Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Heather A. Skynner"'
Autor:
Ignacio Munoz-Sanjuan, Heather A. Skynner, Doran P. Amos, Fraser Murray, Luis M. Camargo, Paul C. Guest, M.R. Knowles, Kamran Salim, Timothy P. Bonnert
Publikováno v:
Brain Research. 1102:12-26
Some patients with Major Depression and other neurological afflictions display hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. HPA hyperactivity may be due to impaired feedback inhibition and manifested as increased levels of circulat
Autor:
Jamil I. Bacha, George McAllister, Heather A. Skynner, Tim Bonnert, Paul C. Guest, Kamran Salim, Julie Kerby, Hector Urien-Rodriguez, Margaret S. Beer, Anne Heald, Tim R. Fenton, Emma Watts
Publikováno v:
Journal of Biological Chemistry. 277:15482-15485
Recent studies have shown that G-protein-coupled receptors (GPCRs) can assemble as high molecular weight homo- and hetero-oligomeric complexes. This can result in altered receptor-ligand binding, signaling, or intracellular trafficking. We have co-tr
Autor:
Heather A. Skynner, Paul C. Guest, Kamran Salim, George McAllister, Ignacio Munoz-Sanjuan, James G. Bilsland, Timothy P. Bonnert
Publikováno v:
Stem cells and development. 16(1)
The use of neural precursor cells (NPCs) represents a promising repair strategy for many neurological disorders. However, the molecular events and biological features that control NPC proliferation and their differentiation into neurons, astrocytes,
Autor:
Jeffrey W. Lawrence, Michael R. Knowles, Russell J. Mortishire-Smith, Kamran Salim, Georgina Meneses-Lorente, Heather A. Skynner, Paul C. Guest, Simon J. Gaskell, Ileana M. Cristea, Nagaraja Muniappa, Alan P. Watt
Publikováno v:
Chemical research in toxicology. 17(5)
A significant problem faced by pharmaceutical companies today is the failure of lead compounds in the later stages of development due to unexpected toxicities. We have used two-dimensional differential in-gel electrophoresis and mass spectrometry to
Autor:
Paul A. Negulescu, Kevin Beaumont, Janine N. Bresnick, Andrew D. Jack, Smita Patel, Kerry L. Chapman, Heather A. Skynner, George McAllister, Elize Zamiara
Publikováno v:
Assay and drug development technologies. 1(2)
The superfamily of GPCRs have diverse biological roles, transducing signals from a range of stimuli, from photon recognition by opsins to neurotransmitter regulation of neuronal function. Of the many identified genes encoding GPCRs,130 are orphan rec
Autor:
Heather A. Skynner, Stephen P. Hunt, Paul C. Guest, Kamran Salim, Carmen De Felipe, George McAllister, Sandra Cervino, Georgina Meneses-Lorente, M.R. Knowles
Publikováno v:
Proteomics. 3(7)
This paper describes the use of fluorescence two-dimensional differential in-gel electrophoresis in a multiplex analysis of two distinct proteomes. As a model system, cerebral cortex tissues were analyzed from neurokinin1 receptor knockout (NK(1)R-/-
Autor:
Heather A, Skynner, Thomas W, Rosahl, Michael R, Knowles, Kamran, Salim, Lee, Reid, Rosa, Cothliff, George, McAllister, Paul C, Guest
Publikováno v:
Proteomics. 2(8)
Transgenic, knockout and knockin mice are useful tools for linking specific genes with behaviour and other complex biological processes. However, complications arising due to compensatory changes, genetic background differences and other factors coul
Autor:
Paul C. Guest, Kamran Salim, George McAllister, Heather A. Skynner, Samantha E. George, Janine N. Bresnick
Publikováno v:
Brain research. 876(1-2)
We have identified an alternatively spliced 5-hydroxytryptamine 2A receptor (5-HT(2A)-R) transcript by PCR of human brain cDNA using degenerate oligonucleotide primers to transmembrane (TM) domains 3 and 7 of the 5-HT(2)-R subfamily. The variant cont
Autor:
M.R. Knowles, Lee Reid, Thomas W. Rosahl, Rosa Cothliff, George McAllister, Paul C. Guest, Kamran Salim, Heather A. Skynner
Publikováno v:
PROTEOMICS. 2:1018
Transgenic, knockout and knockin mice are useful tools for linking specific genes with behaviour and other complex biological processes. However, complications arising due to compensatory changes, genetic background differences and other factors coul
Autor:
Kamran Salim, Paul C. Guest, Heather A. Skynner, James G. Bilsland, Timothy P. Bonnert, George McAllister, Ignacio Munoz-Sanjuan
Publikováno v:
Stem Cells & Development; Feb2007, Vol. 16 Issue 1, p143-166, 24p