Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Heather A. Shankowsky"'
Autor:
Takashi Iwashina, Heather A. Shankowsky, Jie Ding, Zengshuan Ma, Edward E. Tredget, Hongbin Liu, Peter Kwan, Donald Wong
Publikováno v:
Wound Repair and Regeneration. 22:622-630
Effective prevention and treatment of hypertrophic scars (HTSs), a dermal form of fibrosis that frequently occurs following thermal injury to deep dermis, are unsolved significant clinical problems. Previously, we have found that stromal cell-derived
Publikováno v:
Journal of Burn Care & Research. 35:251-256
Heterotopic ossification (HO) is a clinical condition of ectopic bone formation in soft tissue. This clinical entity has been associated with genetic disorders, traumatic injuries, and musculoskeletal surgeries. In this regard, functional impairments
Publikováno v:
Wound Repair and Regeneration. 21:448-455
Hypertrophic scars are a significant fibroproliferative disorder complicating deep injuries to the skin. We hypothesize that activated deep dermal fibroblasts are subject to regulation by bone marrow-derived mesenchymal stem cells (BM-MSCs), which le
Publikováno v:
Journal of Burn Care & Research. 33:668-677
Hypertrophic scar (HTS) represents the dermal equivalent of fibroproliferative disorders. Fibroblasts from the deep dermis are implicated in the development of HTS after injuries that involve deeper areas of the skin. However, fibroblasts that reside
Autor:
Edward E. Tredget, Dariush Honardoust, Yvonne Marcoux, Jie Ding, Heather A. Shankowsky, Keijiro Hori, Rainny Zhang
Publikováno v:
Wound Repair and Regeneration. 19:568-578
Recent data support the involvement of stromal cell-derived factor 1 (SDF-1) in the homing of bone marrow-derived stem cells to wound sites during skeletal, myocardial, vascular, lung, and skin wound repair as well as some fibrotic disorders via its
Autor:
Keijiro Hori, Dariush Honardoust, Mathew Varkey, Jie Ding, Heather A. Shankowsky, Edward E. Tredget
Publikováno v:
Wound Repair and Regeneration. 19:368-378
Small leucine-rich proteoglycans (SLRPs) are extracellular matrix molecules that regulate collagen fibrillogenesis and inhibit transforming growth factor-β activity; thus, they may play a critical role in wound healing and scar formation. Hypertroph
Autor:
Jie Ding, Heather A. Shankowsky, Haiyan Jiao, Moein Momtazi, Edward E. Tredget, JianFei Wang, Dariush Honardoust
Publikováno v:
Wound Repair and Regeneration. 19:274-285
Hypertrophic scar (HTS) following thermal injury and other forms of trauma is a dermal fibroproliferative disorder that leads to considerable morbidity. Because of the lack of an ideal animal model, research is difficult. We have established an HTS m
Autor:
Edward E. Tredget, Carole M. Dodd, Farrah Yau, Abelardo Medina, Heather A. Shankowsky, Ayman Banjar, Paul G. Scott, Aziz Ghahary
Publikováno v:
Wound Repair and Regeneration. 13:A28-A48
Introduction: Fibrocytes are a unique bone marrow origin leukocyte subpopulation which display fibroblast-like properties and are antigen-presenting cells that are up-regulated systemically after burn injury. This study investigated their role in FPD
Autor:
Paul G. Scott, Megan V. H. Lyons, Heather A. Shankowsky, Tara L. Stewart, Haiyan Jiao, Edward E. Tredget, JianFei Wang
Publikováno v:
Journal of Leukocyte Biology. 82:1554-1563
Wound healing is a complex process involving the integrated actions of numerous cell types, soluble mediators, and ECM. Recently, a newly identified cell type, the fibrocyte, has been reported to contribute to wound healing and fi- brotic conditions
Autor:
Haiyan Jiao, Tara L. Stewart, Paul G. Scott, Edward E. Tredget, Heather A. Shankowsky, JianFei Wang
Publikováno v:
Wound Repair and Regeneration. 15:530-539
The development of hypertrophic scar involves a complex interplay between cells and cytokines. Although the mechanism underlying its pathogenesis is not well understood, a polarized T-helper type 2 immune response has been reported, indicating a role