Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Heather A. Lee"'
Autor:
Sam Humphries, Danielle R. Bond, Zacary P. Germon, Simon Keely, Anoop K. Enjeti, Matthew D. Dun, Heather J. Lee
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background Acute myeloid leukaemia (AML) is a deadly disease characterised by the uncontrolled proliferation of immature myeloid cells within the bone marrow. Altered regulation of DNA methylation is an important epigenetic driver of AML, wh
Externí odkaz:
https://doaj.org/article/d597cb67e38b4e099ab81bff5d446bde
Autor:
Iromi Wanigasuriya, Sarah A. Kinkel, Tamara Beck, Ellise A. Roper, Kelsey Breslin, Heather J. Lee, Andrew Keniry, Matthew E. Ritchie, Marnie E. Blewitt, Quentin Gouil
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-11 (2022)
Abstract Embryonic development is dependent on the maternal supply of proteins through the oocyte, including factors setting up the adequate epigenetic patterning of the zygotic genome. We previously reported that one such factor is the epigenetic re
Externí odkaz:
https://doaj.org/article/e4430fcb138444b3b279b1aab8b8b2b5
Autor:
Kooper V. Hunt, Sean M. Burnard, Ellise A. Roper, Danielle R. Bond, Matthew D. Dun, Nicole M. Verrills, Anoop K. Enjeti, Heather J. Lee
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Global changes in DNA methylation are observed in development and disease, and single-cell analyses are highlighting the heterogeneous regulation of these processes. However, technical challenges associated with single-cell analysis of DNA m
Externí odkaz:
https://doaj.org/article/73119636505547c88c866348273eac38
Autor:
Holly C.L. Pearson, Kooper V. Hunt, Toby N. Trahair, Richard B. Lock, Heather J. Lee, Charles E. de Bock
Publikováno v:
HemaSphere, Vol 6, Iss 6, p e734 (2022)
Drug resistance and treatment failure in pediatric acute lymphoblastic leukemia (ALL) are in part driven by tumor heterogeneity and clonal evolution. Although bulk tumor genomic analyses have provided some insight into these processes, single-cell se
Externí odkaz:
https://doaj.org/article/71869efe7d01412fa75e2cd2ed105ff7
Publikováno v:
Frontiers in Conservation Science, Vol 2 (2021)
Although supplemental feeding is commonly used as a conservation strategy during animal translocations, it comes with a number of pros and cons which can be hard to quantify. Providing additional food resources may lead to improved physical health, s
Externí odkaz:
https://doaj.org/article/2dd25d5f96364a4787599d78186c5c3a
Publikováno v:
In Learning and Motivation May 2019 66:22-33
Publikováno v:
Hong Kong Medical Journal. 29:66-69
Autor:
Iromi Wanigasuriya, Quentin Gouil, Sarah A Kinkel, Andrés Tapia del Fierro, Tamara Beck, Ellise A Roper, Kelsey Breslin, Jessica Stringer, Karla Hutt, Heather J Lee, Andrew Keniry, Matthew E Ritchie, Marnie E Blewitt
Publikováno v:
eLife, Vol 9 (2020)
Genomic imprinting establishes parental allele-biased expression of a suite of mammalian genes based on parent-of-origin specific epigenetic marks. These marks are under the control of maternal effect proteins supplied in the oocyte. Here we report e
Externí odkaz:
https://doaj.org/article/e994c277b0c146169eb4f3f1fb17b649
Autor:
Stephen J. Clark, Ricard Argelaguet, Chantriolnt-Andreas Kapourani, Thomas M. Stubbs, Heather J. Lee, Celia Alda-Catalinas, Felix Krueger, Guido Sanguinetti, Gavin Kelsey, John C. Marioni, Oliver Stegle, Wolf Reik
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Relationships between DNA methylation and transcription, and methylation and DNA accessibility can be probed but interrogating all three in the same single cells has not been possible. Here, the authors report the first single-cell method for paralle
Externí odkaz:
https://doaj.org/article/ee5160af085446eb92ec31544e77c471
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-13 (2017)
Abstract Recent technological advances have enabled DNA methylation to be assayed at single-cell resolution. However, current protocols are limited by incomplete CpG coverage and hence methods to predict missing methylation states are critical to ena
Externí odkaz:
https://doaj.org/article/3e30c33c48cf401bac2d069724cc92a2