Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Heath E. Johnson"'
Publikováno v:
PLoS Genetics, Vol 18, Iss 1, p e1010002 (2022)
A critical step in animal development is the specification of primordial germ cells (PGCs), the precursors of the germline. Two seemingly mutually exclusive mechanisms are implemented across the animal kingdom: epigenesis and preformation. In epigene
Externí odkaz:
https://doaj.org/article/e63ae955147f4e3c986e8705df4d3d18
Autor:
Emily K. Ho, Harrison R. Oatman, Sarah E. McFann, Liu Yang, Heath E. Johnson, Stanislav Y. Shvartsman, Jared E. Toettcher
Positional information in developing tissues often takes the form of stripes of gene expression that mark the boundaries of a particular cell type or morphogenetic process. How stripes form is still in many cases poorly understood. Here we use optoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9527b17962c611e710641234cb83ce8f
https://doi.org/10.1101/2023.03.09.531972
https://doi.org/10.1101/2023.03.09.531972
Autor:
Heath E. Johnson
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630075
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd889edd2c82c995d295745e2178f637
https://doi.org/10.1007/978-1-0716-3008-2_14
https://doi.org/10.1007/978-1-0716-3008-2_14
Autor:
Jared E. Toettcher, Heath E. Johnson
Publikováno v:
Current Opinion in Biotechnology. 52:42-48
In developmental biology, localization is everything. The same stimulus –a cell signaling event or expression of a gene – can have dramatically different effects depending on the time, spatial position, and cell types in which it is applied. Yet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65131ba7eba47791508830c854c09056
https://doi.org/10.1016/j.copbio.2018.02.003
https://doi.org/10.1016/j.copbio.2018.02.003
Publikováno v:
Current biology : CB. 30(17)
Summary Animal embryos are patterned by a handful of highly conserved inductive signals. Yet, in most cases, it is unknown which pattern features (i.e., spatial gradients or temporal dynamics) are required to support normal development. An ideal expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796eb1fdc86c79ce300d2b525c93f17c
https://pubmed.ncbi.nlm.nih.gov/32898501
https://pubmed.ncbi.nlm.nih.gov/32898501
Animal embryos are partitioned into spatial domains by complex patterns of signaling and gene expression, yet it is still largely unknown what features of a developmental signal are essential. Part of the challenge arises because it has been impossib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac93f09eb970b472b71332dd42987bfe
Autor:
Jason M. Haugh, Heath E. Johnson
Publikováno v:
Biophysical Journal. 111:1827-1830
Filopodia are thin, fingerlike structures that contain bundled actin filaments and project from the cell periphery. These structures are dogmatically endowed with the ability to sense cues in the microenvironment, implying that filopodia foster local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65f03cc09dc913ab49ab174b0620bff
https://doi.org/10.1016/j.bpj.2016.09.022
https://doi.org/10.1016/j.bpj.2016.09.022
Autor:
Heath E. Johnson, Maria S. Shutova, Jason M. Haugh, James E. Bear, Tatyana Svitkina, Sreeja B. Asokan, John D. Sondek
SUMMARYLysophophatidic acid (LPA), a biologically active phospholipid that is ubiquitously present in tissues and organs, provokes cellular responses such as proliferation, apoptosis, differentiation and migration via activation of G-protein coupled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c714c2253e0fb0d1ffc9b86c5d4be14
https://doi.org/10.1101/355610
https://doi.org/10.1101/355610
Autor:
James E. Bear, Heath E. Johnson, Sreeja B. Asokan, Samantha J. King, Jason M. Haugh, Elizabeth M. Haynes
Publikováno v:
The Journal of Cell Biology
The primary activity of GMFβ in vivo is actin branch disassembly (and not inhibition of Arp2/3 activation), and this activity plays an important role in lamellipodial dynamics and directional migration toward ECM cues.
The lamellipodium is an i
The lamellipodium is an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2ef55ce98e8915affe126e97168f33
http://europepmc.org/articles/PMC4477851
http://europepmc.org/articles/PMC4477851
Autor:
Sreeja B. Asokan, Samantha J. King, Jeremy D. Rotty, Jason M. Haugh, Heath E. Johnson, James E. Bear
Publikováno v:
The Journal of Cell Biology
During cell migration, F-actin bundles/filopodia serve as templates for formation and orientation of lamellipodia and prime their stabilization by adhesion-based PI3K signaling.
Mesenchymal cells such as fibroblasts are weakly polarized and reor
Mesenchymal cells such as fibroblasts are weakly polarized and reor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f1504d76a44feea5af07b36540f560
http://europepmc.org/articles/PMC4332254
http://europepmc.org/articles/PMC4332254