Recruitment and Screening for a Randomized Trial Investigating Roux-en-Y Gastric Bypass versus Intensive Medical Management for Treatment of Type 2 Diabetes

Autor: Heather A. Bainbridge, Judith Korner, Shu Chun Chen, Avis J. Thomas, Joyce L. Schone, John E. Connett, Wei-Jei Lee, Sayeed Ikramuddin, Michael D. Jensen, Daniel B. Leslie

Publikováno v: Obesity Surgery. 24:1875-1880

Large-scale randomized clinical trials are needed to assess the role of Roux-en-Y gastric bypass (RYGB) in treating patients with type 2 diabetes mellitus (T2DM). Recruitment challenges must be understood.One hundred twenty participants were needed f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18414f417c16b040cdcb3728232a697
https://doi.org/10.1007/s11695-014-1280-4

Evaluation of CSF and plasma biomarkers of brain melanocortin activity in response to caloric restriction in humans

Autor: Kim T. Nguyen, Richard M. Smiley, Judith Korner, Sunil K Panigrahi, Sharon L. Wardlaw, Heather A. Bainbridge, Deniz Atalayer, Anne White, Gabrielle Page-Wilson, Rebecca J Gordon, Kana Meece

Publikováno v: Page-Wilson, G, Nguyen-Thi, K T, Atalayer, D, Meece, K, Bainbridge, H A, Korner, J, Gordon, R J, Panigrahi, S K, White, A, Smiley, R & Wardlaw, S L 2017, ' Evaluation of CSF and plasma biomarkers of brain melanocortin activity in response to caloric restriction in humans ', American Journal of Physiology: Endocrinology and Metabolism
, vol. 312, pp. E19-E26 . https://doi.org/10.1152/ajpendo.00330.2016

The melanocortin neuronal system, which consists of hypothalamic proopiomelanocortin (POMC) and agouti-related protein (AgRP) neurons, is a leptin target that regulates energy balance and metabolism, but studies in humans are limited by a lack of rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e273922b27cb1a152c341b3fb2e096
https://pubmed.ncbi.nlm.nih.gov/27894065

Roux-en-Y gastric bypass for diabetes (the Diabetes Surgery Study): 2-year outcomes of a 5-year, randomised, controlled trial

Autor: Charles J. Billington, Kumar G. Belani, Lee-Ming Chuang, William B. Inabnet, Heather A. Bainbridge, Adrian Vella, Judith Korner, John P. Bantle, Michael D. Jensen, Avis J. Thomas, Amy Olofson, Patricia S. Laqua, Keong Chong, Qi Wang, Robert W. Jeffery, Wei Jei Lee, Leaque Ahmed, Joyce L. Schone, Daniel B. Leslie, John E. Connett, Michael G. Sarr, Sayeed Ikramuddin

Publikováno v: The lancet. Diabetesendocrinology. 3(6)

Summary Background Conventional treatments for patients with type 2 diabetes are often inadequate. We aimed to assess outcomes of diabetes control and treatment risks 2 years after adding Roux-en-Y gastric bypass to intensive lifestyle and medical ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106c82bd7c8969a1bf06c53f25949347
https://pubmed.ncbi.nlm.nih.gov/25979363

National Differences in Remission of Type 2 Diabetes Mellitus After Roux-en-Y Gastric Bypass Surgery-Subgroup Analysis of 2-Year Results of the Diabetes Surgery Study Comparing Taiwanese with Americans with Mild Obesity (BMI 30–35 kg/m2)

Autor: Amy Olofson, Charles J. Billington, Avis J. Thomas, Qi Wang, Judith Korner, Wei-Jei Lee, Kumar G. Belani, William B. Inabnet, John P. Bantle, Sayeed Ikramuddin, Lee-Ming Chuang, Keong Chong, Daniel B. Leslie, Joyce L. Schone, Michael D. Jensen, Patricia S. Laqua, Leaque Ahmed, John E. Connett, Michael G. Sarr, Adrian Vella, Heather A. Bainbridge, Robert W. Jeffery

Publikováno v: Obesity Surgery. 27(5):1189-1195

The purpose of this study is to compare effects of different nations on Roux-en-Y gastric bypass (RYGB) vs. intensive medical management (IMM) in achieving remission of type 2 diabetes mellitus (T2DM). Between April 2008 and December 2011, this rando

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5dcc3afcbc5d17217c7c7e753e1141