Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Heath E. O'Brien"'
Autor:
Naomi Lyons, Isabel Softley, Andrew Balfour, Carolyn Williamson, Heath E. O’Brien, Amol C. Shetty, Vincent M. Bruno, Stephanie Diezmann
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 1075-1089 (2020)
The two leading yeast pathogens of humans, Candida albicans and Cryptococcus neoformans, cause systemic infections in >1.4 million patients worldwide with mortality rates approaching 75%. It is thus imperative to study fungal virulence mechanisms, ef
Externí odkaz:
https://doaj.org/article/6c9ef0c27e6f47d2a653b645f52962e0
Autor:
Leenah Alaalm, Julia L. Crunden, Mark Butcher, Ulrike Obst, Ryann Whealy, Carolyn E. Williamson, Heath E. O’Brien, Christiane Schaffitzel, Gordon Ramage, James Spencer, Stephanie Diezmann
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
The highly conserved, ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. In human pathogenic fungi, which kill more than 1.6 million patients each year worldwide, Hsp90 governs cellula
Externí odkaz:
https://doaj.org/article/ca17f57cc0c64ecf8c292a3a3f97e118
Autor:
Heath E. O’Brien, Eilis Hannon, Matthew J. Hill, Carolina C. Toste, Matthew J. Robertson, Joanne E. Morgan, Gemma McLaughlin, Cathryn M. Lewis, Leonard C. Schalkwyk, Lynsey S. Hall, Antonio F. Pardiñas, Michael J. Owen, Michael C. O’Donovan, Jonathan Mill, Nicholas J. Bray
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Genetic influences on gene expression in the human fetal brain plausibly impact upon a variety of postnatal brain-related traits, including susceptibility to neuropsychiatric disorders. However, to date, there have been no studies
Externí odkaz:
https://doaj.org/article/451231d2d0294c8c87bcc47a19e30cea
Autor:
Carolyn E. Williamson, Naomi Lyons, Amol C. Shetty, Isabel Softley, Andrew Balfour, Heath E. O’Brien, Stephanie Diezmann, Vincent M. Bruno
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 1075-1089 (2020)
Lyons, N, Softley, I, Balfour, A, Williamson, C, O'Brien, H E, Shetty, A C, Bruno, V M & Diezmann, S 2020, ' Tobacco Hornworm (Manduca sexta) caterpillars as a novel host model for the study of fungal virulence and drug efficacy ', Virulence, vol. 11, no. 1, pp. 1075-1089 . https://doi.org/10.1080/21505594.2020.1806665
Virulence
article-version (VoR) Version of Record
Lyons, N, Softley, I, Balfour, A, Williamson, C, O'Brien, H E, Shetty, A C, Bruno, V M & Diezmann, S 2020, ' Tobacco Hornworm (Manduca sexta) caterpillars as a novel host model for the study of fungal virulence and drug efficacy ', Virulence, vol. 11, no. 1, pp. 1075-1089 . https://doi.org/10.1080/21505594.2020.1806665
Virulence
article-version (VoR) Version of Record
The two leading yeast pathogens of humans, Candida albicans and Cryptococcus neoformans, cause systemic infections in >1.4 million patients worldwide with mortality rates approaching 75%. It is thus imperative to study fungal virulence mechanisms, ef
Autor:
Michael Conlon O'Donovan, Michael John Owen, James T.R. Walters, Nicholas John Bray, Oliver Pain, Heath E. O’Brien, Lynsey S. Hall, Richard Anney
Publikováno v:
Molecular psychiatry
The majority of common risk alleles identified for neuropsychiatric disorders reside in noncoding regions of the genome and are therefore likely to impact gene regulation. However, the genes that are primarily affected and the nature and developmenta
Autor:
Ryann Whealy, Julia L. Crunden, Christiane Schaffitzel, Carolyn E. Williamson, Ulrike Obst, Leenah Alaalm, Mark C. Butcher, Heath E. O’Brien, James Spencer, Stephanie Diezmann, Gordon Ramage
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Alaalm, L, Crunden, J L, Butcher, M, Obst, U, Whealy, R, Williamson, C, O'Brien, H, Berger-Schaffitzel, C H, Ramage, G, Spencer, J & Diezmann, S 2021, ' Identification and Phenotypic Characterization of Hsp90 Phosphorylation Sites That Modulate Virulence Traits in the Major Human Fungal Pathogen Candida albicans ', Frontiers in Cellular and Infection Microbiology, vol. 11, 637836 . https://doi.org/10.3389/fcimb.2021.637836
Alaalm, L, Crunden, J L, Butcher, M, Obst, U, Whealy, R, Williamson, C, O'Brien, H, Berger-Schaffitzel, C H, Ramage, G, Spencer, J & Diezmann, S 2021, ' Identification and Phenotypic Characterization of Hsp90 Phosphorylation Sites That Modulate Virulence Traits in the Major Human Fungal Pathogen Candida albicans ', Frontiers in Cellular and Infection Microbiology, vol. 11, 637836 . https://doi.org/10.3389/fcimb.2021.637836
The highly conserved, ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. In human pathogenic fungi, which kill more than 1.6 million patients each year worldwide, Hsp90 governs cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda6025d9c09fdff3737256c6e8c53f0
https://eprints.gla.ac.uk/242766/1/242766.pdf
https://eprints.gla.ac.uk/242766/1/242766.pdf
Autor:
Leenah, Alaalm, Julia L, Crunden, Mark, Butcher, Ulrike, Obst, Ryann, Whealy, Carolyn E, Williamson, Heath E, O'Brien, Christiane, Schaffitzel, Gordon, Ramage, James, Spencer, Stephanie, Diezmann
Publikováno v:
Frontiers in Cellular and Infection Microbiology
The highly conserved, ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. In human pathogenic fungi, which kill more than 1.6 million patients each year worldwide, Hsp90 governs cellula
Autor:
Mark C. Butcher, Ryann Whealy, Stephanie Diezmann, Carolyn E. Williamson, Ulrike Obst, Leenah Alaalm, Gordon Ramage, Heath E. O’Brien, Julia L. Crunden, Christiane Schaffitzel
The ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. Hsp90 also regulates cellular morphogenesis, drug resistance, and virulence in human pathogenic fungi, which kill more than 1.6 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76a1990477d37538cbb425d3fd1706fb
https://doi.org/10.1101/2020.09.23.309831
https://doi.org/10.1101/2020.09.23.309831
Autor:
Amol C. Shetty, Isabel Softley, Stephanie Diezmann, Carolyn E. Williamson, Vincent M. Bruno, Heath E. O’Brien, Andrew Balfour, Naomi Lyons
The two leading yeast pathogens of humans, Candida albicans and Cryptococcus neoformans, cause systemic infections in >1.4 million patients world-wide with mortality rates approaching 75%. It is thus imperative to study fungal virulence mechanisms, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::967c68c5ff01adc947d5491796ec9e78
https://doi.org/10.1101/693226
https://doi.org/10.1101/693226
Autor:
Eilis Hannon, Jonathan Mill, Michael Conlon O'Donovan, William Davies, Richard Anney, Aaron R. Jeffries, Matthew Hill, Heath E. O’Brien, Nicholas John Bray
Widespread structural, chemical and molecular differences have been reported between the male and female human brain. Although several neurodevelopmental disorders are more commonly diagnosed in males, little is known regarding sex differences in ear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483b819e3d33a86e85155eb5436536c0
https://doi.org/10.1101/483636
https://doi.org/10.1101/483636