Výsledky vyhledávání - "Heath E O'Brien"

Akademický článek

Genomic and Gene-Expression Comparisons among Phage-Resistant Type-IV Pilus Mutants of Pseudomonas syringae pathovar phaseolicola.

Autor: Mark Sistrom, Derek Park, Heath E O'Brien, Zheng Wang, David S Guttman, Jeffrey P Townsend, Paul E Turner

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144514 (2015)

Pseudomonas syringae pv. phaseolicola (Pph) is a significant bacterial pathogen of agricultural crops, and phage Φ6 and other members of the dsRNA virus family Cystoviridae undergo lytic (virulent) infection of Pph, using the type IV pilus as the in

Externí odkaz: https://doaj.org/article/5d06bfc7a4d44e6daa6eac9e7d474977

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Akademický článek

Use of low-coverage, large-insert, short-read data for rapid and accurate generation of enhanced-quality draft Pseudomonas genome sequences.

Autor: Heath E O'Brien, Yunchen Gong, Pauline Fung, Pauline W Wang, David S Guttman

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27199 (2011)

Next-generation genomic technology has both greatly accelerated the pace of genome research as well as increased our reliance on draft genome sequences. While groups such as the Genomics Standards Consortium have made strong efforts to promote genome

Externí odkaz: https://doaj.org/article/ba3c07cf52464e579330fba08fbc600d

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Tobacco Hornworm (Manduca sexta) caterpillars as a novel host model for the study of fungal virulence and drug efficacy

Autor: Carolyn E. Williamson, Naomi Lyons, Amol C. Shetty, Isabel Softley, Andrew Balfour, Heath E. O’Brien, Stephanie Diezmann, Vincent M. Bruno

Publikováno v: Virulence, Vol 11, Iss 1, Pp 1075-1089 (2020)
Lyons, N, Softley, I, Balfour, A, Williamson, C, O'Brien, H E, Shetty, A C, Bruno, V M & Diezmann, S 2020, ' Tobacco Hornworm (Manduca sexta) caterpillars as a novel host model for the study of fungal virulence and drug efficacy ', Virulence, vol. 11, no. 1, pp. 1075-1089 . https://doi.org/10.1080/21505594.2020.1806665
Virulence
article-version (VoR) Version of Record

The two leading yeast pathogens of humans, Candida albicans and Cryptococcus neoformans, cause systemic infections in >1.4 million patients worldwide with mortality rates approaching 75%. It is thus imperative to study fungal virulence mechanisms, ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f45043fb04020debef373937446f79d
https://doi.org/10.1080/21505594.2020.1806665

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Cis-effects on gene expression in the human prenatal brain associated with genetic risk for neuropsychiatric disorders

Autor: Michael Conlon O'Donovan, Michael John Owen, James T.R. Walters, Nicholas John Bray, Oliver Pain, Heath E. O’Brien, Lynsey S. Hall, Richard Anney

Publikováno v: Molecular psychiatry

The majority of common risk alleles identified for neuropsychiatric disorders reside in noncoding regions of the genome and are therefore likely to impact gene regulation. However, the genes that are primarily affected and the nature and developmenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baac4a76bde90af9e54b75ce1851ce9a
http://europepmc.org/articles/PMC7611670

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Identification and phenotypic characterization of Hsp90 phosphorylation sites that modulate virulence traits in the major human fungal pathogen Candida albicans

Autor: Ryann Whealy, Julia L. Crunden, Christiane Schaffitzel, Carolyn E. Williamson, Ulrike Obst, Leenah Alaalm, Mark C. Butcher, Heath E. O’Brien, James Spencer, Stephanie Diezmann, Gordon Ramage

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Alaalm, L, Crunden, J L, Butcher, M, Obst, U, Whealy, R, Williamson, C, O'Brien, H, Berger-Schaffitzel, C H, Ramage, G, Spencer, J & Diezmann, S 2021, ' Identification and Phenotypic Characterization of Hsp90 Phosphorylation Sites That Modulate Virulence Traits in the Major Human Fungal Pathogen Candida albicans ', Frontiers in Cellular and Infection Microbiology, vol. 11, 637836 . https://doi.org/10.3389/fcimb.2021.637836

The highly conserved, ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. In human pathogenic fungi, which kill more than 1.6 million patients each year worldwide, Hsp90 governs cellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda6025d9c09fdff3737256c6e8c53f0
https://eprints.gla.ac.uk/242766/1/242766.pdf

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Identification and Phenotypic Characterization of Hsp90 Phosphorylation Sites That Modulate Virulence Traits in the Major Human Fungal Pathogen

Autor: Leenah, Alaalm, Julia L, Crunden, Mark, Butcher, Ulrike, Obst, Ryann, Whealy, Carolyn E, Williamson, Heath E, O'Brien, Christiane, Schaffitzel, Gordon, Ramage, James, Spencer, Stephanie, Diezmann

Publikováno v: Frontiers in Cellular and Infection Microbiology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e5d2280cc586aaf8e6a8d8b15f159b8
https://pubmed.ncbi.nlm.nih.gov/34513723

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A novel Hsp90 phospho-switch modulates virulence in the major human fungal pathogenCandida albicans

Autor: Mark C. Butcher, Ryann Whealy, Stephanie Diezmann, Carolyn E. Williamson, Ulrike Obst, Leenah Alaalm, Gordon Ramage, Heath E. O’Brien, Julia L. Crunden, Christiane Schaffitzel

The ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. Hsp90 also regulates cellular morphogenesis, drug resistance, and virulence in human pathogenic fungi, which kill more than 1.6 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76a1990477d37538cbb425d3fd1706fb
https://doi.org/10.1101/2020.09.23.309831

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Tobacco Hornworm (Manduca sexta) caterpillars as a novel host model for the study of fungal virulence and drug efficacy

Autor: Amol C. Shetty, Isabel Softley, Stephanie Diezmann, Carolyn E. Williamson, Vincent M. Bruno, Heath E. O’Brien, Andrew Balfour, Naomi Lyons

The two leading yeast pathogens of humans, Candida albicans and Cryptococcus neoformans, cause systemic infections in >1.4 million patients world-wide with mortality rates approaching 75%. It is thus imperative to study fungal virulence mechanisms, e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::967c68c5ff01adc947d5491796ec9e78
https://doi.org/10.1101/693226

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Sex differences in gene expression in the human fetal brain

Autor: Eilis Hannon, Jonathan Mill, Michael Conlon O'Donovan, William Davies, Richard Anney, Aaron R. Jeffries, Matthew Hill, Heath E. O’Brien, Nicholas John Bray

Widespread structural, chemical and molecular differences have been reported between the male and female human brain. Although several neurodevelopmental disorders are more commonly diagnosed in males, little is known regarding sex differences in ear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483b819e3d33a86e85155eb5436536c0
https://doi.org/10.1101/483636

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Novel Insight into the Aetiology of Autism Spectrum Disorder Gained by Integrating Expression Data with Genome-wide Association Statistics

Autor: Michael Conlon O'Donovan, Michael J. Owen, Lynsey S. Hall, Nicholas John Bray, Richard Anney, Heath E. O’Brien, Peter Holmans, Andrew Pocklington, Antonio F. Pardiñas, Oliver Pain

Publikováno v: Biological Psychiatry

BackgroundA recent genome-wide association study (GWAS) of autism spectrum disorders (ASD) (Ncases=18,381, Ncontrols=27,969) has provided novel opportunities for investigating the aetiology of ASD. Here, we integrate the ASD GWAS summary statistics w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b8495f22aff5a5d42f085b8d99a529
https://doi.org/10.1101/480624

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