Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Heart Conduction System/metabolism"'
Autor:
Vadim V. Fedorov, Jichao Zhao, Ning Li, Brian J. Hansen, Peter J. Mohler, Sándor Györke, Roshan Sharma, Galina Rozenberg, Paul M.L. Janssen, Katelynn M. Helfrich, Stanislav O. Zakharkin, Bryan A. Whitson, Halina Dobrzynski, Pei Jung Wu, Anuradha Kalyanasundaram, Suhaib H. Abudulwahed, Esthela J. Artiga, John D. Hummel, Federica Accornero, Brandon J. Biesiadecki, Nahush A. Mokadam
Publikováno v:
Li, N, Kalyanasundaram, A, Hansen, B J, Artiga, E J, Sharma, R, Abudulwahed, S H, Helfrich, K M, Rozenberg, G, Wu, P-J, Zakharkin, S, Gyorke, S, Janssen, P, Whitson, B A, Mokadam, N A, Biesiadecki, B J, Accornero, F, Hummel, J D, Jichao Zhao, J, Mohler, P J, Dobrzynski, H & Fedorov, V V 2020, ' Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node ', Nature Communications, vol. 11, no. 1, 512, pp. 512 . https://doi.org/10.1038/s41467-019-14039-8
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Mechanisms for human sinoatrial node (SAN) dysfunction are poorly understood and whether human SAN excitability requires voltage-gated sodium channels (Nav) remains controversial. Here, we report that neuronal (n)Nav blockade and selective nNav1.6 bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a93e9c4e29410729a773cc9c04368c
https://doi.org/10.1038/s41467-019-14039-8
https://doi.org/10.1038/s41467-019-14039-8
Autor:
Thomas Jespersen, Bolette Hartmann, Michael Christiansen, Nicolai J. Wewer Albrechtsen, Jørgen K. Kanters, Torben Hansen, Allan Linneberg, Eva W. Iepsen, Anniek F. Lubberding, Jens J. Holst, Henrik Vestergaard, Oluf Pedersen, Signe S. Torekov, Mathilde Svendstrup, Louise Hyltén-Cavallius
Publikováno v:
Hyltén-Cavallius, L, Iepsen, E W, Wewer Albrechtsen, N J, Svendstrup, M, Lubberding, A F, Hartmann, B, Jespersen, T, Linneberg, A, Christiansen, M, Vestergaard, H, Pedersen, O, Holst, J J, Kanters, J K, Hansen, T & Torekov, S S 2017, ' Patients with Long QT Syndrome Due to Impaired hERG-encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated with Reactive Hypoglycemia ', Circulation, vol. 135, no. 18, pp. 1705-1719 . https://doi.org/10.1161/CIRCULATIONAHA.116.024279
Hyltén-Cavallius, L, Iepsen, E W, Wewer Albrechtsen, N J, Svendstrup, M, Lubberding, A F, Hartmann, B, Jespersen, T, Linneberg, A, Christiansen, M, Vestergaard, H, Pedersen, O, Holst, J J, Kanters, J K, Hansen, T & Torekov, S 2017, ' Patients with Long QT Syndrome Due to Impaired hERG-encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated with Reactive Hypoglycemia ', Circulation, vol. 135, no. 18, pp. 1705-1719 . https://doi.org/10.1161/CIRCULATIONAHA.116.024279
Hyltén-Cavallius, L, Iepsen, E W, Wewer Albrechtsen, N J, Svendstrup, M, Lubberding, A F, Hartmann, B, Jespersen, T, Linneberg, A, Christiansen, M, Vestergaard, H, Pedersen, O, Holst, J J, Kanters, J K, Hansen, T & Torekov, S S 2017, ' Patients with Long-QT Syndrome Caused by Impaired hERG-Encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated with Reactive Hypoglycemia ', Circulation, vol. 135, no. 18, pp. 1705-1719 . https://doi.org/10.1161/CIRCULATIONAHA.116.024279
Hyltén-Cavallius, L, Iepsen, E W, Wewer Albrechtsen, N J, Svendstrup, M, Lubberding, A F, Hartmann, B, Jespersen, T, Linneberg, A, Christiansen, M, Vestergaard, H, Pedersen, O, Holst, J J, Kanters, J K, Hansen, T & Torekov, S 2017, ' Patients with Long QT Syndrome Due to Impaired hERG-encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated with Reactive Hypoglycemia ', Circulation, vol. 135, no. 18, pp. 1705-1719 . https://doi.org/10.1161/CIRCULATIONAHA.116.024279
Hyltén-Cavallius, L, Iepsen, E W, Wewer Albrechtsen, N J, Svendstrup, M, Lubberding, A F, Hartmann, B, Jespersen, T, Linneberg, A, Christiansen, M, Vestergaard, H, Pedersen, O, Holst, J J, Kanters, J K, Hansen, T & Torekov, S S 2017, ' Patients with Long-QT Syndrome Caused by Impaired hERG-Encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated with Reactive Hypoglycemia ', Circulation, vol. 135, no. 18, pp. 1705-1719 . https://doi.org/10.1161/CIRCULATIONAHA.116.024279
Background: Loss-of-function mutations in hERG (encoding the K v 11.1 voltage-gated potassium channel) cause long-QT syndrome type 2 (LQT2) because of prolonged cardiac repolarization. However, K v 11.1 is also present in pancreatic α and β cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa3e5dfa6db2db84dd560e5c140b9ca
https://curis.ku.dk/portal/da/publications/patients-with-long-qt-syndrome-due-to-impaired-hergencoded-kv111-potassium-channel-have-exaggerated-endocrine-pancreatic-and-incretin-function-associated-with-reactive-hypoglycemia(b3415700-4dc0-4294-a7bc-f0de156cbde2).html
https://curis.ku.dk/portal/da/publications/patients-with-long-qt-syndrome-due-to-impaired-hergencoded-kv111-potassium-channel-have-exaggerated-endocrine-pancreatic-and-incretin-function-associated-with-reactive-hypoglycemia(b3415700-4dc0-4294-a7bc-f0de156cbde2).html
