analysis of two distinct proteomes. As a model system, cerebral cortex tissues were analyzed from neurokinin1 receptor knockout (NK(1)R-/-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bfa7884acc25b53b20a17f3bf0e748
https://pubmed.ncbi.nlm.nih.gov/12872217
https://pubmed.ncbi.nlm.nih.gov/12872217
Autor:
Heather A, Skynner, Thomas W, Rosahl, Michael R, Knowles, Kamran, Salim, Lee, Reid, Rosa, Cothliff, George, McAllister, Paul C, Guest
Publikováno v:
Proteomics. 2(8)
Transgenic, knockout and knockin mice are useful tools for linking specific genes with behaviour and other complex biological processes. However, complications arising due to compensatory changes, genetic background differences and other factors coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bfea17e3f04570a1fb7686e604e0b96
https://pubmed.ncbi.nlm.nih.gov/12203897
https://pubmed.ncbi.nlm.nih.gov/12203897
Autor:
Paul C. Guest, Kamran Salim, George McAllister, Heather A. Skynner, Samantha E. George, Janine N. Bresnick
Publikováno v:
Brain research. 876(1-2)
We have identified an alternatively spliced 5-hydroxytryptamine 2A receptor (5-HT(2A)-R) transcript by PCR of human brain cDNA using degenerate oligonucleotide primers to transmembrane (TM) domains 3 and 7 of the 5-HT(2)-R subfamily. The variant cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64baa2160de899f2df2210eed25e23a9
https://pubmed.ncbi.nlm.nih.gov/10973616
https://pubmed.ncbi.nlm.nih.gov/10973616
Autor:
M.R. Knowles, Lee Reid, Thomas W. Rosahl, Rosa Cothliff, George McAllister, Paul C. Guest, Kamran Salim, Heather A. Skynner
Publikováno v:
PROTEOMICS. 2:1018
Transgenic, knockout and knockin mice are useful tools for linking specific genes with behaviour and other complex biological processes. However, complications arising due to compensatory changes, genetic background differences and other factors coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aa1f45c4ca2372bb2eebf4b2a6949c6
https://doi.org/10.1002/1615-9861(200208)2:8<1018::aid-prot1018>3.0.co
https://doi.org/10.1002/1615-9861(200208)2:8<1018::aid-prot1018>3.0.co
Autor:
Kamran Salim, Paul C. Guest, Heather A. Skynner, James G. Bilsland, Timothy P. Bonnert, George McAllister, Ignacio Munoz-Sanjuan
Publikováno v:
Stem Cells & Development; Feb2007, Vol. 16 Issue 1, p143-166, 24p