Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Heath E Klock"'
Autor:
Qingping Xu, Gilles P van Wezel, Hsiu-Ju Chiu, Lukasz Jaroszewski, Heath E Klock, Mark W Knuth, Mitchell D Miller, Scott A Lesley, Adam Godzik, Marc-André Elsliger, Ashley M Deacon, Ian A Wilson
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41359 (2012)
Actinomycetes are important bacterial sources of antibiotics and other secondary metabolites. Many antibiotic gene clusters are controlled by pathway-specific activators that act in response to growth conditions. Here we present the crystal structure
Externí odkaz:
https://doaj.org/article/22bb6da506f943bd8bc2e65b7fefc3c6
Autor:
Abhinav Kumar, Sabine Möcklinghoff, Fumiaki Yumoto, Lukasz Jaroszewski, Carol L Farr, Anna Grzechnik, Phuong Nguyen, Christian X Weichenberger, Hsiu-Ju Chiu, Heath E Klock, Marc-André Elsliger, Ashley M Deacon, Adam Godzik, Scott A Lesley, Bruce R Conklin, Robert J Fletterick, Ian A Wilson
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e43761 (2012)
The human nuclear factor related to kappa-B-binding protein (NFRKB) is a 1299-residue protein that is a component of the metazoan INO80 complex involved in chromatin remodeling, transcription regulation, DNA replication and DNA repair. Although full
Externí odkaz:
https://doaj.org/article/ea0eeba6acc149beb88802036b6c31a7
Autor:
Debanu Das, Mireille Hervé, Julie Feuerhelm, Carol L Farr, Hsiu-Ju Chiu, Marc-André Elsliger, Mark W Knuth, Heath E Klock, Mitchell D Miller, Adam Godzik, Scott A Lesley, Ashley M Deacon, Dominique Mengin-Lecreulx, Ian A Wilson
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17624 (2011)
Bacterial cell walls contain peptidoglycan, an essential polymer made by enzymes in the Mur pathway. These proteins are specific to bacteria, which make them targets for drug discovery. MurC, MurD, MurE and MurF catalyze the synthesis of the peptidog
Externí odkaz:
https://doaj.org/article/3579f29d15a044a7b200ed31f29f9110
Autor:
Qingping Xu, Neil D Rawlings, Hsiu-Ju Chiu, Lukasz Jaroszewski, Heath E Klock, Mark W Knuth, Mitchell D Miller, Marc-Andre Elsliger, Ashley M Deacon, Adam Godzik, Scott A Lesley, Ian A Wilson
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22013 (2011)
NlpC/P60 superfamily papain-like enzymes play important roles in all kingdoms of life. Two members of this superfamily, LRAT-like and YaeF/YiiX-like families, were predicted to contain a catalytic domain that is circularly permuted such that the cata
Externí odkaz:
https://doaj.org/article/8d7470ad34784f1d8219b7ac8a34f5ed
Autor:
Qingping Xu, Neil D Rawlings, Carol L Farr, Hsiu-Ju Chiu, Joanna C Grant, Lukasz Jaroszewski, Heath E Klock, Mark W Knuth, Mitchell D Miller, Dana Weekes, Marc-André Elsliger, Ashley M Deacon, Adam Godzik, Scott A Lesley, Ian A Wilson
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21875 (2011)
Imelysin-like proteins define a superfamily of bacterial proteins that are likely involved in iron uptake. Members of this superfamily were previously thought to be peptidases and were included in the MEROPS family M75. We determined the first crysta
Externí odkaz:
https://doaj.org/article/97645952e15f40f58e65882fee83ec22
Autor:
Catharine L. Eastman, Gregory B. Chisholm, Julie Vance, Kai Zinn, Dirk Siepe, Heath E. Klock, K. Christopher Garcia, Scott Martin Glaser, Scott A. Lesley, Sarah Cox, Woj M. Wojtowicz, Jost Vielmetter, Ricardo A. Fernandes, Paul Anderson, Melisa L. Bragstad, Annie W. Lam, Jessica J. Miller, Sarah Rue
