Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Heathcliff Dorado Garcia"'
Autor:
Maria E. Stefanova, Elizabeth Ing-Simmons, Stefan Stefanov, Ilya Flyamer, Heathcliff Dorado Garcia, Robert Schöpflin, Anton G. Henssen, Juan M. Vaquerizas, Stefan Mundlos
Publikováno v:
Cells, Vol 12, Iss 15, p 2001 (2023)
In this study, we delve into the impact of genotoxic anticancer drug treatment on the chromatin structure of human cells, with a particular focus on the effects of doxorubicin. Using Hi-C, ChIP-seq, and RNA-seq, we explore the changes in chromatin ar
Externí odkaz:
https://doaj.org/article/edab11f3c9e34c75851868cad695b089
Autor:
Konstantin Helmsauer, Maria E. Valieva, Salaheddine Ali, Rocío Chamorro González, Robert Schöpflin, Claudia Röefzaad, Yi Bei, Heathcliff Dorado Garcia, Elias Rodriguez-Fos, Montserrat Puiggròs, Katharina Kasack, Kerstin Haase, Csilla Keskeny, Celine Y. Chen, Luis P. Kuschel, Philipp Euskirchen, Verena Heinrich, Michael I. Robson, Carolina Rosswog, Joern Toedling, Annabell Szymansky, Falk Hertwig, Matthias Fischer, David Torrents, Angelika Eggert, Johannes H. Schulte, Stefan Mundlos, Anton G. Henssen, Richard P. Koche
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic and epigenomic data and find two classes of MYCN amplicons in neuroblastomas
Externí odkaz:
https://doaj.org/article/c5b9fcaacd9648e4831d4de98b3e2479
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, and can be subcategorized histologically and/or based on PAX-FOXO1 fusion gene status. Over the last four decades, there have been no significant improvements in clinical outc
Externí odkaz:
https://doaj.org/article/025b8e17eb43450599d80e915a9839b6
Autor:
Rocío Chamorro González, Thomas Conrad, Maja C. Stöber, Robin Xu, Mădălina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brückner, Eric van Leen, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E. Stefanova, King L. Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y. Chang, Hedwig E. Deubzer, Sascha Sauer, Angelika Eggert, Johannes H. Schulte, Roland F. Schwarz, Kerstin Haase, Richard P. Koche, Anton G. Henssen
Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here we describe single-cell extrachromosomal circular DNA and transcriptome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc99ed2c6257eafccfbc8313ccf81a41
http://edoc.mdc-berlin.de/23342/2/23342suppl.zip
http://edoc.mdc-berlin.de/23342/2/23342suppl.zip
Autor:
Yi Bei, Luca Bramé, Marieluise Kirchner, Raphaela Fritsche-Guenther, Sevrine Kunz, Animesh Bhattacharya, Julia Köppke, Jutta Proba, Nadine Wittstruck, Olga A. Sidorova, Rocío Chamorro González, Heathcliff Dorado Garcia, Lotte Brückner, Robin Xu, Mădălina Giurgiu, Elias Rodriguez-Fos, Richard Koche, Clemens Schmitt, Johannes H. Schulte, Angelika Eggert, Kerstin Haase, Jennifer Kirwan, Anja I.H. Hagemann, Philipp Mertins, Jan R. Dörr, Anton G. Henssen
SummaryAlthough DNA amplifications in cancers frequently harbor passenger genes alongside oncogenes, the functional consequence of such co-amplifications and their impact for therapy remains ill-defined. We discovered that passenger co-amplifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23cec1b64f1a5767ede4a61553464d2b
https://doi.org/10.1101/2022.09.08.506647
https://doi.org/10.1101/2022.09.08.506647
Autor:
