Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Heath Guay"'
Publikováno v:
Inflammatory Bowel Diseases. 29:771-782
Background Janus kinase (JAK) 1 inhibitor upadacitinib and IL-23 inhibitor risankizumab are efficacious in inflammatory bowel disease (IBD) patients who are antitumor necrosis factor (anti-TNF)-α inadequate responders (TNF-IRs). We aimed to understa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78051566047703fd32b779ef873cf3be
https://doi.org/10.1093/ibd/izac246
https://doi.org/10.1093/ibd/izac246
Autor:
Azucena Salas, Miriam Esteller, Ana P. Lacerda, Juan José Lozano, Lluís Revilla, Alba Garrido-Trigo, Núria Planell, J Butler, Daniel Aguilar, Heath Guay, Julián Panés, Justin W. Davis
Publikováno v:
Inflammatory Bowel Diseases
Background Janus kinase (JAK) inhibition shows promise for treatment of patients with moderate to severe Crohn’s disease. We aimed to provide mechanistic insights into the JAK1-selective inhibitor upadacitinib through a transcriptomics substudy on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551d2f771b058e2264c5e5bdb485a5d2
https://doi.org/10.1093/ibd/izab116
https://doi.org/10.1093/ibd/izab116
Autor:
Severine Vermeire, Heath Guay, Feng Hong, Melanie Ruzek, Julián Panés, Justin W. Davis, Naim Mahi, Tariq Ahmad, James A. Butler, Alexandra Song, Xiaohong Cao, Nizar Smaoui, Nicholas A. Kennedy, Thierry Sornasse, Jasmina Kalabic, Bram Verstockt, James Fann, Valerie Pivorunas, Azucena Salas
Publikováno v:
American Journal of Gastroenterology. 116:S375-S376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c49dd32a00b0f08cbf9b7e9120df8d27
https://doi.org/10.14309/01.ajg.0000776764.05441.56
https://doi.org/10.14309/01.ajg.0000776764.05441.56
Autor:
Melanie Ruzek, Xiaohong Cao, Alexandra Song, Valerie Pivorunas, Jean-Frederic Colombel, Nizar Smaoui, Feng Hong, Julián Panés, Justin W. Davis, Nael M. Mostafa, James A. Butler, Naim Mahi, Jasmina Kalabic, Heath Guay, Marc Ferrante, James Fann, Florian Rieder
Publikováno v:
American Journal of Gastroenterology. 116:S376-S376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5d128f051aa573751eb3d15cc12e4af
https://doi.org/10.14309/01.ajg.0000776768.33716.45
https://doi.org/10.14309/01.ajg.0000776768.33716.45
Autor:
Simeng Lin, Mark Reppell, Neil Chanchlani, Heath Guay, M W Anderson, Nicholas A. Kennedy, James R Goodhand, B M Invergo, Tariq Ahmad, J W Butler
Publikováno v:
Journal of Crohn's and Colitis. 14:S067-S068
Background Proteomic biomarkers have been linked to anti-TNF treatment failure, but previous studies have been insufficiently powered to stratify associations by drug level. The Personalised Anti-TNF Therapy in Crohn’s disease (PANTS) is a prospect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c233b661bd5725f6c534073e70d8005
https://doi.org/10.1093/ecco-jcc/jjz203.067
https://doi.org/10.1093/ecco-jcc/jjz203.067
Autor:
Heath Guay, W J Lee, Severine Vermeire, Feng Hong, J Cheng, Wen Zhou, Silvio Danese, Jesse R. Fann, Bram Verstockt, Ana P. Lacerda
Publikováno v:
Journal of Crohn's and Colitis. 14:S057-S058
Background The U-ACHIEVE trial evaluated upadacitinib (UPA), an oral JAK1 selective inhibitor, in patients with moderately to severely active ulcerative colitis (UC). Patient-reported and endoscopic outcomes improved after UPA treatment. This analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c904248d9047ad91a2924b6ce8b67455
https://doi.org/10.1093/ecco-jcc/jjz203.056
https://doi.org/10.1093/ecco-jcc/jjz203.056
Autor:
Ana P. Lacerda, Severine Vermeire, James Fann, Jie Cheng, Heath Guay, Bram Verstockt, Wan-Ju Lee, Wen Zhou, Feng Hong, Silvio Danese
Publikováno v:
Gastroenterology. 158:S-1197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65b043e8d905d40c4f79b9b213a851bd
https://doi.org/10.1016/s0016-5085(20)33659-3
https://doi.org/10.1016/s0016-5085(20)33659-3
Autor:
Bram Verstockt, Wan-Ju Lee, Ana P. Lacerda, Silvio Danese, Heath Guay, Fabio Cataldi, Feng Hong, Vermeire Severine
Publikováno v:
American Journal of Gastroenterology. 114:S471-S471
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6de15547debd31170a6f687d5bfe7442
https://doi.org/10.14309/01.ajg.0000592804.37087.94
https://doi.org/10.14309/01.ajg.0000592804.37087.94
Autor:
Subrata Ghosh, Silvio Danese, Edward V. Loftus, Heath Guay, Edouard Louis, W J Lee, F Cataldi
Publikováno v:
Journal of Crohn's and Colitis. 13:S226-S226
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61b32c97ee88f2f1dc05d5a898e73fd2
https://doi.org/10.1093/ecco-jcc/jjy222.382
https://doi.org/10.1093/ecco-jcc/jjy222.382
Autor:
Quintus G. Medley, Joe Craft, Heath Guay, Mayra Senices, Deborah Herber, Sarah A. Bertino, Sean Keegan, Tatyana A. Duzanski, Andrew L. Rankin, Nancy Stedman, Mark Ryan, Deborah Young, Laird Bloom, Kyri Dunussi-Joannopoulos, Yijun Carrier, Cheryl Nickerson-Nutter, Mary Collins
Publikováno v:
The Journal of Immunology. 188:1656-1667
MRL/MpJ-Faslpr/lpr/J (MRLlpr) mice develop lupus-like disease manifestations in an IL-21–dependent manner. IL-21 is a pleiotropic cytokine that can influence the activation, differentiation, and expansion of B and T cell effector subsets. Notably,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc891d5ac5598c935fe31180e731710d
https://doi.org/10.4049/jimmunol.1003871
https://doi.org/10.4049/jimmunol.1003871