Publikováno v:
Cell
Summary Cell-surface protein-protein interactions (PPIs) mediate cell-cell communication, recognition, and responses. We executed an interactome screen of 564 human cell-surface and secreted proteins, most of which are immunoglobulin superfamily (IgS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb88b5e0a3459806af75a948cee0f7a
https://pubmed.ncbi.nlm.nih.gov/32822567
https://pubmed.ncbi.nlm.nih.gov/32822567
Autor:
Weijia Ou, Susan E. Cellitti, Bernhard H. Geierstanger, Paula Patterson, Xing Wang, Heath E. Klock, Edward Nigoghossian, Ansgar Brock, Hung Tong, Dylan Daniel, Jan Grünewald, Badry Bursulaya, William Mallet, David H. Jones, Tetsuo Uno, Daniel McMullan, Hsien-Po Chiu, Julie Vance, Huanfang Zhou, Scott A. Lesley
Publikováno v:
Bioconjugate Chemistry. 26:2554-2562
Post-translational modification catalyzed by phosphopantetheinyl transferases (PPTases) has previously been used to site-specifically label proteins with structurally diverse molecules. PPTase catalysis results in covalent modification of a serine re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7286bacea55f1489eb11261e6f30abd6
https://doi.org/10.1021/acs.bioconjchem.5b00558
https://doi.org/10.1021/acs.bioconjchem.5b00558
Autor:
Jonathan Yen, Vionnie W. C. Yu, Ning Guo, Susan C. Stevenson, Yi Liu, William R. Tschantz, Yi Yang, Craig Mickanin, Michael Fiorino, Scott Clarkson, Lisa Quinn, Carsten Russ, Cameron Lee, Steven Paula, Heath E. Klock
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
CRISPR/Cas9 mediated gene editing of patient-derived hematopoietic stem and progenitor cells (HSPCs) ex vivo followed by autologous transplantation of the edited HSPCs back to the patient can provide a potential cure for monogenic blood disorders suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56abc87475d1a0c7b05bd1383e1f91a2
https://pubmed.ncbi.nlm.nih.gov/30389991
https://pubmed.ncbi.nlm.nih.gov/30389991
Autor:
Loren Miraglia, S. Whitney Barnes, Jennifer Snead, Carsten Russ, Peter McNamara, John Lamb, Albert E. Parker, Chris Trussell, J. Scott Lee, Orzala Sharif, Pamela Y. Ting, John R. Walker, Michael P. Cooke, Anthony E. Boitano, Scott Clarkson, Fabio Luna, Heath E. Klock, Julie Vance, Mu-Yun Gao, Christian Schmedt, Glenn C. Federe
Publikováno v:
Nature methods. 15(11)
CRISPR–Cas9 screening allows genome-wide interrogation of gene function. Currently, to achieve the high and uniform Cas9 expression desirable for screening, one needs to engineer stable and clonal Cas9-expressing cells—an approach that is not app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d6ea3f1ecc35af01d19e315b272f72
https://pubmed.ncbi.nlm.nih.gov/30297964
https://pubmed.ncbi.nlm.nih.gov/30297964
Autor:
Jan Grünewald, Weijia Ou, Huanfang Zhou, Tetsuo Uno, Xing Wang, Heath E. Klock, Eric C. Peters, Jessica Read, Ansgar Brock, Julie Vance, Jin Yunho, Yongqin Wan, Bernhard H. Geierstanger
Publikováno v:
Bioconjugate chemistry. 28(7)
Phosphopantetheine transferases (PPTases) can be used to efficiently prepare site-specific antibody-drug conjugates (ADCs) by enzymatically coupling coenzyme A (CoA)-linker payloads to 11-12 amino acid peptide substrates inserted into antibodies. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63bd99ba14848ee5878640e2a238e6d3
https://pubmed.ncbi.nlm.nih.gov/28590752
https://pubmed.ncbi.nlm.nih.gov/28590752