Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Heather A. Martin"'
Autor:
Sophie J. Heseltine, Gregory J. Billenness, Heather L Martin, Christian Tiede, Anna A.S. Tang, Eleanor Foy, Grace Reddy, Naomi Gibson, Matt Johnson, Michael E. Webb, Michael J. McPherson, Darren C. Tomlinson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Despite SH2 domains, being pivotal in protein interactions linked to various diseases like cancer, we lack specific research tools for intracellular assays. Understanding SH2-mediated interactions and creating effective inhibitors requires t
Externí odkaz:
https://doaj.org/article/897c250a45ca4c918029c347c9003027
Autor:
Sophie E. Roberts, Heather L. Martin, Danah Al-Qallaf, Anna A. Tang, Christian Tiede, Thembaninkosi G. Gaule, Albor Dobon-Alonso, Ross Overman, Sachin Shah, Hadrien Peyret, Keith Saunders, Robin Bon, Iain W. Manfield, Sandra M. Bell, George P. Lomonossoff, Valerie Speirs, Darren C. Tomlinson
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110461- (2024)
Summary: Monoclonal antibodies have revolutionized therapies, but non-immunoglobulin scaffolds are becoming compelling alternatives owing to their adaptability. Their ability to be labeled with imaging or cytotoxic compounds and to create multimeric
Externí odkaz:
https://doaj.org/article/afbbfa1f915d4d408b05c261d3880b47
Autor:
Philip T. Coleman, Gabriel W. Costanza-Chavez, Heather N. Martin, Jose Amat, Matthew G. Frank, Rory J. Sanchez, Garrett J. Potter, Simone M. Mellert, Rene K. Carter, Gianni N. Bonnici, Steven F. Maier, Michael V. Baratta
Publikováno v:
Neurobiology of Stress, Vol 28, Iss , Pp 100597- (2024)
Dominance status has extensive effects on physical and mental health, and an individual's relative position can be shaped by experiential factors. A variety of considerations suggest that the experience of behavioral control over stressors should pro
Externí odkaz:
https://doaj.org/article/3784a2524a934ec8a8217c383f1455a9
Autor:
Heather L. Martin, Amy L. Turner, Julie Higgins, Anna A. Tang, Christian Tiede, Thomas Taylor, Sitthinon Siripanthong, Thomas L. Adams, Iain W. Manfield, Sandra M. Bell, Ewan E. Morrison, Jacquelyn Bond, Chi H. Trinh, Carolyn D. Hurst, Margaret A. Knowles, Richard W. Bayliss, Darren C. Tomlinson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113184- (2023)
Summary: Kinases are important therapeutic targets, and their inhibitors are classified according to their mechanism of action, which range from blocking ATP binding to covalent inhibition. Here, a mechanism of inhibition is highlighted by capturing
Externí odkaz:
https://doaj.org/article/602d6e2e2cea4be1917c7c7c7b34ebd6
Autor:
Katarzyna Z. Haza, Heather L. Martin, Ajinkya Rao, Amy L. Turner, Sophie E. Saunders, Britta Petersen, Christian Tiede, Kevin Tipping, Anna A. Tang, Modupe Ajayi, Thomas Taylor, Maia Harvey, Keri M. Fishwick, Thomas L. Adams, Thembaninkosi G. Gaule, Chi H. Trinh, Matthew Johnson, Alexander L. Breeze, Thomas A. Edwards, Michael J. McPherson, Darren C. Tomlinson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Oncogenic RAS mutants remain difficult to target with small molecules. Here, the authors show that RAS-binding Affimer proteins inhibit RAS signaling while binding diverse regions on the RAS surface, suggesting the potential to use Affimers as tools
Externí odkaz:
https://doaj.org/article/9fb0e318fb534431a1e30f0ac4d27ca1
Autor:
Heather J. Martin, Amanda Schwartz
Publikováno v:
Journal of the Medical Library Association, Vol 108, Iss 4 (2020)
While institutional repositories are common in medical schools and academic health centers, they have been used by only a small number of health systems to track and promote their research and scholarly activity. This article describes how Providence
Externí odkaz:
https://doaj.org/article/b8089d1d9707451fbdf343a2762e7b41
Publikováno v:
Adapting the Past to Reimagine Possible Futures: Celebrating and Critiquing WAC at 50 ISBN: 9781642151947
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cf8a1e63c0dad70ae7891039aa08d55
https://doi.org/10.37514/per-b.2023.1947.2.01
https://doi.org/10.37514/per-b.2023.1947.2.01
Autor:
Carlos Munoz-Zuluaga, Monica Gertz, Melissa Yost-Bido, Alessandria Greco, Nicholas Gorman, Alvin Chen, Vikrum Kooner, Jonathan B Rosenberg, Bishnu P De, Stephen M. Kaminsky, Alain Bborczuk, Rodolfo Ricart Arbona, Heather R Martin, Sebastien Monette, Richie Khanna, Jay A Barth, Ronald G Crystal, Dolan Sondhi
Publikováno v:
Human Gene Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ffa6e8de23673ee4afe80b78df1357a
https://doi.org/10.1089/hum.2023.020
https://doi.org/10.1089/hum.2023.020
Autor:
Mariah R. Erlick, Marsha Pulhamus, Jan Schriefer, Kimberly Buholtz, Michelle DiRaddo, Theresa Foito, Colleen Hill-Sober, Elizabeth Levatino, Samantha K. Neumeister, Tina Sosa, Luis I. Ruffolo, Sarah Verna, Derek S. Wakeman, Heather A. Martin
Publikováno v:
Journal of Pediatric Surgical Nursing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b35228f8b677c97841bf3cfbb6e5e604
https://doi.org/10.1097/jps.0000000000000377
https://doi.org/10.1097/jps.0000000000000377
Autor:
Matteo Santoro, Walter Maetzler, Petros Stathakos, Heather L. Martin, Markus A. Hobert, Tim W. Rattay, Thomas Gasser, John V. Forrester, Daniela Berg, Kevin J. Tracey, Gernot Riedel, Peter Teismann
Publikováno v:
Neurobiology of Disease, Vol 91, Iss , Pp 59-68 (2016)
High-mobility group box 1 (HMGB1) is a nuclear and cytosolic protein that is released during tissue damage from immune and non-immune cells — including microglia and neurons. HMGB1 can contribute to progression of numerous chronic inflammatory and
Externí odkaz:
https://doaj.org/article/4abb6cad582648929eac5ff3eeb821c5