Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Heather A. Hundley"'
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background In all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide critical barriers to invasion and inducible expression of effectors that combat infection. The adenosine deami
Externí odkaz:
https://doaj.org/article/a704ed3a390c4da78923190a8ad2a70a
Autor:
Reshma Raghava Kurup, Eimile K. Oakes, Pranathi Vadlamani, Obi Nwosu, Pranav Danthi, Heather A. Hundley
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The RNA binding protein ADAR3 is expressed exclusively in the brain and reported to have elevated expression in tumors of patients suffering from glioblastoma compared to adjacent brain tissue. Yet, other studies have indicated that glioblas
Externí odkaz:
https://doaj.org/article/3a4015789ad5453d80b8ed6500a5fef5
Autor:
Michael C. Washburn, Boyko Kakaradov, Balaji Sundararaman, Emily Wheeler, Shawn Hoon, Gene W. Yeo, Heather A. Hundley
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 599-607 (2014)
Inadequate adenosine-to-inosine editing of noncoding regions occurs in disease but is often uncorrelated with ADAR levels, underscoring the need to study deaminase-independent control of editing. C. elegans have two ADAR proteins, ADR-2 and the theor
Externí odkaz:
https://doaj.org/article/41e2f6164f6b4788a9c7ae674b177067
Autor:
Berta Eliad, Noa Schneider, Orna Ben-Naim Zgayer, Yarden Amichan, Emily A. Erdmann, Heather A. Hundley, Ayelet T. Lamm
Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is a prevalent and conserved RNA modification. While A-to-I RNA editing is essential in mammals, inCaenorhabditis elegans, it is not, making them invaluable for RNA editing researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::869bd9fd6f2bc96e3927eda11a5dca20
https://doi.org/10.1101/2023.05.14.540679
https://doi.org/10.1101/2023.05.14.540679
Publikováno v:
bioRxiv
The ability to alter gene expression programs in response to changes in environmental conditions is central to the ability of an organism to thrive. For most organisms, the nervous system serves as the master regulator in communicating information ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8a62c88ae7d22ae649fa4fdd2b5517
https://doi.org/10.1101/2023.05.05.539519
https://doi.org/10.1101/2023.05.05.539519
BackgroundIn all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide critical barriers to invasion and inducible expression of effectors that combat infection. The adenosine deaminase that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38d6556cb8db32b7c006aaac660c1a0d
https://doi.org/10.1101/2023.05.03.539277
https://doi.org/10.1101/2023.05.03.539277
Autor:
Sarah N Deffit, Brian A Yee, Aidan C Manning, Suba Rajendren, Pranathi Vadlamani, Emily C Wheeler, Alain Domissy, Michael C Washburn, Gene W Yeo, Heather A Hundley
Publikováno v:
eLife, Vol 6 (2017)
ADAR proteins alter gene expression both by catalyzing adenosine (A) to inosine (I) RNA editing and binding to regulatory elements in target RNAs. Loss of ADARs affects neuronal function in all animals studied to date. Caenorhabditis elegans lacking
Externí odkaz:
https://doaj.org/article/0be709163d094d89ae3e71f8c13c24d9
Publikováno v:
Crit Rev Biochem Mol Biol
Adenosine deaminases that act on RNA (ADARs) are present in all animals and function to both bind double-stranded RNA (dsRNA) and catalyze the deamination of adenosine (A) to inosine (I). As inosine is a biological mimic of guanosine, deamination by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ee67318a56d72c573b2d6b34162107
https://doi.org/10.1080/10409238.2020.1856768
https://doi.org/10.1080/10409238.2020.1856768
Publikováno v:
Cell reports. 41(3)
Somatic adult stem cell lineages in high-turnover tissues are under tight gene regulatory control. Like its mammalian counterpart, the Drosophila intestine precisely adjusts the rate of stem cell division with the onset of differentiation based on ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e8079e5611e0766a7da32b6920f246
https://pubmed.ncbi.nlm.nih.gov/36261011
https://pubmed.ncbi.nlm.nih.gov/36261011
Publikováno v:
Genetics
The regulation of stem cell survival, self-renewal, and differentiation is critical for the maintenance of tissue homeostasis. Although the involvement of signaling pathways and transcriptional control mechanisms in stem cell regulation have been ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6e2afedc3d7e8a931de23b614b6d97
https://pubmed.ncbi.nlm.nih.gov/35762963
https://pubmed.ncbi.nlm.nih.gov/35762963