Výsledky vyhledávání - "Heather A Brauer"

Akademický článek

Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation.

Autor: Brante P Sampey, Alex J Freemerman, Jimmy Zhang, Pei-Fen Kuan, Joseph A Galanko, Thomas M O'Connell, Olga R Ilkayeva, Michael J Muehlbauer, Robert D Stevens, Christopher B Newgard, Heather A Brauer, Melissa A Troester, Liza Makowski

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38812 (2012)

Obesity has reached epidemic proportions worldwide. Several animal models of obesity exist, but studies are lacking that compare traditional lard-based high fat diets (HFD) to "Cafeteria diets" (CAF) consisting of nutrient poor human junk food. Our p

Externí odkaz: https://doaj.org/article/8123c07fdc0d45b6ac1702b037a95c4d

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Akademický článek

Distinct spatial immune microlandscapes are independently associated with outcomes in triple-negative breast cancer

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract The utility of spatial immunobiomarker quantitation in prognostication and therapeutic prediction is actively being investigated in triple-negative breast cancer (TNBC). Here, with high-plex quantitative digital spatial profiling, we map and

Externí odkaz: https://doaj.org/article/d5560e60b96445c4af2242dfe42eae7f

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Akademický článek

Adaptive immune signature in HER2-positive breast cancer in NCCTG (Alliance) N9831 and NeoALTTO trials

Publikováno v: npj Breast Cancer, Vol 8, Iss 1, Pp 1-8 (2022)

Abstract Trastuzumab acts in part through the adaptive immune system. Previous studies showed that enrichment of immune-related gene expression was associated with improved outcomes in HER2-positive (HER2+) breast cancer. However, the role of the imm

Externí odkaz: https://doaj.org/article/c541e25cb1954a448e8d1d99ad81395d

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Akademický článek

Phase I clinical trial of the combination of eribulin and everolimus in patients with metastatic triple-negative breast cancer

Autor: Jin Sun Lee, Susan E. Yost, Suzette Blanchard, Daniel Schmolze, Hongwei Holly Yin, Raju Pillai, Kim Robinson, Aileen Tang, Norma Martinez, Jana Portnow, Wei Wen, John H. Yim, Heather Ann Brauer, Yuqi Ren, Thehang Luu, Joanne Mortimer, Yuan Yuan

Publikováno v: Breast Cancer Research, Vol 21, Iss 1, Pp 1-13 (2019)

Abstract Background Alteration of the PI3K/AKT/mTOR pathway is a common genomic abnormality detected in triple-negative breast cancer (TNBC). Everolimus acts synergistically with eribulin in TNBC cell lines and xenograft models. This phase I trial wa

Externí odkaz: https://doaj.org/article/7dd4eead50f74df9b8ddd632d9e2509e

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Data from NSABP B-41, a Randomized Neoadjuvant Trial: Genes and Signatures Associated with Pathologic Complete Response

Autor: Norman Wolmark, Eleftherios P. Mamounas, Priya Rastogi, Charles E. Geyer, Yuqi Ren, Hanna Bandos, Brent T. Harris, André Robidoux, Peter C. Lucas, David S. Goerlitz, Heather Ann Brauer, Gong Tang, Sandra M. Swain

Purpose:In NSABP B-41, pathologic complete response (pCR) was associated with prolonged survival among women with HER2-positive operable breast cancer treated with neoadjuvant chemotherapy and lapatinib, trastuzumab, or the combination. We used a lar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d14083713abc30c84440afa08aa7e55
https://doi.org/10.1158/1078-0432.c.6529788.v1

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Supplementary Tables S1-S6 from Predictive Biomarkers for Adjuvant Capecitabine Benefit in Early-Stage Triple-Negative Breast Cancer in the FinXX Clinical Trial

Autor: Saranya Chumsri, E. Aubrey Thompson, Heikki Joensuu, Torsten O. Nielsen, Henrik Lindman, Susanna Lauttia, Amy Sullivan, Heather Ann Brauer, Karama Asleh

Supplementary Table S1 includes biological description of the 30 custom genes, Supplementary Tables S2-S3 show patient characteristics, Supplementary Table S4 shows biological classification of the study cohort, Supplementary Tables S5-6 show surviva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae702e63ec15581a6480b082486419b
https://doi.org/10.1158/1078-0432.22478987.v1

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Supplementary Figure 1 from Impact of Tumor Microenvironment and Epithelial Phenotypes on Metabolism in Breast Cancer

Autor: Melissa A. Troester, Charles M. Perou, Alex J. Freemerman, Monica D'Arcy, Erick Romàn-Pèrez, Lindsay J. Lang, Patricia Casbas-Hernandez, Katherine A. Hoadley, Liza Makowski, Heather Ann Brauer

PDF file - 102K, Glucose metabolism is elevated in basal-like breast cancer with lactate production increasing with stroma presence. Glucose uptake, oxidation, and glycogen synthesis in increased in breast cancer cells (MCF7 and SUM149) when compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd6f8c0ca610fdec27ca1086843c00e
https://doi.org/10.1158/1078-0432.22451507

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