Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Heather A. Arnett"'
Autor:
Daniel Lu, Tracy Yamawaki, Hong Zhou, Wen-Yu Chou, Mark Chhoa, Edwin Lamas, Sabine S Escobar, Heather A Arnett, Huanying Ge, Todd Juan, Songli Wang, Chi-Ming Li
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214296 (2019)
Monocytes are a distinct subset of myeloid cells with diverse functions in early inflammatory immune modulation. While previous studies have surveyed the role of miRNA regulation on different myeloid cell lines and primary cultures, the time-dependen
Externí odkaz:
https://doaj.org/article/9151e50da9f246fba9cb80ad5e5b209a
Autor:
Xiting Yan, Qiaonan Duan, Ehab A. Ayaub, George R. Washko, Heather A. Arnett, Benjamin A. Raby, Farida Ahangari, Nir Neumark, Jonas C. Schupp, Giuseppe DeIuliis, Asim Siddiqui, Taylor Adams, Michael Januszyk, Robert J. Homer, Sergio Poli, Ivan O. Rosas, Naftali Kaminski, Sarah G. Chu
Publikováno v:
Science Advances
Human lung single-cell atlas reveals the complexity and diversity of aberrant cellular populations in pulmonary fibrosis.
We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, by profiling 312,
We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, by profiling 312,
Autor:
Taylor Adams, Sergio Poli, Jonas C. Schupp, Naftali Kaminski, Ehab A. Ayaub, Asim Siddiqui, Sarah G. Chu, Ivan O. Rosas, Giuseppe DeIuliis, Heather A. Arnett, Benjamin A. Raby, George R. Washko, Farida Ahangari, Nir Neumark, Qiaonan Duan, Xiting Yan, Michael Januszyk, Robert J. Homer
We provide a single cell atlas of Idiopathic Pulmonary Fibrosis (IPF), a fatal interstitial lung disease, focusing on resident lung cell populations. By profiling 312,928 cells from 32 IPF, 29 healthy control and 18 chronic obstructive pulmonary dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce4d324e1f1461d304f8f1be3d757db
https://doi.org/10.1101/759902
https://doi.org/10.1101/759902
Autor:
Jennifer E. Towne, Gaby Palmer, Cem Gabay, Vincent Flacher, Praxedis Martin, Nicolò Costantino Brembilla, Yu Sun, David Jarrossay, Damien Dietrich, Heather A. Arnett, Christopher G. Mueller
Publikováno v:
Cytokine, Vol. 84 (2016) pp. 88-98
Cytokine
Cytokine, Elsevier, 2016, 84, pp.88-98. ⟨10.1016/j.cyto.2016.05.012⟩
Cytokine
Cytokine, Elsevier, 2016, 84, pp.88-98. ⟨10.1016/j.cyto.2016.05.012⟩
Interleukin (IL)-36 cytokines belong to the IL-1 family and include three agonists, IL-36 α, β and γ and one inhibitor, IL-36 receptor antagonist (IL-36Ra). IL-36 and IL-1 (α and β) activate similar intracellular pathways via their related heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdc4fa215851bbb1eb201afbd0b1f64
https://archive-ouverte.unige.ch/unige:99457
https://archive-ouverte.unige.ch/unige:99457
Publikováno v:
Journal of Paleolimnology. 47:277-291
Atmospheric deposition of reactive nitrogen (Nr) has enriched oligotrophic lakes with nitrogen (N) in many regions of the world and elicited dramatic changes in diatom community structure. The lakewater concentrations of nitrate that cause these comm
Autor:
Kelvin K. C. Sham, Lewis D. Pennington, Paul E. Harrington, Matthew R. Lee, Michele McElvain, Xuxia Zhang, Heather A. Arnett, Min Wong, Alexander J. Pickrell, Anthony B. Reed, Henry Morrison, Victor J. Cee, Mike Fiorino, Christopher H. Fotsch, Michael J. Frohn, Yang Xu, Michael Croghan, Han Xu, Brian A. Lanman, Andrew Tasker, Michelle Horner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:527-531
We reveal how a N-scan SAR strategy (systematic substitution of each CH group with a N atom) was employed for quinolinone-based S1P(1) agonist 5 to modulate physicochemical properties and optimize in vitro and in vivo activity. The diaza-analog 17 di
Autor:
Michael Croghan, Andrew Tasker, Matthew R. Lee, Xuxia Zhang, Heather A. Arnett, Victor J. Cee, Anthony B. Reed, Kelvin K. C. Sham, Michele McElvain, Henry Morrison, Alexander J. Pickrell, Lewis D. Pennington, Mike Frohn, Yang Xu, Paul E. Harrington, Min Wong, Han Xu, Brian A. Lanman, Mike Fiorino, Christopher H. Fotsch
Publikováno v:
ACS Medicinal Chemistry Letters. 3:74-78
The optimization of a series of S1P1 agonists with limited activity against S1P3 is reported. A polar headgroup was used to improve the physicochemical and pharmacokinetic parameters of lead quinolinone 6. When dosed orally at 1 and 3 mg/kg, the azah
Autor:
Min Wong, Heather A. Arnett, Michael Croghan, Michele McElvain, Yang Xu, Xuxia Zhang, Matthew R. Lee, Lewis D. Pennington, Paul E. Harrington, Henry Morrison, Victor J. Cee, Anthony B. Reed, Michael J. Frohn, Alexander J. Pickrell, Mike Fiorino, Kelvin K. C. Sham, Han Xu, Brian A. Lanman, Christopher H. Fotsch, Michelle Horner
Publikováno v:
ACS Medicinal Chemistry Letters. 2:752-757
The sphingosine-1-phosphate-1 receptor (S1P1) and its endogenous ligand sphingosine-1-phosphate (S1P) cooperatively regulate lymphocyte trafficking from the lymphatic system. Herein, we disclose 4-methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]
Autor:
Min Wong, Yang Xu, Scot Middleton, Matthew R. Lee, Anu Gore, Mike Fiorino, Alex Pickrell, Kristine M. Muller, Andrea Itano, Mike Frohn, Heather A. Arnett, Janet Buys, Michelle Horner, Dalia Rivenzon-Segal, Jennifer E. Golden, Victor J. Cee, Hugo M. Vargas, Roland Burli, Susana C. Neira, Michael Schrag, Han Xu, Brian A. Lanman, Michele McElvain, Xuxia Zhang, Jerry Siu
Publikováno v:
ACS Medicinal Chemistry Letters. 2:107-112
The optimization of a series of thiazolopyridine S1P1 agonists with limited activity at the S1P3 receptor is reported. These efforts resulted in the discovery of 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo-[5,4-b]pyridin-2-yl)benzyl)azetidine-3-ca
Autor:
Alexander P. Wolfe, Jasmine E. Saros, Craig E. Williamson, Anijrea B. Nurse, Heather A. Arnett, Kevin C. Rose, Jeffery R. Stone, David W. Clow, Verlin C. Stephens
Publikováno v:
Environmental Science & Technology. 44:4891-4896
Alpine glaciers have receded substantially over the last century in many regions of the world. Resulting changes in glacial runoff not only affect the hydrological cycle, but can also alter the physical (i.e., turbidity from glacial flour) and biogeo