Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Heather A Ferris"'
Autor:
Jordan N. Reed, Faten Hasan, Abhishek Karkar, Dhanush Banka, Jameson Hinkle, Preeti Shastri, Navya Srivastava, Steven C. Scherping, Sarah E. Newkirk, Heather A. Ferris, Bijoy K. Kundu, Sibylle Kranz, Mete Civelek, Susanna R. Keller
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111323- (2024)
Summary: In humans, dietary patterns impact weight and metabolism differentially across individuals. To uncover genetic determinants for differential dietary effects, we subjected four genetically diverse mouse strains to humanized diets (American, M
Externí odkaz:
https://doaj.org/article/7ed07bee20334d349e393cd8d8a3aa49
Autor:
Lisa A. Post, Joshua A. Kulas, Joshua L. Milstein, Sarah V. L. Sebastian, Seyyedmohsen Hosseini-Barkooie, Max E. Stevenson, George S. Bloom, Heather A. Ferris
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract While historically viewed as an insulin insensitive organ, it is now accepted that insulin has a role in brain physiology. Changes in brain insulin and IGF1 signaling have been associated with neurological diseases, however the molecular fac
Externí odkaz:
https://doaj.org/article/f1aaef2f449c46ba99d160a3b2b7f049
Autor:
E Nicholas Petersen, Mahmud Arif Pavel, Samuel S Hansen, Manasa Gudheti, Hao Wang, Zixuan Yuan, Keith R Murphy, William Ja, Heather A Ferris, Erik Jorgensen, Scott B Hansen
Publikováno v:
eLife, Vol 12 (2024)
Rapid conversion of force into a biological signal enables living cells to respond to mechanical forces in their environment. The force is believed to initially affect the plasma membrane and then alter the behavior of membrane proteins. Phospholipas
Externí odkaz:
https://doaj.org/article/cca19ceafd0f4bda82ed3c895c620453
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Circadian symptoms have long been observed in Alzheimer’s disease (AD) and often appear before cognitive symptoms, but the mechanisms underlying circadian alterations in AD are poorly understood. We studied circadian re-entrainment in AD model mice
Externí odkaz:
https://doaj.org/article/b9064b65668041f683a754bd796310d8
Autor:
Andrés Norambuena, Xuehan Sun, Horst Wallrabe, Ruofan Cao, Naidi Sun, Evelyn Pardo, Nutan Shivange, Dora Bigler Wang, Lisa A. Post, Heather A. Ferris, Song Hu, Ammasi Periasamy, George S. Bloom
Publikováno v:
Neurobiology of Disease, Vol 169, Iss , Pp 105737- (2022)
Altered mitochondrial DNA (mtDNA) occurs in neurodegenerative disorders like Alzheimer's disease (AD); how mtDNA synthesis is linked to neurodegeneration is poorly understood. We previously discovered Nutrient-induced Mitochondrial Activity (NiMA), a
Externí odkaz:
https://doaj.org/article/0571f575ba894236ad90237fcfccbe8e
Autor:
Joshua L. Milstein, Heather A. Ferris
Publikováno v:
Molecular Metabolism, Vol 52, Iss , Pp 101234- (2021)
Background: The brain was once thought of as an insulin-insensitive organ. We now know that the insulin receptor is present throughout the brain and serves important functions in whole-body metabolism and brain function. Brain insulin signaling is in
Externí odkaz:
https://doaj.org/article/8a883d3d22e14261938274aff05a741e
Autor:
André Kleinridders, Heather A. Ferris, Michelle L. Reyzer, Michaela Rath, Marion Soto, M. Lisa Manier, Jeffrey Spraggins, Zhihong Yang, Robert C. Stanton, Richard M. Caprioli, C. Ronald Kahn
Publikováno v:
Molecular Metabolism, Vol 12, Iss , Pp 113-121 (2018)
Objective: Glucose is the major energy substrate of the brain and crucial for normal brain function. In diabetes, the brain is subject to episodes of hypo- and hyperglycemia resulting in acute outcomes ranging from confusion to seizures, while chroni
Externí odkaz:
https://doaj.org/article/e3b3bf9b3ec147769c0344d2c9e1cbb6
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/14c5021ca79844c7a1834fd3970d5215
Autor:
Hao Wang, Joshua A. Kulas, Holden Higginbotham, Michael A. Kovacs, Heather A. Ferris, Scott B. Hansen
Neurodegeneration and its concomitant loss of cognitive function is associated with inflammation and an accumulation of lipids, in particular cholesterol. In the brain, cholesterol is made in astrocytes and transported to surrounding cells by apolipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b75452935230c630304b91984e7242c4
https://doi.org/10.1101/2022.12.12.520161
https://doi.org/10.1101/2022.12.12.520161
Autor:
Ku-Lung Hsu, Heather A. Ferris, Jeffrey W. Brulet, Mitchell E. Granade, Thurl E. Harris, Tao Huang, Seyyedmohsen Hosseinibarkooie, Adam L. Borne
Publikováno v:
Chemical Science
Sulfonyl-triazoles are a new class of electrophiles that mediate covalent reaction with tyrosine residues on proteins through sulfur-triazole exchange (SuTEx) chemistry. Recent studies demonstrate the broad utility and tunability of SuTEx chemistry f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf7e33426ec572ae52cc64d0e7dc2ed
https://doi.org/10.1039/d0sc06623k
https://doi.org/10.1039/d0sc06623k