Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Heather A. Hirsch"'
Publikováno v:
Injury Epidemiology, Vol 5, Iss S1, Pp 23-29 (2018)
Abstract Background Sudden Unexpected Infant Death (SUID) results in 3400 sleep-related deaths yearly in the United States, yet caregivers’ compliance with safe sleep recommendations remains less than optimal. Paternal caregiver’s attitudes towar
Externí odkaz:
https://doaj.org/article/9b40453b31c7410cb5b70a1a06ba2f26
Autor:
Oliver Dorigo, Amit M. Oza, Tanja Pejovic, Prafull Ghatage, Sharad Ghamande, Diane Provencher, Lisa D. MacDonald, Heather Torrey, Valarmathy Kaliaperumal, Walead Ebrahimizadeh, Heather A. Hirsch, Yogesh Bramhecha, Jeannine Villella, Stephan Fiset
Publikováno v:
Clinical Cancer Research.
Purpose: Patients with platinum resistant ovarian cancer (OvCa) respond poorly to existing therapies. Hence there is a need for more effective treatments. Methods: The DeCidE1 trial is a multicenter, randomized, open-label, single-arm phase 2 study t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1f582f518dde062370107ff4852b658
https://doi.org/10.1158/1078-0432.ccr-22-2595
https://doi.org/10.1158/1078-0432.ccr-22-2595
Autor:
Stuart D. Shumway, D. Gary Gilliland, Stephen E. Fawell, Leigh Zawel, Carlo Toniatti, Yair Benita, Igor Feldman, Heather A. Hirsch, Brian Long, Alwin G. Schuller, Melissa S. Hurd, Yaping Liu, Jing Li, Amy D. Guertin
XLSX file - 155K, Proliferation assay EC50 results for MK-1775 in diverse tumor cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492fc6bcd867d365445a93212bebdc1b
https://doi.org/10.1158/1535-7163.22500334
https://doi.org/10.1158/1535-7163.22500334
Autor:
Elaine M. Pinheiro, Terrill K. McClanahan, Brian J. Long, Svetlana Sadekova, Razvan Cristescu, Andrey Loboda, Derek Y. Chiang, Lily Y. Moy, Aleksandra K. Olow, Sarah Javaid, Heather A. Hirsch, Kimberly S. Kerr, Wendy M. Blumenschein, Manjiri Sathe, Michael Nebozhyn, Venkataraman Sriram, Jennifer H. Yearley, Hui Xiao, Lan Chen, Michael Caniga, Selvakumar Sukumar, Douglas C. Wilson, Louise Cadzow, Mingmei Cai, Yun Wang, Marlene C. Hinton, Douglas E. Linn, Eric S. Muise, Peter Georgiev
Targeting the programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway with immunotherapy has revolutionized the treatment of many cancers. Somatic tumor mutational burden (TMB) and T-cell–inflamed gene expression profile (GEP) are clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdb5d08b628c9801815bfadb0bfe628
https://doi.org/10.1158/1535-7163.c.6543385.v1
https://doi.org/10.1158/1535-7163.c.6543385.v1
Autor:
Elaine M. Pinheiro, Terrill K. McClanahan, Brian J. Long, Svetlana Sadekova, Razvan Cristescu, Andrey Loboda, Derek Y. Chiang, Lily Y. Moy, Aleksandra K. Olow, Sarah Javaid, Heather A. Hirsch, Kimberly S. Kerr, Wendy M. Blumenschein, Manjiri Sathe, Michael Nebozhyn, Venkataraman Sriram, Jennifer H. Yearley, Hui Xiao, Lan Chen, Michael Caniga, Selvakumar Sukumar, Douglas C. Wilson, Louise Cadzow, Mingmei Cai, Yun Wang, Marlene C. Hinton, Douglas E. Linn, Eric S. Muise, Peter Georgiev
Supplementary Data from Reverse Translating Molecular Determinants of Anti–Programmed Death 1 Immunotherapy Response in Mouse Syngeneic Tumor Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681228ea71eeffe6a5d955b9c8768f68
