Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Heather, Giles"'
Publikováno v:
The Korean Journal of Pain
Background Management of pain from open wounds is a growing unmet healthcare need. However, the models available to study pain from wounds or to develop analgesics for the patients suffering from them have primarily relied on incisional models. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62dfc22180b6504c6772e3e6e1e8ffc6
https://doi.org/10.3344/kjp.2021.34.2.165
https://doi.org/10.3344/kjp.2021.34.2.165
Autor:
Heather Giles, Richard A. Bond
Publikováno v:
Behavioural Pharmacology. 22:385-389
The acute and chronic effects of certain drugs can often be opposite. For example, in congestive heart failure acute administration of β-adrenoceptor agonists results in a beneficial improvement in symptoms of the disease, but their chronic use incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f8a13ec66a6296beb49013361a2e7b
https://doi.org/10.1097/fbp.0b013e328348ec6f
https://doi.org/10.1097/fbp.0b013e328348ec6f
Autor:
Terry P. Kenakin, David W. Gray, Jim Coote, Alan Wise, Heather Giles, Cynthia L. Burns-Kurtis, Sara Pritchard, Noel Lloyd Staton, Jason D. Brown, Richard J. Wilson, Valerie Morrison, Susan Roomans, Sharron A. Rhodes, Kerri Ann Cartwright, Gerard Martin Paul Giblin, Jannatara Chowdhury, Vanessa J. Shield
Publikováno v:
British Journal of Pharmacology. 148:326-339
1. N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl}benzene sulphonamide (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptors with additional human TP receptor affinity. 2. At r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf558d34ada4757fe816bf62db7fd827
https://doi.org/10.1038/sj.bjp.0706726
https://doi.org/10.1038/sj.bjp.0706726
Autor:
Heather Giles, Richard J. Wilson
Publikováno v:
British Journal of Pharmacology. 144:405-415
1 Prostaglandin E2 produced endothelium-independent relaxation of phenylephrine- and 5-HT-contracted piglet saphenous vein (PSV; pEC50=8.6±0.2; n=6). 2 The prostanoid EP4 receptor antagonist GW627368X (30–300 nM) produced parallel rightward displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c7ba7a88bba0027de1e3ff7b2154b08
https://doi.org/10.1038/sj.bjp.0706088
https://doi.org/10.1038/sj.bjp.0706088
Autor:
David W. Gray, Richard L. Wood, Heather Giles, Vanessa J. Shield, L. Staton Noel, Richard J. Wilson, Sharron A. Rhodes
Publikováno v:
European Journal of Pharmacology. 501:49-58
Prostanoid EP(2) and EP(4) receptor-mediated responses are difficult to distinguish pharmacologically because of the lack of potent, selective antagonists. We describe systematic agonist fingerprints for recombinant human prostanoid EP(2) and EP(4) r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6539d35d67798df8247a5bf5befb69
https://doi.org/10.1016/j.ejphar.2004.08.025
https://doi.org/10.1016/j.ejphar.2004.08.025
Autor:
Richard A. Bond, Donald L Cuba, Noornabi Dudekula, Kenda L. J. Evans, Brian J. Knoll, Heather Giles, Felix R. Shardonofsky, Zsuzsanna Callaerts-Vegh, Patrick Callaerts
Publikováno v:
Proceedings of the National Academy of Sciences. 101:4948-4953
The clinical effects of treatment withn β-adrenoceptor (β-AR) agonists and antagonists in heart failure vary with duration of therapy, as do the effects of β-AR agonists in asthma. Therefore, we hypothesized that chronic effects of “β-blockers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f0d7ad8810926dfe1609ed2dfa5372
https://doi.org/10.1073/pnas.0400452101
https://doi.org/10.1073/pnas.0400452101
Autor:
Carol Bronze, Dolores Conroy, Michele Acton, Katherine Cowan, Heather Giles, Mark Fenton, Michael Bowen, Richard Wormald, Fiona J. Rowe, Karen Bonstein, Anita Lightstone, Heather Waterman, Catey Bunce, Kathy Evans, Antra Zekite, Iris Gordon, Louise Halfhide, Robert Harper, Marcela Votruba, Richard Cable
Publikováno v:
BMJ Open
Objectives: The Sight Loss and Vision Priority Setting Partnership aimed to identify research priorities relating to sight loss and vision through consultation with patients, carers and clinicians. These priorities can be used to inform funding bodie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bcc9d1f2baefab02f2f3ae09ae8879e
http://europepmc.org/articles/PMC4120376
http://europepmc.org/articles/PMC4120376
Publikováno v:
British Journal of Pharmacology. 126:810-818
The effect of interleukin-8 (IL-8) and growth-related oncogene alpha (GROalpha) on [35S]-guanosine 5'-O-(3-thiotriphosphate) ([35S]GTPgammaS) binding, forskolin-stimulated cyclic AMP accumulation and cytosolic calcium concentration were determined in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::941b674d46bd4047087676706b03ac34
https://doi.org/10.1038/sj.bjp.0702329
https://doi.org/10.1038/sj.bjp.0702329
Publikováno v:
Biochemical Pharmacology. 56:1167-1174
The activation of G-proteins by melatonin mt1 receptors was studied by measuring [35S]-guanosine-5'-(3-thiotriphosphate) ([35S]-GTPgammaS) binding to membranes prepared from Chinese hamster ovary (CHO) cells stably expressing human mt1 receptors. Mel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65d2532211251faecccf88f9ddda9fc0
https://doi.org/10.1016/s0006-2952(98)00254-8
https://doi.org/10.1016/s0006-2952(98)00254-8
Autor:
A C Honey, S Moncada, D.J. Prentice, S J MacLennan, V J Barrett, Graeme R. Martin, Alan D. Robertson, Buckingham J, Heather Giles
Publikováno v:
British Journal of Pharmacology. 121:157-164
311C90 (zolmitriptan zomig: (S)-4[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone) is a novel 5-HT1B/1D receptor agonist with proven efficacy in the acute treatment of migraine. Here, we describe the receptor specificity of the drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caaff64326b93dd1a63a66afd935224c
https://doi.org/10.1038/sj.bjp.0701041
https://doi.org/10.1038/sj.bjp.0701041