Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Heather A Ferris"'
Autor:
E Nicholas Petersen, Mahmud Arif Pavel, Samuel S Hansen, Manasa Gudheti, Hao Wang, Zixuan Yuan, Keith R Murphy, William Ja, Heather A Ferris, Erik Jorgensen, Scott B Hansen
Publikováno v:
eLife, Vol 12 (2024)
Rapid conversion of force into a biological signal enables living cells to respond to mechanical forces in their environment. The force is believed to initially affect the plasma membrane and then alter the behavior of membrane proteins. Phospholipas
Externí odkaz:
https://doaj.org/article/cca19ceafd0f4bda82ed3c895c620453
Publikováno v:
PLoS Biology, Vol 11, Iss 4, p e1001532 (2013)
The sterol sensor SCAP is a key regulator of SREBP-2, the major transcription factor controlling cholesterol synthesis. Recently, we showed that there is a global down-regulation of cholesterol synthetic genes, as well as SREBP-2, in the brains of di
Externí odkaz:
https://doaj.org/article/20626864efbe41f48c6aed40649860c6
Autor:
Andrés Norambuena, Xuehan Sun, Horst Wallrabe, Ruofan Cao, Naidi Sun, Evelyn Pardo, Nutan Shivange, Dora Bigler Wang, Lisa A. Post, Heather A. Ferris, Song Hu, Ammasi Periasamy, George S. Bloom
Publikováno v:
Neurobiology of Disease, Vol 169, Iss , Pp 105737- (2022)
Altered mitochondrial DNA (mtDNA) occurs in neurodegenerative disorders like Alzheimer's disease (AD); how mtDNA synthesis is linked to neurodegeneration is poorly understood. We previously discovered Nutrient-induced Mitochondrial Activity (NiMA), a
Externí odkaz:
https://doaj.org/article/0571f575ba894236ad90237fcfccbe8e
Autor:
André Kleinridders, Heather A. Ferris, Michelle L. Reyzer, Michaela Rath, Marion Soto, M. Lisa Manier, Jeffrey Spraggins, Zhihong Yang, Robert C. Stanton, Richard M. Caprioli, C. Ronald Kahn
Publikováno v:
Molecular Metabolism, Vol 12, Iss , Pp 113-121 (2018)
Objective: Glucose is the major energy substrate of the brain and crucial for normal brain function. In diabetes, the brain is subject to episodes of hypo- and hyperglycemia resulting in acute outcomes ranging from confusion to seizures, while chroni
Externí odkaz:
https://doaj.org/article/e3b3bf9b3ec147769c0344d2c9e1cbb6
Publikováno v:
bioRxiv
Circadian symptoms have long been observed in Alzheimer’s disease (AD) and often appear before cognitive symptoms, but the mechanisms underlying circadian alterations in AD are poorly understood. We studied circadian re-entrainment in AD model mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3e9d4330d09ff4eb325ee92e7d7ada
https://doi.org/10.1101/2023.05.02.539086
https://doi.org/10.1101/2023.05.02.539086
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/14c5021ca79844c7a1834fd3970d5215
Autor:
Hao Wang, Joshua A. Kulas, Holden Higginbotham, Michael A. Kovacs, Heather A. Ferris, Scott B. Hansen
Neurodegeneration and its concomitant loss of cognitive function is associated with inflammation and an accumulation of lipids, in particular cholesterol. In the brain, cholesterol is made in astrocytes and transported to surrounding cells by apolipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b75452935230c630304b91984e7242c4
https://doi.org/10.1101/2022.12.12.520161
https://doi.org/10.1101/2022.12.12.520161
Autor:
Ku-Lung Hsu, Heather A. Ferris, Jeffrey W. Brulet, Mitchell E. Granade, Thurl E. Harris, Tao Huang, Seyyedmohsen Hosseinibarkooie, Adam L. Borne
Publikováno v:
Chemical Science
Sulfonyl-triazoles are a new class of electrophiles that mediate covalent reaction with tyrosine residues on proteins through sulfur-triazole exchange (SuTEx) chemistry. Recent studies demonstrate the broad utility and tunability of SuTEx chemistry f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf7e33426ec572ae52cc64d0e7dc2ed
https://doi.org/10.1039/d0sc06623k
https://doi.org/10.1039/d0sc06623k
Publikováno v:
Drug Dev Res
Diabetes disrupts organs throughout the body including the brain. Evidence suggests diabetes is a risk factor for Alzheimer's disease (AD) and neurodegeneration. In this review, we focus on understanding how diabetes contributes to the progression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1241ae2f46bcc8643d49dffd773d26c2
https://doi.org/10.1002/ddr.21643
https://doi.org/10.1002/ddr.21643
Autor:
Joshua L. Milstein, Heather A. Ferris
Publikováno v:
Molecular Metabolism, Vol 52, Iss, Pp 101234-(2021)
Molecular Metabolism
Molecular Metabolism
Background The brain was once thought of as an insulin-insensitive organ. We now know that the insulin receptor is present throughout the brain and serves important functions in whole-body metabolism and brain function. Brain insulin signaling is inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d58c02c799894230e9fff5edb5587b
http://www.sciencedirect.com/science/article/pii/S221287782100079X
http://www.sciencedirect.com/science/article/pii/S221287782100079X