Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Heather A Pilch-Cooper"'
Autor:
Gareth A D Hardy, Scott Sieg, Benigno Rodriguez, Donald Anthony, Robert Asaad, Wei Jiang, Joseph Mudd, Timothy Schacker, Nicholas T Funderburg, Heather A Pilch-Cooper, Robert Debernardo, Ronald L Rabin, Michael M Lederman, Clifford V Harding
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56527 (2013)
Type-I interferon (IFN-I) has been increasingly implicated in HIV-1 pathogenesis. Various studies have shown elevated IFN-I and an IFN-I-induced gene and protein expression signature in HIV-1 infection, yet the elevated IFN-I species has not been con
Externí odkaz:
https://doaj.org/article/3a23dd781f5f4bdea6d4d2dae304b4e5
Autor:
Nicholas T Funderburg, Adriana Andrade, Ellen S Chan, Susan L Rosenkranz, Darlene Lu, Brian Clagett, Heather A Pilch-Cooper, Benigno Rodriguez, Judith Feinberg, Eric Daar, John Mellors, Daniel Kuritzkes, Jeffrey M Jacobson, Michael M Lederman
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83514 (2013)
The dynamics of CD4+ T cell reconstitution and changes in immune activation and inflammation in HIV-1 disease following initiation of antiretroviral therapy (ART) are incompletely defined and their underlying mechanisms poorly understood.Thirty-nine
Externí odkaz:
https://doaj.org/article/3b58f04f006740d5be4622a96fcb8721
Autor:
Scott Howell, Young Soo Park, Alan D. Levine, Heather A. Pilch-Cooper, Angélica Cruz-Lebrón, Marie R. McCausland, Jeffrey M. Albert
Publikováno v:
AIDS
DESIGN Since intestinal immunity and the microbiome are disrupted in HIV disease, we studied the abundance of innate immune sensors, Toll-like receptors (TLRs), in the mucosa of participants with viremia, prior to antiretroviral therapy (ART), immune
Autor:
Ronald S. Veazey, Michael M. Lederman, Ann M. Carias, Heather A. Pilch-Cooper, Galit Alter, Peter Wilkinson, Scott F. Sieg, Adrian Reich, Xiaolei Wang, Benigno Rodriguez, Magdalena Sips, Mark J. Cameron, Thomas J. Hope
Publikováno v:
Mucosal immunology
Understanding vaginal and rectal HIV transmission and protective cellular and molecular mechanisms is critical for designing new prevention strategies, including those required for an effective vaccine. The determinants of protection against HIV infe
Autor:
Julie K. Jadlowsky, Ronald S. Veazey, Heather A. Pilch-Cooper, Thomas J. Hope, Mark R. Chance, Brian Clagett, Ronald G. Collman, Kathy Medvik, Valentina Mercanti, Nadeene E. Riddick, Michael M. Lederman, James A. Hoxie, Jean-Michel Escola, Scott F. Sieg, Ann Koons, Oliver Hartley, Donald E. Mosier, Robin E. Offord, Janna Kiselar
Publikováno v:
Blood, Vol. 118, No 4 (2011) pp. 1015-9
Blood
Blood
CC Chemokine Receptor 5 (CCR5) is an important mediator of chemotaxis and the primary coreceptor for HIV-1. A recent report by other researchers suggested that primary T cells harbor pools of intracellular CCR5. With the use of a series of complement
Autor:
Grace A. McComsey, Steven Juchnowski, Shawn Rose, Brian Clagett, Michael M. Lederman, Brian Ferrari, David A. Zidar, Nicholas T. Funderburg, Nehal N. Mehta, Scott F. Sieg, Benigno Rodriguez, Heather A. Pilch-Cooper
BACKGROUND HIV infection is associated with increased cardiovascular risk, and this risk correlates with markers of monocyte activation. We have shown that HIV is associated with a prothrombotic monocyte phenotype, which can be partially mitigated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ced29fae1b557465ea59eba58d92ff
https://europepmc.org/articles/PMC4446174/
https://europepmc.org/articles/PMC4446174/
Autor:
Nicholas T. Funderburg, Carey L. Shive, Benigno Rodriguez, Scott F. Sieg, Heather A. Pilch-Cooper, Leonid Margolis, Hernan Valdez, Grace A. McComsey, Michael M. Lederman, Angelique Biancotto
Publikováno v:
Journal of acquired immune deficiency syndromes (1999). 61(2)
OBJECTIVE Increased plasma IL-6 levels have been associated with HIV-1 disease progression risk, yet the drivers of IL-6 production in HIV-1 infection are not known. This study was designed to explore the relationship between HIV-1 replication and IL
Autor:
Robert Debernardo, Scott F. Sieg, Wei Jiang, Donald D. Anthony, Robert Asaad, Gareth Hardy, Joseph C. Mudd, Nicholas T. Funderburg, Timothy W. Schacker, Clifford V. Harding, Benigno Rodriguez, Ronald L. Rabin, Michael M. Lederman, Heather A. Pilch-Cooper
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56527 (2013)
PLoS ONE
PLoS ONE
Type-I interferon (IFN-I) has been increasingly implicated in HIV-1 pathogenesis. Various studies have shown elevated IFN-I and an IFN-I-induced gene and protein expression signature in HIV-1 infection, yet the elevated IFN-I species has not been con
Autor:
Valentina Mercanti, Thomas J. Hope, Robin E. Offord, Ronald G. Collman, Oliver Hartley, Julie K. Jadlowsky, Brian Clagett, Ronald S. Veazey, Scott F. Sieg, Mark R. Chance, Michael M. Lederman, Nadeene E. Riddick, Heather A. Pilch-Cooper, Donald E. Mosier
Publikováno v:
Blood. 118:1179-1179
Guglielmi et al report that a minority (15%) of circulating CD4+ T cells show intracellular staining with a murine monoclonal antibody, 2D7, which recognizes a domain on the second extracellular loop of CCR5. They find that this staining is not seen
Autor:
Heather A. Pilch-Cooper, Michael M. Lederman, Robin L.P. Jump, Scott F. Sieg, Michael J. Root
Publikováno v:
Retrovirology, Vol 5, Iss 1, p 116 (2008)
Retrovirology
Retrovirology
With the continuing march of the AIDS epidemic and little hope for an effective vaccine in the near future, work to develop a topical strategy to prevent HIV infection is increasingly important. This stated, the track record of large scale "microbici