Výsledky vyhledávání - "Heather A. Burgess"

Akademický článek

Front-Line Insights Into the Social Determinants of Health in Housing Instability: A Multi-Province Study

Autor: Ethan C. Draper, Heather J. Burgess, Cheryl Chisholm, Erin L. Mazerolle, Conor Barker

Publikováno v: Journal of Primary Care & Community Health, Vol 15 (2024)

Introduction: Individuals experiencing housing instability face significant health inequities. Addressing housing instability requires an understanding of the factors that contribute to these inequities—a responsibility that has been assumed by com

Externí odkaz: https://doaj.org/article/5da09eada901413aaac772b62a2c482f

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The importance of mentorship and collaboration for scientific capacity-building and capacity-sharing: perspectives of African scientists

Autor: Joanna Chataway, Heather E. Burgess

Publikováno v: F1000Research. 10:164

Long-term goals for capacity-building in Africa centres around building a self-sufficient scientific community, however there is a lack of research on the interactions that are needed to make up a thriving academic community or the steps needed to re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8407990fb64625a49a70c49930699dea
https://doi.org/10.12688/f1000research.50937.1

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In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine

Autor: Wolf Reik, Shankar Balasubramanian, Eun-Ang Raiber, Wendy Dean, Dario Beraldi, Heather E. Burgess, Mario Iurlaro, Martin Bachman, Gordon R. McInroy

Publikováno v: Genome Biology

Background Genome-wide methylation of cytosine can be modulated in the presence of TET and thymine DNA glycosylase (TDG) enzymes. TET is able to oxidise 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f507d255e98a16ef807293046092160
http://europepmc.org/articles/PMC4928330

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5-Formylcytosine can be a stable DNA modification in mammals

Autor: Santiago Uribe-Lewis, Adele Murrell, Martin Bachman, Heather E. Burgess, Mario Iurlaro, Wolf Reik, Shankar Balasubramanian, Xiaoping Yang

Publikováno v: Bachman, M, Uribe-Lewis, S, Yang, X, Burgess, H E, Iurlaro, M, Reik, W, Murrell, A & Balasubramanian, S 2015, ' 5-Formylcytosine can be a stable DNA modification in mammals ', Nature Chemical Biology, vol. 11, no. 8, pp. 555-557 . https://doi.org/10.1038/nchembio.1848

5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b836e103613bdc2ed7e744f3a6569e30
https://purehost.bath.ac.uk/ws/files/123960873/NCHEMBIO_1848_Final_ED_2_.pdf

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Active demethylation in mouse zygotes involves cytosine deamination and base excision repair

Autor: Wolf Reik, Cristina Rada, Heather E. Burgess, Julian R. Peat, Wendy Dean, Fátima Santos

Publikováno v: Epigenetics & Chromatin

Background DNA methylation in mammals is an epigenetic mark necessary for normal embryogenesis. During development active loss of methylation occurs in the male pronucleus during the first cell cycle after fertilisation. This is accompanied by major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82a2a654c2dbef2e1b5133918435c83
https://doi.org/10.1186/1756-8935-6-39

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PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis

Autor: Heather F. Lakatos, Louis Eugene Daugherty, Thomas H. Thatcher, Richard P. Phipps, Michelle R Redonnet, Patricia J. Sime, Denise M. Ray, Heather A. Burgess

Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 288(6)

Pulmonary fibrosis is a progressive life-threatening disease for which no effective therapy exists. Myofibroblasts are one of the key effector cells in pulmonary fibrosis and are the primary source of extracellular matrix production. Drugs that inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e4e76be7b3117efe5c35ada45efe29
https://pubmed.ncbi.nlm.nih.gov/15734787

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