Eric Blanc, Annika Winkler, F Hertwig, Katharina Kasack, Joern Toedling, Filippos Klironomos, Victor Bardinet, Konstantin Helmsauer, Johannes H. Schulte, Anton G. Henssen, Patrick Hundsdörfer, Theresa M Thole, Natalie Timme, Ian C. MacArthur, Richard Koche, David Torrents, Elias Rodriguez-Fos, Nina Thiessen, Claudia Röefzaad, Montserrat Puiggròs, Hedwig E. Deubzer, Jessica Theissen, Karin Schmelz, Dieter Beule, Roland F. Schwarz, Carolina Rosswog, Steffen Fuchs, Rocio Chamorro, Annette Künkele, Angelika Eggert, Heathcliff Dorado Garcia, Sascha Sauer, Martin Burkert, Annabell Szymansky, Jesper L.V. Maag, Natalia Munoz-Perez, Matthias Fischer, Yi Bei
Publikováno v:
Nat Genet
Extrachromosomal circularization of DNA is an important genomic feature in cancer. The structure, composition and genome-wide frequency of extrachromosomal circular DNA, however, have not yet been extensively profiled. Here, we combined genomic and t
Autor:
Rocio Chamorro Gonzalez, Thomas Conrad, Robin Xu, Madalina Giurgiu, Maja Cwikla, Katharina Kasack, Lotte Brückner, Eric van Leen, Elias Rodriguez-Fos, Konstantin Helmsauer, Heathcliff Dorado Garcia, Yi Bei, Karin Schmelz, Sascha Sauer, Angelika Eggert, Johannes H. Schulte, Roland F. Schwarz, Kerstin Haase, Richard P. Koche, Anton G. Henssen
Publikováno v:
Cancer Research. 82:1693-1693
Extrachromosomal DNA circularization is a common event in cancer cells and frequently serves as a vehicle for cancer oncogene amplification. Random segregation of oncogene-containing extrachromosomal circular DNA promotes rapid intercellular heteroge
Autor:
Isabelle, Roeschert, Evon, Poon, Anton G, Henssen, Heathcliff Dorado, Garcia, Marco, Gatti, Celeste, Giansanti, Yann, Jamin, Carsten P, Ade, Peter, Gallant, Christina, Schülein-Völk, Petra, Beli, Mark, Richards, Mathias, Rosenfeldt, Matthias, Altmeyer, John, Anderson, Angelika, Eggert, Matthias, Dobbelstein, Richard, Bayliss, Louis, Chesler, Gabriele, Büchel, Martin, Eilers
Publikováno v:
Nat Cancer
Amplification of MYCN is the driving oncogene in a subset of high-risk neuroblastoma. The MYCN protein and the Aurora-A kinase form a complex during S phase that stabilizes MYCN. Here we show that MYCN activates Aurora-A on chromatin, which phosphory
Autor:
Martin Eilers, Peter Gallant, Celeste Giansanti, Anton G. Henssen, Angelika Eggert, Carsten P. Ade, Marco Gatti, Yann Jamin, John Anderson, Gabriele Büchel, Matthias Altmeyer, Petra Beli, Isabelle Roeschert, Heathcliff Dorado Garcia, Evon Poon, Louis Chesler, Mathias T. Rosenfeldt, Richard Bayliss, Matthias Dobbelstein, Christina Schülein-Völk, Mark W. Richards
Publikováno v:
Nature Cancer
Amplification of MYCN is the driving oncogenic change in a subset of high-risk neuroblastomas. The MYCN protein and the Aurora-A kinase form a complex during the S phase that stabilizes MYCN. Here we show that MYCN activates Aurora-A on chromatin, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b5e5a2136a5cd0abda648c77da6b97
Autor:
Yi Bei, Christian Furth, Koshi Imami, Jana Rolff, Angelika Eggert, Johannes H. Schulte, Jennifer von Stebut, Monika Scheer, Konstantin Helmsauer, Matthias Selbach, Victor Bardinet, Michael V. Ortiz, Heathcliff Dorado Garcia, Andrej Lissat, Dennis Gürgen, Georg Seifert, Patrick Hundsoerfer, Anton G. Henssen, Kerstin Haase, Joachim G. Schulz, Antje Margret Wengner, Fabian Pusch, Marieluise Kirchner, Philipp Mertins, Glorymar Ibáñez, Birgit Lala, Natalie Timme, Ian C. MacArthur, Rocío Chamorro González, Celine Y. Chen
Pathognomonic PAX3-FOXO1 fusion oncogene expression is associated with poor outcome in rhabdomyosarcoma. Combining genome-wide CRISPR screening with cell- based functional genetic approaches, we here provide evidence that PAX3-FOXO1 induces replicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c849f80077ec09157cfcca2492437ef6
https://doi.org/10.1101/2020.12.04.411413
https://doi.org/10.1101/2020.12.04.411413