Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Heath C. Thomas"'
Autor:
Mark F. Cesta, Vivian S. Chen, Gargi Srivastava, Rajesh Ugalmugle, Kristen Hobbie, Heath C. Thomas, Thomas J Steinbach, Caroll A. Co, Emily Singletary, Keith R. Shockley, Debra A Tokarz, Avinash Lokhande, Torrie A. Crabbs
Publikováno v:
Toxicol Pathol
Rodent progressive cardiomyopathy (PCM) encompasses a constellation of microscopic findings commonly seen as a spontaneous background change in rat and mouse hearts. Primary histologic features of PCM include varying degrees of cardiomyocyte degenera
Autor:
Vinicius Carreira, Carie L Kimbrough, Abraham Nyska, Gail Pearse, Noel Dybdal, James R. Hailey, Niraj Tripathi, James D Fikes, Jan Klapwijk, Susan A. Elmore, Ingrid Brees, Beverly E. Maleeff, Kathleen Biddle, Brian R. Berridge, Martin Lamb, Rick Adler, Patrizia Cristofori, Bernard S. Buetow, Jean-Guy Bienvenu, Heather C. Workman, Daniel Morton, Heath C. Thomas, James R. Turk, Jerry F. Hardisty, David A Rehagen, George A. Parker
Publikováno v:
Toxicologic Pathology. 45:1055-1066
To test the diagnostic approach described in part 1 of this article, 2 exercises were completed by pathologists from multiple companies/agencies. Pathologist’s examination of whole slide image (WSI) heart sections from rats using personal diagnosti
Autor:
Martin Lamb, Vinicius Carreira, Abraham Nyska, Carie L Kimbrough, Niraj Tripathi, Susan A. Elmore, Daniel Morton, Ingrid Brees, Noel Dybdal, Bernard S. Buetow, Heath C. Thomas, Beverly E. Maleeff, Kathleen Biddle, Rick Adler, James D Fikes, Brian R. Berridge, Jan Klapwijk, David A Rehagen, James R. Hailey, Patrizia Cristofori, George A. Parker, Heather C. Workman, Jean-Guy Bienvenu, Jerry F. Hardisty, Gail Pearse, James R. Turk
Publikováno v:
Toxicologic pathology. 45(8)
Spontaneous rodent progressive cardiomyopathy (PCM) in the Sprague Dawley rat may confound identification and/or interpretation of potential test article (TA)-related cardiotoxicity. Pathologists apply diagnostic term(s) and thresholds for diagnosing
Autor:
Michael T. Lawton, Rudy J. Richardson, Calvert Louden, Robert R. Montgomery, Heath C. Thomas, Anne M. Katein, David Brott
Publikováno v:
Toxicologic Pathology. 42:672-683
Pharmacologically, vasoactive agents targeting endothelial and/or smooth muscle cells (SMC) are known to cause acute drug-induced vascular injury (DIVI) and the resulting pathology is due to endothelial cell (EC) perturbation, activation, and/or inju
Autor:
Brian R. Berridge, Malcolm York, A. Casartelli, Kimberly Roland, Rick R. Adler, Alan H. Stokes, Rhiannon C. Davies, Patrizia Cristofori, Federica Crivellente, Carie L. Kimbrough, Franck Chanut, Rick Hailey, Holly L. Jordan, Jan Klapwijk, Angela Hughes-Earle, Heath C. Thomas
Publikováno v:
Toxicologic Pathology. 41:1126-1136
Cardiovascular safety signals in nonclinical studies remain among the main reasons for drug attrition during pharmaceutical research and development. Drug-induced changes can be functional and/or associated with morphological alterations in the norma
Autor:
Kendall S. Frazier, Heath C. Thomas, Rosanna C. Mirabile, Nancy T. Chau, Roberta A. Thomas, Marshall S. Scicchitano
Publikováno v:
Toxicology and Applied Pharmacology. 262:310-320
Regulatory miRNAs play a role in vascular biology and are involved in biochemical and molecular pathways dysregulated during vascular injury. Collection and integration of functional miRNA data into these pathways can provide insight into pathogenesi
Autor:
David Mullins, Kay Tatsuoka, Marshall S. Scicchitano, Angela Hughes-Earle, Heath C. Thomas, Michal Magid-Slav, Kendall S. Frazier, Deidre A. Dalmas
Publikováno v:
Toxicology and Applied Pharmacology. 257:284-300
Drug-induced vascular injury is frequently observed in rats but the relevance and translation to humans present a hurdle for drug development. Numerous structurally diverse pharmacologic agents have been shown to induce mesenteric arterial medial nec
Autor:
Beverly E. Maleeff, Patrizia Cristofori, Rick R. Adler, Charlotte M. Keenan, Angela Hughes-Earle, Jan Klapwijk, Heath C. Thomas
Publikováno v:
Toxicologic Pathology. 38:995-998
Toxicologic pathologists are tasked with morphologic evaluation of tissues in animal toxicity studies to ascertain drug or chemical-related effects. These assessments are based on knowledge of the species and spectrum of morphologic changes that occu
Publikováno v:
Toxicologic Pathology. 38:297-302
The cynomolgus macaque is the most commonly used nonhuman primate in nonclinical toxicity testing, but the impact of the geographic source of cynomolgus macaque on differences in spontaneous pathology and response to xenobiotics has only recently bee
Autor:
Heath C. Thomas, Marshall S. Scicchitano, Kendall S. Frazier, David C. McFarland, Dana C. Pietrzak, Roberta A. Thomas
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 60:263-274
Introduction There are currently few widely accepted noninvasive detection methods for drug-induced vascular damage. Circulating endothelial progenitor cell (EPC) enumeration in humans has recently gained attention as a potential biomarker of vascula