Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Heasook Kim-Kang"'
Autor:
David Heim, Heasook Kim-Kang
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S77-S78
Autor:
S. Cyrus Khojasteh, Shuguang Ma, Edna F. Choo, Cornelis E. C. A. Hop, Qin Yue, Justin Ly, Ryan H. Takahashi, Jason Boggs, Andrew McClory, Heasook Kim-Kang, Alec Fettes, Yuzhong Deng, Yijun Yi
Publikováno v:
Xenobiotica. 47:50-65
1. The absorption, metabolism and excretion of cobimetinib, an allosteric inhibitor of MEK1/2, was characterized in mass balance studies following single oral administration of radiolabeled (14C) cobimetinib to Sprague–Dawley rats (30 mg/kg) and Be
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S39
Autor:
S. Cyrus Khojasteh, Kelly Regal, Shuguang Ma, Cornelis E. C. A. Hop, Yijun Yi, Heasook Kim-Kang, Joseph P. Lyssikatos, Qin Yue, Ryan H. Takahashi, Xingrong Liu, Nicholas C. Kallan, Michael Siu, Kevin W. Hunt
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 40:171-185
(R)-2-Amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro[imidazole-4,1'-naphthalen]-5(1H)-one (GNE-892) is an orally administered inhibitor of β-secretase 1 (β-site amyloid precursor protein cleaving enzyme 1, BACE1) that was devel
Publikováno v:
Journal of AOAC INTERNATIONAL. 94:436-445
An accurate, reliable, and reproducible analytical method using HPLC/MS/MS for the determination of tulathromycin residues in bovine liver and porcine kidney via their common hydrolytic fragment (CP-60,300) was developed and validated. Briefly, the m
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S22
Publikováno v:
Drug Metabolism and Pharmacokinetics. 32:S96
Publikováno v:
Drug Metabolism and Pharmacokinetics. 32:S77
Autor:
Cornelis E. C. A. Hop, Kevin W. Hunt, Heasook Kim-Kang, Yijun Yi, Qin Yue, Xingrong Liu, Nicholas C. Kallan, Shuguang Ma, Michael Siu, Ryan H. Takahashi, Alan Deese, S. Cyrus Khojasteh
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 42(5)
We investigated an uncommon biotransformation of pyrimidine during the metabolism of GNE-892 ((R)-2-amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro[imidazole-4,1'-naphthalen]-5(1H)-one), a β-secretase 1 inhibitor. Three novel met
Publikováno v:
Journal of Agricultural and Food Chemistry. 46:707-717
The nature and magnitude of residues in apples treated with [ 14 C]diphenylamine (DPA) was investigated following treatment and storage at reduced temperature. Additional apples were treated with a mixture of [ 14 C]DPA and deuterium-labeled DPA (D-1