https://doi.org/10.1158/1535-7163.22522450
https://doi.org/10.1158/1535-7163.22522450
Autor:
Stuart D. Shumway, D. Gary Gilliland, Stephen E. Fawell, Leigh Zawel, Carlo Toniatti, Yair Benita, Igor Feldman, Heather A. Hirsch, Brian Long, Alwin G. Schuller, Melissa S. Hurd, Yaping Liu, Jing Li, Amy D. Guertin
PDF file - 91K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a7cf7ca2ac141b60904c3102a52be3
https://doi.org/10.1158/1535-7163.22500340.v1
https://doi.org/10.1158/1535-7163.22500340.v1
Autor:
Stuart D. Shumway, D. Gary Gilliland, Stephen E. Fawell, Leigh Zawel, Carlo Toniatti, Yair Benita, Igor Feldman, Heather A. Hirsch, Brian Long, Alwin G. Schuller, Melissa S. Hurd, Yaping Liu, Jing Li, Amy D. Guertin
PDF file - 724K, S1. MK-1775 treatment inhibits proliferation in diverse tumor cell lines. S2. DNA damage induction by MK-1775 treatment requires mitogen stimulation. S3. The MK-1775 response of three sensitive cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d093e9b93e6fd5103c6d8d6164c9d19
https://doi.org/10.1158/1535-7163.22500337
https://doi.org/10.1158/1535-7163.22500337
Autor:
Stuart D. Shumway, D. Gary Gilliland, Stephen E. Fawell, Leigh Zawel, Carlo Toniatti, Yair Benita, Igor Feldman, Heather A. Hirsch, Brian Long, Alwin G. Schuller, Melissa S. Hurd, Yaping Liu, Jing Li, Amy D. Guertin
Inhibition of the DNA damage checkpoint kinase WEE1 potentiates genotoxic chemotherapies by abrogating cell-cycle arrest and proper DNA repair. However, WEE1 is also essential for unperturbed cell division in the absence of extrinsic insult. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234fe646475a388b8076dcd1eaf55c74
https://doi.org/10.1158/1535-7163.c.6536428.v1
https://doi.org/10.1158/1535-7163.c.6536428.v1
Metformin, the first-line drug for treating diabetes, selectively kills the chemotherapy resistant subpopulation of cancer stem cells (CSC) in genetically distinct types of breast cancer cell lines. In mouse xenografts, injection of metformin and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b12d7995a60504f4d456545879f05687
https://doi.org/10.1158/0008-5472.c.6502725.v1
https://doi.org/10.1158/0008-5472.c.6502725.v1
Autor:
Peter Georgiev, Eric S. Muise, Douglas E. Linn, Marlene C. Hinton, Yun Wang, Mingmei Cai, Louise Cadzow, Douglas C. Wilson, Selvakumar Sukumar, Michael Caniga, Lan Chen, Hui Xiao, Jennifer H. Yearley, Venkataraman Sriram, Michael Nebozhyn, Manjiri Sathe, Wendy M. Blumenschein, Kimberly S. Kerr, Heather A. Hirsch, Sarah Javaid, Aleksandra K. Olow, Lily Y. Moy, Derek Y. Chiang, Andrey Loboda, Razvan Cristescu, Svetlana Sadekova, Brian J. Long, Terrill K. McClanahan, Elaine M. Pinheiro
Publikováno v:
Molecular Cancer Therapeutics. 21:427-439
Targeting the programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway with immunotherapy has revolutionized the treatment of many cancers. Somatic tumor mutational burden (TMB) and T-cell–inflamed gene expression profile (GEP) are clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f195b533efd20f8c25094ce9564cd84c
https://doi.org/10.1158/1535-7163.mct-21-0561
https://doi.org/10.1158/1535-7163.mct-21-0561